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Flashcards in Chemo Drugs Deck (10)
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1

Agents Directly Modifying DNA Structure

Anthracycline Antibiotics

Bleomycin

Cisplatin/Cyclophospamide

2

Antimetabolites

5-FU
Methotrexate

– interfere with precursors to purine and pyrimidine synthesis

3

Microtubule Inhibitors

Vinca alkaloids and Taxanes

4

Doxorubicin and Daunorubicin

Anthracycline Antibiotic

The molecule first intercaltes in DNA, stopping transcription and replication.

The intercalated antibiotic molecule physically interferes with
Topoisomerase II activity which normally repairs DNA

Generate free radicals by binding to Fe2+ that lead to apoptosis after DNA damage.

5

Bleomycin

Glycopeptide antibiotic

Produces free radicals with Fe2+

Attack phosphodiester bonds in the DNA
strand resulting in a cutting or scission of DNA strands.

Most effective during G2

Pulmonary
toxicity

6

Cytotoxic alkylating agents

Covalently Bind to DNA cross linking it

The maximal effect of alkylating agents is during ‘S’ phase.

7

Methotrexate

Methotrexate acts by inhibiting DHFR to interfere with folate metabolism

Folates are vital for production of purine nucleotides and thymidilate

Stopping DNA and RNA synthesis

Antimetabolites are cell cycle specific in their action – ‘S’ phase

8

5 fluro uracil

5-FU is an analogue of the pyrimidine base uracil. This inhibits Thymidilate synthesis

Thymidine-less cell death

Antimetabolites are cell cycle specific in their action – ‘S’ phase

9

Vinca alkaloids

Vincristine
and vinblastine

Specifically binding with the B-tubulin subunit that then
prevents formation of the microfilaments that make up the microtubule. This means the
mitotic spindle does not form and the cell cycle is arrested in mitotic metaphase.

10

Taxanes

Paclitaxel

Binding stabilises
the microtubules and inhibits their disassembly. These microtubules are rendered nonfunctional
and they cannot disassemble to pull the chromosome apart