Chapter 50: Drugs for Hypertension Flashcards

(42 cards)

1
Q

what are the 4 risk factors for hypertension

A
  • diabetes mellitus
  • chronic kidney disease
  • low level of consumption of fresh fruits and vegetables
  • sedentary behaviour
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

out of office measurement of blood pressure is reccomended for all adults with

A
  • high BP in office to rule out white coat hypertension
  • suspected hypertension yo rule out masked hypertension
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

normal blood pressure

A

systolic BP <120 and diastolic BP < 80

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

elevated BP

A

systolic BP of 120-129 and diastolic <80

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

hypertension stage 1

A

systolic BP 130-139 or dialstolic 80-89

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

hypertesnion stage 2

A

systolic BP >140 or diastolic BP >90

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what is the target blood pressure for someone with diabetes

A

<130

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

consequences of hypertension

A
  • increased risk of stroke and ischemic heart disease mortality
  • for every 20 systolic BP; risk of dying doubles
  • for every 10 diastolic BP; risk doubles
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Primary (essential) hypertension

A
  • no identifiable cause
  • chronic, progressive disorder
  • population: older adults, african Canadians, postmenopausal women
  • treated no cured
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

secondary hypertension

A
  • identifiable primary cause
  • possible to treat the cause directly
  • some individuals can be cured (hypertension during pregnancy or a tumour)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

masked hypertension

A
  • patients BP is less than 140/90 in a medical setting but is hypertensive at home
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

white coat hypertension

A
  • patients BP is less than 140/90 at home but is hypertensive in a medical setting
  • associated with anxiety and nervousness
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

hypertension is a significant risk factor for

A
  • cerebrovascular disease
  • coronary artery disease
  • heart failure
  • renal failure
  • peripheral vascular disease
  • dementia
  • atrial fibrillation
  • kidney disease
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

major cardiovascular risk factors

A
  • cigarette smoking
  • physical inactivity
  • dyslipidemia
  • diabetes
  • microalbuminuria
  • advances age (older 55 men; older 65 women)
  • family history
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

lifestyle modifications for hypertension

A
  • sodium restriction
  • DASH eating plan
  • alcohol restriction
  • aerobic exercise / weight reduction
  • smoking cessation
  • maintenance of potassium and calcium intake
  • relaxation therapies
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

sodium intake should be

A

<2000 mg/day

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

how much physical activity should someone do

A

30-60 min 4-7 days/week

18
Q

appropriate alcohol intakw

A

0-2 drinks per day

19
Q

stress management

A

CBT and relaxation techniques

20
Q

what is healthy BMI

A

18.5-24.9kg/m

21
Q

healthy waist circumference

A

men <102cm
women <88cm

22
Q

arterial pressure =

A

cardiac output x peripheral resistance

23
Q

cardiac output is influenced by

A
  • heart rate
  • myocardial contractility
  • blood volume
  • venous return
24
Q

what are the systems that help regulate blood pressure

A
  • SNS: sympathetic baroreceptor reflex
  • RAAS
  • kidney: renal regulation of blood pressure
25
what are the sites of drug action
- brainstem - sympathetic ganglia - terminals of adrenergic nerves - beta 1 adrenergic receptors on the heart - alpha 1 adrenergic receptors on blood vessels - renal tubules - RAAS
26
what are the classes of hypertensive drugs
- Diuretics - Sympatholytics (antiadrenergic drugs) - direct acting vasodilators (hydralazine and minoxidil) - calcium channel blockers (diltiazem, verapamil) - drugs that supress RAAS (ACE inhibitors, ARBS, aldosterone antagonists)
27
patients without compelling inducations will be put on which drug
long-acting thiazide-like diuretics - Indapamide or single pill combinations
28
patients with compelling indications will be put on which drugs
- beta blocker - ACE - ARB - CCB - duiretic
29
What drugs should be used in patients with renal disease
ACE or ARB
30
what drugs should be used in patients with diabetes
may need multiple drugs
31
what drugs should be used in african Canadians
diuretics are first choice
32
what drugs should be avoided in females
ACE/ARB
33
what drugs should be used in older adults
- start with low dose diuretic
34
what are ways to promote adherence
- educate the patient - teach self-monitoring - minimize side effects - establish a collaborative relationship (patient centered care) - simplify the regimen - other measures (motivational interviewing)
35
possible reasons for poor response to treatment
- adherence (dietary, activity, meds) - obestity, tobacco, alcohol, sleep apnea, chronic pain - suboptimal treatment dose - volume overload- high sodium intake - drug interactions
36
drugs for hypertensive emergencies
- sodium nitroprusside [Nitropress] - Labetalol
37
sodium nitroprusside [nitropress]
- continuous IV infusion via pump - direct acting vasodilator
38
Labetalol
- alpha/beta blocker - slow IV
39
what drugs shoul dbe used for hypertension during pregnancy
- labetolol - methydopa - LA nifedipine - beta blockers
40
what drugs are contradicted during pregnancy
- ACE - ARB - DRI
41
what drugs are use for preeclampsia and eclampsia
- hydralazine - magnesium sulfate
42
what may aggravate low blood pressure q
- hot tubes, showers, baths, hot weather, prolonged sitting or standing, physical exercise, and alcohol ingestion