Chapter 5 - Pharmacodynamics Flashcards Preview

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Flashcards in Chapter 5 - Pharmacodynamics Deck (10)
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1
Q

Pharmacodynamics

A

How the drugs exerts its effect on the body; how the medicine changes the body

2
Q

Therapeutic index

A

Measure of a drug’s safety margin; the higher the value, the safer the drug

3
Q

Interpatient variability in response to drugs can best be understood by examining a …

A

Frequency distribution curve

4
Q

Frequency distribution curve example-

A

Response desired is a reduction of 20mmHg in systolic bp

Few patients only need 10 mg of drug to reach this, but a 50mg dose gave a larger number of patients this level and a few needed as much as 90mg dose to reach a 20mmHg reduction

5
Q

The — the therapeutic index the — the drug.

A

Higher, safer

6
Q

Dose response relationship

A

Phase 1 - low doses; the flat line of the graph indicates that few target cells have been affected by the drug

Phase 2 - giving more drug results in more effect; and lowering drug dose gives less effect

Phase 3 - plateau; more of a drug will not produce further therapeutic effects, potentially toxic

7
Q

Drug that produces the same type of response as the endogenous substance

A

Agonist

8
Q

Example of agonist drug

A

Heroin - full opiate agonist

9
Q

Antagonist drug

A

Bind to and occupy receptor to prevent endogenous chemical from binding; compete with agonist for the receptor!

Narcan is an example of an antagonist; binding to opioids receptors without acting on them

10
Q

Partial agonist

A

Produce a weaker, less effective response than a full agonist

Suboxone is a partial agonist