Chapter 4 Flashcards
6 main roles of proteins
-enzymes, storage and transport. physical cell support and shape, mechanical movement, decoding cell info, hormones and hormone receptors
largest and smallest protein name and size
smallest-insulin-51 amino acids long
largest-titin-30,000 amino acids
proteins have non covalent forces which means it
stabilizes the specific structures of the protein
proteins are marginally stable which means
stability is defined as the tendency to maintain their native conformation
the protein conformation with the lowest free energy is
the most stable and has the maximum number of weak interactions
The stability of a protein is not the sum of the energies of formation of weak interactions rather
the difference in the free energies of the folded and unfolded states
folded proteins are different because
they occupy a low energy state that makes the native structure most stable
what forms a protein to give it its “tertiary structure”
individual secondary structures form first then hydrophobic core condenses it all
protein folding and unfolding is
a cooperative process
denaturization
disruption of native conformation with loss of activity