Chem-Lipids

Question 1

mechanisms of hypercholesterolemia

five

Answer 1

1. increased production
2. decreased lipolysis or abnormal processing
3. inherited
4. decreased excretion = cholestasis
5. endocrine disorders

Question 2

causes of hypercholesterolemia due to increased production?

Answer 2

• postprandial - usually mild
• part of nephrotic syndrome (endpoint of PLN, concurrent with proteinuria, hypOalbuminemia)

Question 3

causes of hypercholesterolemia as a result of decreased lipolysis/abnormal lipid processing?

Answer 3

• hypothyroidism
• nephrotic syndrome

Question 4

what breeds have genetic predispositions to hyperlipidemia?

Answer 4

briards, mini schnauzers

Question 5

endocrine disorders that can lead to hypercholesterolemia?

Answer 5

• hypothyroidism
• pancreatitis
• diabetes mellitus
• Cushings

Question 6

mnemonic for causes of hypercholesterolemia?

Answer 6

Having Pepporoni Pizza at Night Causes Instant Death

• Hypothyroidism
• Pancreatitis
• Postprandial
• Nephrotic syndrome
• Cholestasis
• Cushings
• Idiopathic, Inheritied
• Diabetes

Question 7

Causes of hypocholesterolemia?

Answer 7

MANL
* Malabsorption/Maldigestion (PLEs, EPI)
* Addison’s disease
* Neoplasia (especially histiocytic sarcoma)
* Liver insufficiency, dz, or failure