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PCOL 2 > CHAPTER 43 (SAS 7 pt.1) _Beta-Lactam & Other Cell Wall- & Membrane-Active Antibiotics > Flashcards

CHAPTER 43 (SAS 7 pt.1) _Beta-Lactam & Other Cell Wall- & Membrane-Active Antibiotics Flashcards

1
Q

What generation of cephalosporin is CEFAZOLIN?

A

First generation

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2
Q

what generation of cephalosporins CEFADROXIL?

A

First generation

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3
Q

what generation of cephalosporin is CEFACLOR?

A

2nd generation

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4
Q

what generation of cephalosporins is CEFAMANDOLE?

A

2nd generation

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5
Q

what generation of cephalosporins is CEFONIZID?

A

2nd generation

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6
Q

what generation of cephalosporins is CEFUROXIME?

A

2nd generation

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7
Q

what generation of cephalosporins is CEFPROZIL?

A

2nd generation

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8
Q

what generation of cephalosporins is LORACARBEF?

A

2nd generation

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9
Q

what generation of cephalosporins is CEFORANIDE?

A

2nd generation

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10
Q

what generation of cephalosporins is CEFACLOR?

A

2nd generation

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11
Q

what generation of cephalosporins is CEFUROXIME?

A

2nd generation

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12
Q

what generation of cephalosporins is CEFPROZIL?

A

2nd generation

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13
Q

what generation of cephalosporins is CEFOXITIN?

A

2nd generation

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14
Q

what generation of cephalosporins is CEFOTETAN?

A

2nd generation

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15
Q

what generation of cephalosporins is MOXALACTAM?

A

Third generation

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16
Q

what generation of cephalosporins is CEF(T)AZIDIME?

A

Third generation

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17
Q

what generation of cephalosporins is CEFTIZOMINE?

A

Third generation

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18
Q

what generation of cephalosporins is CEF(T)RIAZONE?

A

Third generation

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19
Q

what generation of cephalosporins is CEFTIBUTEN?

A

Third generation

20
Q

what generation is CEFEPIME?

A

Fourth generation

21
Q

what generation of cephalosporins is CEFOPERAZONE?

A

Third generation

22
Q

what generation of cephalosporins is CEFOTAXIME?

A

Third generation

23
Q

what generation of cephalosporins is CEFIXIME?

A

Third generation

24
Q

what generation of cephalosporins is CEFPODOXIME PREXETIL?

A

Third generation

25
Q

what generation of cephalosporins is CEFDINIR?

A

Third generation

26
Q

what generation of cephalosporins is CEFDITOREN PIVOXIL?

A

Third generation

27
Q

what is the classification of AZTREONAM?

A

Monobactam

28
Q

Provide 3 beta-lactamase inhibitors

A

Tazobactam, Sulbactam, Clavulanic acid

29
Q

what are the carbapenems?

A

Doripenem, ertapenem, imipenem, meropenem

30
Q

Vancomycin is isolated from?

A

Amycolatopsis orientalis

31
Q

Vancomycin common reactions?

A

red man syndrome

32
Q

> is a semisynthetic lipoglycopeptide derived from vancomycin.
has two mechanisms of action. Like
vancomycin, telavancin inhibits cell wall synthesis by binding to
the d-Ala-d-Ala terminus of peptidoglycan in the growing cell
wall. In addition, it disrupts the bacterial cell membrane potential
and increases membrane permeability

A

Telavancin

33
Q

what is the classification of daptomycin?

A

lipopeptide

34
Q

Daptomycin is from?

A

Streptomyces roseosporus

35
Q

Bacitracin is from?

A

Bacillus subtilis

36
Q

Cycloserine is from?

A

Streptomyces orchidaceous

37
Q

what is the classification of Vancomycin?

A

Glycopeptide

38
Q

what is the moa of vancomycin?

A

inhibits cell wall synthesis by binding to the D-Ala-D-Ala terminus of nascent peptidoglycan

39
Q

what is the moa of daptomycin?

A

binds to cell membrane causing depolarization and rapid cell death

40
Q

what is the moa of penicillin, cephalosporins, carbapenems, monobactams?

A

inhibits cell wall synthesis

41
Q

These drugs have greater activity than penicillin against Gram-negative bacteria because of their enhanced ability to penetrate
the Gram-negative outer membrane.

A

Aminopenicillins, Carboxypenicillins, Ureidopenicillins (Extended-spectrum penicillins)

42
Q

developed to broaden the spectrum of penicillins against Gramnegative pathogens, including P aeruginosa.

A

Carboxypenicillins, carbenicillin, ticarcillin

43
Q

provide examples of b-lactamase inhibitors?

A

clavulanic acid, tazobactam, sulbactam, Avibactam

44
Q

is sometimes used to treat community-acquired pneumonia

A

Cefuroxime

45
Q

Inhibits cell wall synthesis by binding firmly to the
d-Ala-d-Ala terminus of nascent peptidoglycan pentapeptide

A

Vancomycin

45
Q

can cause myopathy

A

Daptomycin

PCOL 2 (6 decks)

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