Chapter 7 Flashcards
(47 cards)
Fluid mosaic model
Consists of phospholipids arranged in a bilayer (fluid) and various proteins inserted in the lipid bilayer (mosaic of proteins)
Fluidity of membranes
Membranes are held together mainly by weak hydrophobic interactions.
Membrane structure
As temps cool, membranes become less fluid and more solid. Fluidity depends on the types of lipids.
Cholesterol within the animal cell membrane
Cholesterol reduced membrane fluidity at moderate temperatures, but at low temperatures hinders solidification
Membrane proteins and their functions
Membranes contains a variety of different proteins, embedded in the fluid matrix of the lipid bilayer. Proteins determine most of the membranes specific functions
Peripheral proteins
Bound to the membrane surface
Integral proteins
Penetrate the hydrophobic core
Transmembrane proteins
Integral proteins that span the membrane
The hydrophobic regions of an integral protein
Consist of one or more stretches of nonpolar amino acids, often cooled into alpha helices
6 major functions of membrane proteins
- Transport
- Enzymatic activity
- Signal transduction
- Cell-cell recognition
- Intercellular joining
- Attachment to the cytoskeleton and extra cellular matrix (ECM)
The role of membrane carbohydrates in cell-cell recognition
Carbs, on the extra cellular surface of the plasma membrane are used in cell recognition. (Glycolipids and glycoproteins). Membrane carbs vary among species, individuals, and even cell types in an individual.
Glycolipids
Membrane carbohydrates covalently bonded to lipids
Glycoproteins
Carbs bound to proteins
Synthesis and sidedness of membranes
Membranes hace distinct inside and outside faces. The asymmetrical distribution of P, L, and associated carbs in the plasma membrane is determined when the membrane is built by the ER and Golgi apparatus
Membrane structure results in selective permeability
Plasma membranes are selectively permeable, regulating the cells molecular traffic
Hydrophobic (nonpolar) molecules
Can dissolve in the lipid bilayer and pass through the membrane rapidly
Hydrophilic molecules
Including ions and polar molecules do not cross the membrane easily
Diffusion
The tendency for molecules to spread out evenly into the available space
Membrane structure results in selective permeability
Substances diffuse down their concentration gradient from high to low concentration. No work has to be done to move substances down the concentration gradient
Passive transport
The diffusion if a substance across a biological membrane because no energy is expended by the cell to make it happen
Osmosis
The diffusion of water across a selectively permeable membrane
Effects of osmosis on water balance
Water diffuses across a membrane from the region of lower solute concentration to the region of higher solute concentration until the solute concentration is equal on both sides
Tonicity
The ability of a surrounding solution to cause a cell to gain or lose water
Isotonic solution
Equal solute concentration on both sides of plasma membrane. No net water movement