CHAPTER 58: Bleeding and Thrombosis

Question 1

I

Answer 1

Fibrinogen

Question 2

II

Answer 2

Prothrombin

Question 3

IIa

Answer 3

thrombin

Question 4

III

Answer 4

Tissue thromboplastin

Question 5

IV

Answer 5

Ionized calcium (Ca2+)

Question 6

V

Answer 6

Proaccelerin

Question 7

VII

Answer 7

Proconvertin

Question 8

VIIa

Answer 8

Convertin

Question 9

IX

Answer 9

Antihemophilic factor B; plasma thromboplastin component (PTC); Christmas factor

Question 10

X

Answer 10

Stuart–Prower factor

Question 11

XI

Answer 11

Plasma thromboplastin antecedent

PTA

Question 12

XII

Answer 12

Hageman factor

Question 13

XII

Answer 13

Fibrin-stabilizing factor (FSF)

Question 14

Va

Answer 14

Accelerin

Question 15

Prekallikrein

Answer 15

Fletcher factor

Question 16

promote coagulation, called

Answer 16

procoagulants,

Question 17

inhibit coagulation

Answer 17

anticoagulants

Question 18

coagulants normally predominate, so that the blood does not coagulate while it is circulating in the blood vessels.

Answer 18

anticoagulants

Question 19

formed continually by the liver, and it is continually being used throughout the body for blood clotting

Answer 19

Prothrombin

Question 20

is required by the liver for normal for- mation of prothrombin as well as for formation of a few other clotting factors

Answer 20

Vitamin K

Question 21

is a high-molecular-weight protein (MW = 340,000) that occurs in the plasma in quantities of 100 to 700 mg/dl. formed in the liver,

Answer 21

Fibrinogen

Question 22

is a protein enzyme with weak proteolytic capabilities. It acts on fibrinogen to remove four low-molecular- weight peptides from each molecule of fibrinogen

Answer 22

Thrombin

Question 23

activates the fibrin-stabilizing factor

Answer 23

Thrombin

Question 24

operates as an enzyme to cause covalent bonds between more and more of the fibrin monomer molecules, as well as multiple cross- linkages between adjacent fibrin fibers, thus adding tremendously to the three-dimensional strength of the fibrin meshwork.

Answer 24

fibrin-stabilizing factor XIII

Question 25

composed of a meshwork of fibrin fibers running in all directions and entrapping blood cells, platelets, and plasma

Answer 25

Blood Clot

Question 26

composed especially of phospholipids from the membranes of the tissue plus a lipoprotein complex that functions mainly as a proteolytic enzyme.

Answer 26

tissue thromboplastin Factor III

Question 27

activates factor VII to VIIa (intrinsic pathway)

Answer 27

Factor III

Question 28

activates factor X to Xa

Answer 28

Factor VIIa plus factor IV

Question 29

Factor Xa plus TF or FACTOR 3 plus Factor V is equals to?

Answer 29

prothrombin activator

Question 30

catalyses the cleaving of fibrinogen to fibrin?

Answer 30

thrombin

Question 31

prothrombin to IIa what complex catalyses?

Answer 31

prothrombin activator

Question 32

prevention of blood loss

Answer 32

HEMOSTASIS

Question 33

Procoagulant or Anticoagulant • platelet adhesion and aggregation

Answer 33

Procoagulant

Question 34

Procoagulant or Anticoagulant | • fibrin clot formation

Answer 34

Procoagulant

Question 35

Procoagulant or • Prostacyclin, NO

Answer 35

Anticoagulant

Question 36

Procoagulant or Anticoagulant • natural inhibitors of coagulation and fibrinolysis

Answer 36

Anticoagulant

Question 37

Procoagulant or Anticoagulant • ectoADPase/CD39

Answer 37

Anticoagulant

Question 38

Procoagulant or Anticoagulant • Heparan proteoglycans

Answer 38

Anticoagulant

Question 39

• Thrombomodulin Procoagulant or Anticoagulant

Answer 39

Anticoagulant

Question 40

• Antithrombin Procoagulant or Anticoagulant

Answer 40

Anticoagulant

Question 41

• Major plasma protease inhibitor of thrombin and other clotting factors in coagulation.

Answer 41

Antithrombin(Antithrombin III)

Question 42

• Neutralizes thrombin and the other activated coagulation factors by forming a complex bet the ACTIVE SITE of the enxyme and the REACTIVE CENTER of antithrombin.

Answer 42

Antithrombin(Antithrombin III)

Question 43

• Plasma glycoprotein that becomes anticoagulant when it is activated by thrombin that occurs on thrombomodulin

Answer 43

Protein C

Question 44

o transmembrane proteoglycan-binding site for thrombin on endothelial cell surfaces • Cleaves and inactivate activated factors V and VIII

Answer 44

• Thrombomodulin

Question 45

o Cofactor which accelerates action of Protein C

Answer 45

• Protein S

Question 46

• Megakaryocyte

Answer 46

Platelets

Question 47

* Megakaryocyte | * Normal Value:

Answer 47

150,000–450,000/L

Question 48

life span of platelets?

Answer 48

7 to 10days in circulation

Question 49

o Major regulator of platelet production o synthesized in the liver o ↑ synthesis within flammation

Answer 49

• Thrombopoietin (TPO)

Question 50

- large multimeric protein present in both plasma and extracellular matrix of the subendothelial vessel wall - serves as the PRIMARY MOLECULAR GLUE

Answer 50

o Von Willebrand Factor