Chem MOAs Flashcards
(21 cards)
Botulinus toxin action
BLOCKs release of Ach from PREsynapic terminals
- *“from bad BOTtle of food”
- B–> Botulin BLOCKS release”
Botulinus toxion’s effect on NM transmission
total blockade
flaccid paralysis
“floppy baby”
Curare (arrow poison) action
Competes with Ach for receptor on MOTOR end plate
C–> Curare COMPETES with
Curare’s effect on NM transmission
decrease EPP
Paralysis of resp muscles –> death
Neostigmine action
inhibits acetyl cholinesterase
Neostigmine’s effect on NM transmission
prolongs and enhances action of ACh at muscle end plate
Hemicholinium’s action
Blocks re-uptake of choline into presynaptic terminal
Hemicholinium’s effects on NM transmission
Depletes ACh stores from presynamptic terminals
Aminoglycosides action
and Lamort Eaton Syndrome
Antibodies BLOCK Ca ++ channels
Aminoglycosides Effect on NM transmission
and Lamort Eaton Syndrome
No release of ACh
Black widow spider venom action
excessive release of ACh
Black widow spider venom effects on NM Transmission
convulsions
antibody-induced degradation of ACh receptors is seen in
myasthenia gravis
Neurotransmitter synthesis of Acetylcholine:
Acetyl CoA + Choline —–> acetylcholine
Neurotransmitter synthesis of Norepinephrine:
Tyrosine --> L-Dopa ---> Dopamine--> Norepinephrine---> Epinephrine
Neurotransmitter synthesis of Dopamine:
Tyrosine –>
L-Dopa —>
Dopamine
Neurotransmitter synthesis of Epinephrine:
Tyrosine --> L-Dopa ---> Dopamine--> Norepinephrine---> Epinephrine
The rate limiting step in NT synthesis of Dopamine/Nor/Epi is:
- Tyrosine hydoxylase
Norepinephrine is metabolized by
MAO monoamine oxidase
Small molecule, rapidly acting NTs are:
- Ach,
- Aspartame,
- Dopamine,
- Epi,
- GABA,
- Glycine,
- Glutamate,
- Histamine,
- Norepi,
- Nitric oxide (NO)
Neuropeptides, slowly acting transmitters are:
- Hypothalamic hormones
- Pituitary hormones
- Peptides: Substance P, gastrin, Insulin, glucagon
- Angiotensin II
- Bradykinin
