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PCOL 2 > CHAPTER 54, ANTICANCER > Flashcards

CHAPTER 54, ANTICANCER Flashcards

1
Q

What is primary chemotherapy?

A

Patients with advanced cancer and alternative treatment is already invalid

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2
Q

what is neoadjuvant chemotherapy?

A

patients with localized cancer and alternative treatment is not that effective

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3
Q

what is adjuvant chemotherapy?

A

treatment following surgery in removal of tumor, with the intention to halt the relapse of the cancer.

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4
Q

Capacitabine

A

Anitmetabolites

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5
Q

Cladribine

A

Antimetabolites

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6
Q

Clofarabine

A

Antimetabolites

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7
Q

Cytarabine

A

Antimetabolites

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8
Q

Fludarabine

A

Antimetabolites

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9
Q

5-flourouracil

A

Antimetabolites

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10
Q

Gemcitabine

A

Antimetabolites

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11
Q

6-Mercaptopurine

A

Antimetabolites

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12
Q

Methotrexate

A

Antimetabolites

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13
Q

Nelarabine

A

Antimetabolites

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14
Q

Pralatrexate

A

Antimetabolites

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15
Q

6-thioguanine

A

Antimetabolites

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16
Q

Etoposide

A

Topoisomerase II Inhibitor

17
Q

tecans

A

Topoisomerase I inhibitor

18
Q

taxels

A

Taxanes

19
Q

Vinblastine, Vincristine, Vinorelbine

A

Vinca alkaloids

20
Q

Bleomycin

A

Antitumor antibiotic (G2-M phase)

21
Q

Ixabepilone, Eribulin

A

Antimicrotubule inhibitor

22
Q

other mycin

A

Anti-tumor antibiotics

23
Q

tins

A

Platinum analogs

24
Q

cins expt. Mitoxantrone

A

Anthracyclines

25
Q

Mechlorethamine,Chlorambucil,Cyclophosphamide, Bendamustine, Melphalan, Thiotepa, , Busulfan, Carmustine, Lomustine, Altretamine MOA’s?

A

Forms DNA Cross links, resulting in inhibition of DNA synthesis and function

26
Q

Temozolomide, zine’s MOA’s?

A

Methylates DNA and inhibits DNA synthesis and function

27
Q

tin’s MOA’s?

A

Forms intrastand and interstand DNA cross-links; binding to nuclear and cytoplasmic proteins

28
Q

where is Vinblastine from?

A

Vinca rosea

29
Q

what is the vinca alkaloids MOA’s?

A

inhibits mitosis

30
Q

what is the MOA of etoposide?

A

inhibit topoisomerase II

31
Q

What is the MOA’s of tecan’s?

A

inhibit topoisomerase I

PCOL 2 (6 decks)

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