Chapter 3 Flashcards

(38 cards)

1
Q

What is the function of an interneuron?

A

Associate sensory and motor activity within the central nervous system.

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2
Q

What is the function of a motor neuron?

A

Send signals from the brain and spinal cord to the muscles

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3
Q

What are the characteristics of a pyramidal neuron?

A

Found in the cortex, 2 sets of dendrites, a very long axon, and a pyramid shaped cell body.

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4
Q

What is the main difference between an interneuron and a motor and sensory neuron?

A

Interneurons are much more complex

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5
Q

What are the features of a Purkinje cell?

A

extremely branched dendrites, directs info from the cerebellum to the rest of the brain.

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6
Q

What are the features of a motor neuron?

A

Complex dendrites, long axons that connect to muscles. Located in the lower brainstem and spinal cord.

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7
Q

What are the features of sensory neurons and what are some examples?

A

Structurally, very simple; Bipolar neuron: found in the retina, conduct afferent info to the visual centres of the brain; Somatosensory neuron: afferent info into the spinal cord.

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8
Q

How is it that neurons talk to each other?

A

Each neuron receives thousands of excitatory and inhibitory signals every second. Neurons sum these signals and respond accordingly. From the simple “yes-no” language of neurons emerges enormous possibilities for behaviour. ie. Mostly excitatory input = ACTIVE, Mostly inhibitory input = NOT ACTIVE

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9
Q

What is the incoming signal to the neuron referred to as?

A

analog – graded signal (summation of input).

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10
Q

What is the outgoing signal of a neuron referred to as?

A

digital – on or off (binary).

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11
Q

What are glial cells and what are their functions?

A

Glia – support cells within the nervous system.

  1.   Act as “nerve glue” (glia = glue), holding neurons in place.
  2.   Supply nutrients to neurons.
  3.   Act as insulation around axons.
  4.   Remove pathogens and dead neurons.
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12
Q

What is an Ependymal cell?

A

Glial cell that makes and secretes cerebrospinal fluid (CSF).

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13
Q

What is hydrocephalus?

A

The resulting build up of pressure and swelling of the head; can happen if CSF is prevented from leaving the brain (usually due to a blockage in the fourth ventricle).

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14
Q

What are astrocytes?

A

Star shaped glial cells that are relatively symmetrical. Responsible for providing structural support for neurons, transporting substances between neurons and capillaries, scar tissue formation, sealing off a damaged area in the brain, promoting healing, and dilating blood vessels to provide more blood (and thus nutrients etc.) for active brain regions.

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15
Q

What is the blood brain barrier?

A

A protective barrier formed by astrocytes in combination with blood vessels. Prevents toxins etc. from entering the brain and also prevents useful substances from getting through (antibiotics
etc.).

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16
Q

What is the region of the brain that is not influence by the blood brain barrier and why?

A

Area postrema: serves as the bodies vomit reflex; checks the chemical constitution of the blood to see if there is anything toxic or harmful in it that needs to be ejected.

17
Q

What are Microglia?

A

Glial cells that originate in the blood as offshoot of the immune system. After damage microglia invade the area, providing growth factors, and cleaning up the mess. The removal of debris occurs through phagocytosis.

18
Q

What are Oligodendroglia cells?

A

Glial cell in the central nervous system that myelinates axons.

19
Q

What are Schwann cells?

A

Glial cell in the peripheral nervous system that myelinates axons.

20
Q

What is Myelin?

A

the glial coating that surrounds axons, providing insulation.

21
Q

What is the function of a sensory neuron?

A

Bring information to the central nervous system

22
Q

What is MS?

A

Central nervous system disorder that results from the loss of myelin around axons. Both sensory and motor pathways are affected and thus results in a huge number of symptoms, making it hard to diagnose. Repeated attacks of MS result in scar tissue formation.

23
Q

What are some factors that can lead to MS?

A
Environmental factors:
–  Lack of Vitamin D (the further away from the equator you are…)
–  Smoking
–  Exposure to solvents and toxins
–  Diet
–  Etc. 
Genetic component – you are more likely to get it if
someone in your family has it.
24
Q

True or false, glial cells have axons and dendrites.

25
What are some of the symptoms of a brain tumour?
Headaches, Seizures, Sensory loss, Fatigue, Depression, Etc.
26
What is a gliomas?
A brain tumour that arises from glial cells
27
What is a Meningioma brain tumour?
attach to the meninges, grow outside the brain, easy to deal with.
28
What is a metastatic brain tumour?
transfer of tumor cells from one region of the body to another, harder to treat.
29
Where are genetic mutations found?
In the normal population
30
What does BDNF stand for and what does it do?
Brain Derived Neurotrophic Factor; is a protein that is important for the health of neurons. Responsible for the growth, survival, and maintenance of neurons.
31
What are the two versions of the BDNF gene?
Val allele – most common. Met allele – produces a slightly less effective form of the BDNF protein. Approximately 1/3 of people inherit a copy of the Met allele.
32
What is the phenotype for the Met mutation in the BDNF protein?
Slightly reduced memory and hippocampus function.
33
What is found in the brains of people that have committed suicide.
Methylation is higher in the hippocampus
34
What does the glucocorticoid receptor gene do?
Mainly found in the hippocampus; Development •  Metabolism •  Immune response •  Stress •  Depression •  PTSD
35
True or false, child abuse leads to the methylation of the glucocorticoid receptor gene?
True
36
Define genetic engineering.
the removal, addition, or modification of genes.
37
What are 2 examples of transgenic technique.
Transgenic animals – addition of a gene | Knockout animals – selective removal of a gene
38
True or false, epigenetic modifications can be passed onto offspring.
True