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Inflammation > Chemical Mediators > Flashcards

Flashcards in Chemical Mediators Deck (19)
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1

arachadonic acid metabolites

formed via cyclooxygenase and lipooxygenase; include prostaglandins, thromboxanes, leukotrienes and lipoxins

2

cyclooxygenases

part of arachadonic acid metabolite; includes prostaglandin and thromboxane; involved in pain, fever, vasodilation, increased permeability, and promotes platelet aggregation

3

lipooxygenases

part of arachadonic acid metabolite; includes leukotrienes and lipoxins; mediates chemotaxis, vasoconstriction, bronchospasm, increase vascular permeability

4

vasoactive amines

preformed and released quickly from mast cells (histamine) and platelets (serotonin)

5

histamine

part of vasoactive amine; released from mast cells; vasodilation, increase vascular permeability

6

serotonin

part of vasoactive amine; released from platelets; vasodilatation, increases vascular permeability

7

complement system

found in plasma; function in innate and adaptive immunity (against microbes); acute inflammatory processes: vascular permeability, vasodilation, leukocyte adhesion, chemotaxis, activation and phagocytosis; C3 and C5 are most important (medically) of the inflammatory mediators

8

kinin system

increase vascular permeability, vasodilation, smooth muscle contraction and elicits pain--bradykinin (preformed in plasma)

9

cytokines

proteins produced by many cell types (including lymphocytes and macrophages) which have multiple functions; interleukin 1 and TNF are both involved with "acute phase" reaction-fever, loss of appetite, neutrophil release, chemotaxis mediation

10

interleukin - 1

part of cytokine system--mediates chemotaxis, induces fever, induces WBC release from bone marrow, promotes histamine release

11

tumor necrosis factor (TNF)

part of cytokine system--induces fever, induces WBC release from bone marrow

12

clotting system

thrombin causes development of fibrin (formation of clot); breakdown of fibrin creates FSPs (fibrin split products) which have permeability inducing properties

13

NItric Oxide

released from macrophages and endothelial cells; involved in tissue destruction (cytotoxin) and vasodilation

14

things that increase vascular permeability

bradykinin, C3, C5, histamine, serotonin, prostaglandins, leukotrienes

15

things that cause vasodilation

bradykinin, histamine, serotonin, prostaglandins, NO

16

things that elicit pain

bradykinin, prostaglandin

17

histamine release promoters

C3, C5, interleukin

18

fever inducers

interleukin, tumor necrosis factor (TNF)

19

chemotaxis mediators

C5, C3, interleukin, leukotriene, prostaglandin