Chapter 25

Question 1

Patho of Inflammation

Answer 1

• reaction to tissue injury
• caused by release of chemical mediators
• leads to a vascular response
• fluid and WBCs migrate to injured site

Question 2

Prostaglandins

Answer 2

Chemical mediators in inflammation

-increase capillary permeability, vasodilation, and increase pain and fevers

Question 3

Cox enzyme

Answer 3

converts arachidonic acid to prostaglandins

Question 4

Cox-1

Answer 4

protects stomach lining and regulates blood platelets

Question 5

Cox-2

Answer 5

Triggers inflammation and pain

Question 6

NSAIDS

Answer 6

nonsteroidal antiinflammatory drugs

-Aspirin (Salicylates)

Question 7

Corticosteroids

Answer 7

suppress or prevent inflammation

Question 8

DMARD

Answer 8

disease modifying anti rheumatic drugs

Question 9

NSAID function

Answer 9

• inhibit biosynthesis of prostoglandins
• analgestic and antipyretic
• inhibit platelet aggregations
• mimic effects of corticosteroids

Question 10

NSAID action

Answer 10

-inhibit COX enzyme and prostaglandin synthesis

Question 11

1st generation NSAIDS

Answer 11

a. Salicylates – PROTOTYPE: aspirin

b. Proprionic acid derivatives – PROTOTYPE: ibuprofen

Question 12

Foods containing salicylates

Answer 12

prunes, raisins, licorice, spices

Question 13

Reye’s syndrome

Answer 13

When Aspirin is given to a child with a viral infection

Question 14

Propionic acid derivatives

Answer 14

ibuprofen: advil/motrin

Question 15

COX 2 inhibitor prototype

Answer 15

celecoxib

Question 16

Gold drug therapy

Answer 16

DMARD

• decreases leukocyte migration
• suppresses prostaglandin activity
• stops progression of joint degeneration

Question 17

DMARD

Answer 17

disease modifying antirheumatic drugs

Question 18

Side effects of gold drug therapy

Answer 18

-stomatitis, photosensitivity, metallic taste, sever rash, corneal gold deposits, bradycardia, hypotension,hematuria, nephrotoxicity

Question 19

Immunomodulators

Answer 19

tumor necrosis factor blockers

-used for rheumatoid arthritis

Question 20

Immunomodulator drugs

Answer 20

• end in CEPT is a biologic

- end in ab, monoclonal antibodies work with immune system

Question 21

Infliximab

Answer 21

-Remicade

Question 22

Anti gout drugs

Answer 22

colchcine
uric acid inhibitors
uricosurics

Question 23

Colchicine

Answer 23

inhibit migration of leukocytes to inflamed site

Question 24

Uric acid inhibitors

Answer 24

Allopurinol

-decrease uric acid levels

Question 25

Uricosurics

Answer 25

Probenecid

-blocks reabsorption of uric acid and increases excretion