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MycoViro > Chapter 35 - Hepatitis Viruses (RVSP) > Flashcards

Chapter 35 - Hepatitis Viruses (RVSP) Flashcards

(73 cards)

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0
Q

Classic signs of hepatitis virus infection

A

Jaundice and elevated liver enzymes

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1
Q

Main target of hepatitis viruses

A

Liver

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2
Q

Causes Hepa A

A

Picornavirus

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3
Q

Genus of Picornavirus

A

Hepatovirus

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4
Q

5 RNA hepatitis viruses

A
  • Hepatitis A
  • Hepatitis C
  • Hepatitis D
  • Hepatitis E
  • Hepatitis G
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5
Q

DNA hepatitis virus

A

Hepatitis B

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6
Q

Naked hepatitis viruses

A
  • Hepa A

- Hepa E

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7
Q

MOT of Hepa A

A

Fecal-oral route

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8
Q

Incubation period of Hepa A

A

About 1 month

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9
Q

Hepa viruses that only cause acute liver disease

A

Hepa A

Hepa E

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10
Q

Responsible for 40% of all hepatitis cases

A

Hepa A

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11
Q

Hepa A agent

A

HAV

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12
Q

Hepa A; detectable at onset of symptoms; persists throughout life

A

Anti-HAV

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13
Q

Hepa A; indicates recent infection; (+) 4-6 mts after infection

A

IgM anti-HAV

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14
Q

Causes Hepa B

A

Hepadnavirus

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15
Q

MOT of Hepa B

A

Parenteral

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16
Q

Incubation period of Hepa B

A

3 mts

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17
Q

3 morpholigic forms of Hepa B

A
  • small spherical particles
  • tubular/filamentous
  • large spherical virions (Dane particles)
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18
Q

4 phenotypes of HBsAg

A
  • adw
  • ayw
  • adr
  • ayr
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19
Q

HBsAg positive for 2 occasions at least 6 mts apart

A

Chronic carrier

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20
Q

3 clinical syndromes of Hepa B

A

Acute infection
Chronic infection
Primary hepatocellular carcinoma (PHC)

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21
Q

Hepa B syndrome; long incubation period, insidious onset

A

Hepa B acute infection

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22
Q

First sign of recovery for Hepa B acute infection

A

Renewed appetite

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23
Q

Hepa B syndrome; usually occurs after mild or inapparent illness

A

Hepa B chronic infection

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24
Detected in Hepa B chronic infection
Elevated liver enzymes
25
Latent period between HBV infection and PHC
9-35 years
26
Screening test for Hepa B
Agglutination test
27
Confirmatory tests for Hepa B
ELISA | PCR
28
Detects Hepa B Ag and Ab
ELISA
29
Detects Hepa B viral DNA
PCR
30
Pathology of PHC
- spotty parenchymal cell degeneration - diffuse lobular inflammatory reaction - disruption of liver cell cords
31
Hepa B agent
HBV
32
Hepa B surface Ag
HBsAg
33
Hepa B; indicates viral replication
HBeAg
34
Hepa B core Ag
HBcAg
35
Hepa B; indicates past infection; immune
Anti-HBs
36
Hepa B; suggests presence of HBV
Anti-HBe
37
Hepa B; indicates past infection
Anti-HBc
38
Hepa B; indicates high infectivity
HBeAg
39
Hepa B; indicates low infectivity
Anti-HBeAg
40
Hepa B; indicates new infection; acute
IgM anti-HBcAg
41
Hepa B; indicates old infection; chronic/resolving
IgG anti-HBcAg
42
Time when HBsAg is detectable
2 wks
43
Time when HBeAg is detectable
1 mt
44
Time when Anti-HBc is detectable
1.5 mts
45
Time when anti-HBe is detectable
5 mts
46
Time when anti-HBs is detectable
6 mts
47
Used for post-exposure or newborns of HBsAg (+) mothers and for mucosal exposure to secretions of individuals who are HBsAg (+)
Hepa B immune-globulin
48
Family of Hepa C causative agent
Flaviviridae
49
Genus of Hepa C causative agent
Hepacivirus
50
Accounts for 90% of non-A, non-B hepatitis infections
Hepa C
51
Major cause of post-transfusion hepatitis
Hepa C
52
MOT of Hepa C
Parenteral
53
2 clinical syndromes of Hepa C
- acute form | - chronic form
54
Mtd for Hepa C Ab detection
ELISA
55
Mtd for HCV-RNA
RT-PCR
56
Hepa C agent
HCV
57
Hepa C antibody
Anti-HCV
58
Hepa C syndrome; similar to acute Hepa A and B but inflammatory response is less and symptoms are milder
Acute form
59
Hepa C syndrome; more prevalent than HBV, often leads to cirrhosis
Chronic form
60
Composition of the Delta agent/Hepa D
HDAg surrounded by HBsAg envelope
61
Smallest Hepa virus
Hepa D
62
Hepa D; patients that are more likely to develop fulminant hepatitis
Delta agent carriers
63
Mtds for Hepa D Ag/Ab detection
ELISA | RIA
64
Mtd for Hepa D; to detect HDV-RNA
PCR
65
Hepa D agent
HDV
66
Delta Ag; detectable in early acute infection
HDAg
67
Hepa D; indicates past or present infection
Anti-HDV
68
Patients where Hepa E is more serious
Pregnant women
69
Mutant strain of HBV
Hepatitis F virus
70
Genome of Hepa F virus
dsDNA
71
Genome of Hepa G virus
ssRNA
72
Family of Hepa G virus
Flaviviridae

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