chemo drugs Flashcards
(52 cards)
common ADRs of chemo drugs
Nausea/Emesis Anorexia Alopecia Myelosuppression Secondary malignancies
ways to give chemo
IV, oral, intravesical, intraperitoneal
alkylating drugs
cyclophosphamide
cisplatin
indications for cyclophosphamide
- CA
- nephrotic syndrome
- GPA
- SLE
cyclophosphamide ADRs
- sterility
- hemorrhagic cystitis *evaluated very aggressively!
cisplatin ADRs
- nephrotoxicity
- ototoxicity
monitoring for cisplatin
audiology
renal function
anti-metabolites
- MTX
- 5-FU
- cytarabine
MTX ADRs
- stomatitis
- pulmonary toxicity
- hepatotoxicity
reversal agents for MTX
leucovorin + glucarpidase
MTX interactions
- drugs that affect renal function (diuretics, NSAIDs, cyclosporine)
- other antimetabolites (TMP-SMX)
- PIs increase MTX (toxicity)
5-FU ADRs
- stomatitis
- enterocolitis
- hyperpigmentation
cytarabine ADRs
cytarabine syndrome
cerebellar toxicity
cytarabine syndrome characteristics & when it occurs
fever, bone pain, chest pain, MP rash, myalgia, malaise, conjunctivitis
occurs 6-12 hours following administration
how do you manage cytarabine syndrome
corticosteroids
chemo antibiotics
- doxorubicin
- bleomycin
doxorubicin baseline monitoring
cardiac eval via ECG, MUGA +/- ECHO
doxorubicin ADR
cardiotoxicity
radiation recall
who is doxorubicin contraindicated in
if LVEF is <30-40%
when can doxorubicin cardiotoxicity present
may be delayed for 7-8 years after tx
what is radiation recall
- occurs with doxorubicin in pts who have had prior XRT
- warmth, erythema, dermatitis at prior radiation port –> severe desquamation/ulceration
when does radiation recall occur
5-7 days after administration of doxorubicin
bleomycin ADRs
- rash, striae, induration, hyperkeratosis, vesiculation, peeling = most common on palmar/plantar surfaces
- acute/chronic interstitial pneumonitis > pulmonary fibrosis
major thing to monitor with Bleomycin
PFTs, CXR
