Exam 3 Flashcards
1
Q
tetracycline
A
tetracycline ABX - 30s ribosomal inhibition
URTI, NGU, CAP, tick-borne disease
2
Q
minocycline
A
tetracycline ABX - 30s ribosomal inhibition
acne
3
Q
doxycycline
A
tetracycline ABX - 30s ribosomal inhibition
URTI, NGU, CAP, tick-borne dz
4
Q
tigecycline
A
synthetic tetracycline - 30s ribosomal inhibition
nosocomial infections
5
Q
omadacycline
A
synthetic tetracycline - 30s ribosomal inhibition
nosocomial infections
6
Q
evravacycline
A
synthetic tetracycline - 30s ribosomal inhibition
nosocomial infections
7
Q
azithromycin
A
macrolide ABX - 50s ribosomal inhibition
URTI, CAP, NGU, shigella in kids, campy
8
Q
clarithromycin
A
macrolide ABX - 50s ribosomal inhibition
mainly h. pylori
9
Q
erythromycin
A
macrolide ABX - 50s ribosomal inhibition
DM gastroparesis
10
Q
fidaxomicin
A
unique macrolide - inhibits RNA polymerase
c.diff
11
Q
clindamycin
A
lincosamide ABX - 50s ribosomal inhibition
anaerobic abscesses/infection; strep pharyngitis & SSTI in b-lactam allergy
12
Q
linezolid
A
oxazolidinone ABX - 50s ribosomal inhibition
MRSA, VRE
13
Q
tedizolid
A
oxazolidinone ABX - 50s ribosomal inhibition
MRSA, VRE
14
Q
gentamycin
A
aminoglycoside ABX - 30s ribosome inhibition
aerobic GNB - synergistic w cell wall agents against enterococci
15
Q
tobramycin
A
aminoglycoside ABX - 30s ribosomal inhibition
aerobic GNB - synergistic w cell wall agents against enterococci
16
Q
amikacin
A
aminoglycoside ABX - 30s ribosomal inhibition
MDR GNB
17
Q
lefamulin
A
pleuromutilin ABX - 50s ribosomal binding to inhibit protein synthesis
CAP
18
Q
ciprofloxacin
A
non-respiratory FQ ABX - inhibits bacterial DNA topoisomerase to prevent DNA replication
upper & lower UTI, travelers diarrhea, enteric infection
19
Q
levofloxacin
A
respiratory FQ ABX - inhibits bacterial DNA topoisomerase to prevent DNA replication
upper & lower UTI, travelers diarrhea, enteric infections, *URI/LRTIs
20
Q
moxifloxacin
A
respiratory FQ ABX - inhibits bacterial DNA topoisomerase to prevent DNA replication
upper & lower UTI, travelers diarrhea, enteric infections, *URI/LRTIs
21
Q
delafloxacin
A
MRSA FQ - inhibits bacterial DNA topoisomerase to prevent DNA replication
MRSA
22
Q
metronidazole
A
nitromidazole ABX - causes loss of helical DNA structure & strand breakage
bacterial vaginosis, CDI, trich/giardia, intraabdominal abscesses
23
Q
tinidazole
A
nitromidazole ABX
24
Q
secnidazole
A
nitromidazole ABX
25
TMP-SMX (Bactrim)
anti-metabolite ABX - inhibits dihydrofolic acid synthesis; inhibits dihydrofolic acid reduction
PCP/PJP, lower UTI, MRSA suppression/treatment
26
nitrofurantoin
```
inhibits bacterial enzyme acetyl coA
urinary pathogens (GNB + enterococci) --> lower UTI & prophylaxis of recurrent UTI
```
27
fosfomycin
```
binds pyuvyl transferase
urinary pathogens (GNB + enterococci) --> uncomplicated cystitis
```
28
rifaximin/rifamycin
inhibits bacterial RNA synthesis
noninvasive E.coli causing travelers diarrhea
prevention of hepatic encephalopathy
29
chloramphenicol
CNS infections
30
rifampin
inhibits RNA polymerase
| active TB tx, latent TB, meningococcal meningitis
31
isoniazid
inhibits synthesis of mycolic acid
| latent TB*, active TB
32
pyrazinamide
active TB component
33
ethambutol
inhibits cell wall synthesis
34
caspofungin
echinocandin antifungal - inhibits synthesis of B-13 glucan - cell wall component
invasive candida infection, aspergillus
35
michafungin
echinocandin antifungal - inhibits synthesis of B-13 glucan - cell wall component
invasive candida infection, aspergillus
36
anidulafungin
echinocandin antifungal - inhibits synthesis of B-13 glucan -- cell wall component
invasive candida infection, aspergillus
37
amphotericin B
polyene antifungal - binds to ergosterol -- alters cell membrane permeability
aspergillosis, zygomycosis, histoplasmosis, blastomycosis, coccidiomycosis, Cryptococcus, sporotricosis
38
nystatin
polyene antifungal - binds to ergosterol -- alters cell membrane permeability
OP candidiasis, intertrigo
39
oral antifungals
clotrimazole, miconazole
40
skin antifungals
ketoconazole, clotrimazole, econazole, miconazole
41
vaginal antifungals
clotrimazole, miconazole, tioconazole, terconazole
42
old systemic antifungals
fluconazole, ketoconazole, irtraconazole
43
fluconazole
azole antifungal - inhibits CYP450 enzyme which converts lanosterol to ergosterol (cell membrane)
candida infections
44
terbinafine
allylamine antifungal - inhibits sequalene epoxidase which inhibits ergosterol synthesis (cell membrane)
cutaneous dermatophyte infections, onchyomycosis
45
anti-HSV/VZV drugs
acyclovir, valacyclovir, famciclovir
46
acyclovir
anti-HSV/VZV - competes with deoxyguanoside for viral DNA polymerase & is incorporated into viral DNA --> DNA chain termination
primary & recurrent genital HSV, orolabial HSV, encephalitis HSV, primary & secondary VZV
47
valacyclovir
anti-HSV/VZV - competes with deoxyguanoside for viral DNA polymerase & is incorporated into viral DNA --> DNA chain termination
primary & recurrent genital HSV, herpes zoster infection (secondary VZV)
48
famciclovir
anti-HSV/VZV - competes with deoxyguanoside for viral DNA polymerase & is incorporated into viral DNA --> DNA chain termination
primary & recurrent genital HSV, herpes zoster infection (secondary VZV)
49
anti-CMV drugs
ganciclovir, valganciclovir, letermovir
50
ganciclovir
anti-CMV drug
| active retinitis, suppression of retinitis, colitis/esophagitis, prevention of CMV in transplant
51
valganciclovir
anti-CMV drug
| induction & maintenance of CMV retinitis, prevention of CMV disease following transplant
52
letermovir
anti-CMV drug
| prophylaxis of CMV infection & disease in CMV + adults of an allogenic HCT
53
amantadine
amantane/M2 inhibitors - anti-influenza; prevents viral penetration into host via blocking viral uncoating of influenza A
parkinsonism, drug-induced EPS
54
rimantadine
amantane/M2 inhibitors
55
oseltamivir
neuraminidase inhibitor - anti-influenza
| chemoprophylaxis of influenza A & B; treatment of influenza A&B & swine/influenza
56
zanamivir
neuraminidase inhibitor - anti-influenza
| amantadine/rimantadine & oseltamivir-resistance strains
57
peramivir
neuraminidase inhibitor - anti-influenza
| IV anti-influenza in critical illness
58
baloxavir
polymerase acidic endonuclease inhibitor - blocks viral replication
influenza A&B, NA inhibitor resistant strains
59
emtricitabine (FTC)
pyrimidine cytosine analog - inhibition of viral replication
anti-HIV (+HBV activity
60
Tenofovir
purine adenine analog NRTI - inhibition of viral replication
anti-HIV (+HBV activity)
61
efavirenz (EFV)
1st generation NNRTI
| anti-HIV
62
rilpivirine
2nd generation NNRTI
| anti-HIV
63
darunavir
protease inhibitor - formation of immature, noninfectious viral particles
anti-HIV drug
64
ritonavir & cobicistat
added to PI (darunavir) to decrease dosage frequency of PI
65
INSTI drugs
- gravir
66
enfuvirtide
fusion inhibitor
| anti-HIV
67
maraviroc
entry inhibitor
| anti-HIV
68
ibalizumap-uiyk
post-attachment inhibitor
| MDR anti-HIV
69
sofosbuvir-velpatasvir
anti-HCV
70
glecaprevir-pibrentasvir
anti-HCV
71
scopolamine
anticholinergic/M1 receptor antagonist
| prophylaxis of motion sickness, dry OP secretions
72
dimenhydrinate
antihistamine/H1 receptor antagonist
| motion sickness
73
meclizine
antihistamine/H1 receptor antagonist
| motion sickness, vertigo management
74
promethazine
phenothiazine derivative - blocks D2, H1 and alpha
| migraines, allergic conditions, antiemetic, motion sickness
75
prochlorperazine
phenothiazine - Dopamine antagonist; blocks D1 & D2 and a-adrenergic blocking
antiemetic
76
droperidol
butyrophenone - dopamine antagonist; blocks D1 & D2 receptors
77
metoclopramide
benzamide - dopamine antagonist; blocks D2, serotonin + enhances response to Ach in UGI tissues
chemo-induced emesis, PONV, DM gastroparesis
78
trimethobenzamide
benzamide - dopamine antagonist; blocks D2, serotonin
79
ondansetron
1st gen serotonin antagonist - blocks in small bowel, vagus nerve, CTZ
PONV, CIE, nausea from irradiation, kids in ED with GE
80
granisetron
1st gen serotonin antagonist - blocks in small bowel, vagus nerve, CTZ
PONV, CIE, nausea from irradiation, kids in ED with GE
81
dolasetron
1st gen serotonin antagonist - blocks in small bowel, vagus nerve, CTZ
PONV, CIE, nausea from irradiation, kids in ED with GE
82
palonosetron
2nd gen serotonin antagonist - blocks in small bowel, vagus nerve, CTZ
CINV
83
management of N/V in pregnancy
lifestyle --> pyridoxine (B6) --> H1 antagonist (doxylamine) --> ondansetron --> phenothiazine (promethazine)
84
management of gastroparesis
dietary --> diabetes management --> avoid meds that induce it --> metoclopramide --> erythromycin --> domperidone/cisapride
85
Al(OH)3
aluminum hydroxide + magnesium hydroxide
neutralizes gastric acidity, increases pH
dyspepsia/GERD
86
CaCO3
calcium carbonate + magnesium hydroxide
neutralizes gastric acidity, increases pH
dyspepsia/GERD
87
Mg(OH)2
magnesium hydroxide
neutralizes gastric acidity, increases pH
dyspepsia/GERD
88
sucralfate
protective paste-like coating in stomach
| SUP, GERD/PUD, stomatitis in chemotherapy, NSAID-induced ulcers
89
cimetidine
H2RA - blocks histamine receptors on parietal cells (basal > food-stimulated secretion)
GERD/PUD, *SUP, gastric hypersecretory states
90
ranitidine
H2RA - blocks histamine receptors on parietal cells (basal > food-stimulated secretion)
GERD/PUD, *SUP, gastric hypersecretory states
91
famotidine
H2RA - blocks histamine receptors on parietal cells (basal > food-stimulated secretion)
GERD/PUD, *SUP, gastric hypersecretory states
92
nizatidine
H2RA - blocks histamine receptors on parietal cells (basal > food-stimulated secretion)
GERD/PUD, *SUP, gastric hypersecretory states
93
omeprazole
PPI - suppresses basal and stimulated acid secretion by inhibiting H/K pump
*PUD +/- bleeding, *gastric hypersecretory states, h. pylori, GERD/PUD (H2RA>), SUP (famotidine >)
94
esomeprazole
PPI - suppresses basal and stimulated acid secretion by inhibiting H/K pump
*PUD +/- bleeding, *gastric hypersecretory states, h. pylori, GERD/PUD (H2RA>), SUP (famotidine >)
95
pantoprazole
PPI - suppresses basal and stimulated acid secretion by inhibiting H/K pump
*PUD +/- bleeding, *gastric hypersecretory states, h. pylori, GERD/PUD (H2RA>), SUP (famotidine >)
96
rabeprazole
PPI - suppresses basal and stimulated acid secretion by inhibiting H/K pump
*PUD +/- bleeding, *gastric hypersecretory states, h. pylori, GERD/PUD (H2RA>), SUP (famotidine >)
97
lansoprazole
PPI - suppresses basal and stimulated acid secretion by inhibiting H/K pump
*PUD +/- bleeding, *gastric hypersecretory states, h. pylori, GERD/PUD (H2RA>), SUP (famotidine >)
98
dexlansoprazole
PPI - suppresses basal and stimulated acid secretion by inhibiting H/K pump
*PUD +/- bleeding, *gastric hypersecretory states, h. pylori, GERD/PUD (H2RA>), SUP (famotidine >)
99
what PPIs are OTC
lansoprazole, esomeprazole, omeprazole
100
misoprostol
analog of prostaglandin E1
| NSAID induced ulcers, PUD, obstetric indications
101
Fe dosing and what drugs decrease its absorption
100-200 1X/DAY --> then BID/TID
| antacids, H2RAs, PPIs
102
historical h. pylori therapy
PPI + clarithromycin + metronidazole or amoxicillin
103
concomitant quad therapy (& how often)
PPI + clarithromycin + amoxicillin + metronidazole or tinidazole
BID
104
bismuth quad therapy
PPI + bismuth + tetracycline + metronidazole or tinidazole
| QID
105
what makes up GI cocktail
viscous lidocaine + liquid antacid +/- antispasmodic
106
what makes up magic mouthwash
viscous lidocaine + liquid antacid + diphenhydramine
| Benadryl + Maalox + lidocaine + simethicone
107
steps to managing GERD in pregnancy
lifestyle --> antacids (AlOH3)--> sucralfate --> H2RA (Ranitidine)--> PPI (anything but omep)
108
wheat dextrin
bulk laxative - speeds up transit
| acute/subacute constipation
109
psyillum
bulk laxative - speeds up transit
| acute/subacute constipation
110
methylcellulose
bulk laxative - speeds up transit
| acute/subacute constipation
111
polycarbophil
bulk laxative - speeds up transit
| acute/subacute constipation
112
docusate
stool softener
| acute/subacute constipation
113
magnesium hydroxide
saline laxative - increases peristaltic action
| acute/subacute constipation
114
Bisacodyl
stimulant laxative - increases motility
| acute/subacute constipation
115
senna
stimulant laxative - increases motility
| acute/subacute constipation
116
castor oil
stimulant laxative - increases motility
| acute/subacute constipation
117
lactulose
hyperosmolar laxative
| mostly hepatic encephalopathy, acute/subacute constipation
118
polyethylene glycol
hyperosmolar laxative
| bowel prep, chronic constipation
119
mineral oil
lubricant laxative
| acute/subacute constipation
120
suppositories
glycerin
| bisacodyl
121
enemas
mineral oil retention
tap water
sodium phosphate
soap suds
122
drugs for CIC
lubiprostone
linactolide
plecanatide
prucalopride
123
lubiprostone
opens Cl- channels on luminal surface of GI epithelium - stimulates Cl- rich intestinal fluid secretion & decreases transit time
CIC, IBS-C, OIC with non-cancer pain
124
linactolide
guanylate cyclase-C receptor agonist - activation of CFTR ion channel - increased secretion of Cl- & bicarb into lumen - increase intraluminal fluid & increased transit time
CIC, IBS-C
125
plecanatide
guanylate cyclase-C receptor agonist - activation of CFTR ion channel - increased secretion of Cl- & bicarb into lumen - increase intraluminal fluid & increased transit time
CIC, IBS-C
126
prucalopride
selective agonist of 5HT4 receptors - stimulates secretions & increases transit time
CIC
127
drugs for OIC
methynaltrexone
naloxegol
naldemedine
128
methylnaltrexone
selective u-opioid receptor antagonist
| OIC with advanced illness (palliative care), OIC with chronic non-cancer pain
129
naloxegol
Pegylated version of naloxone
| OIC with non-cancer pain
130
naldemedine
naltrexone derivative
| OIC with non-CA pain
131
management for children with constipation
1. disimpaction with PEG>enema
| 2. maintenance - dietary, PEG daily
132
management for constipation in pregnancy
1. bulk laxative
| 2. osmotic/saline laxative (PEG = C, lactulose = B)
133
management for constipation for regular outpatient
1. fiber, water, exercise
| 2. simulants, PEG
134
drugs for diarrhea
bismuth subsalicylate
loperamide
diphenoxylate & atropine
135
bismuth subsalicylate
antisecretory, anti-inflammatory, anti-microbial
| mild, non-specific diarrhea; prevention & tx of traveler's diarrhea
136
loperamide
poorly absorbed opioid - decreases peristalsis time and increases transit time
acute diarrhea, IBS-D
137
diphenoxylate & atropine
diphen: inhibits excessive GI motility & GI propulsion, atropine discourages abuse
acute diarrhea, IBS-D
138
management of IBS
1. stress reduction
2. exercise
3. dietary education
4. dietary/supplemental fiber
5. laxatives (PEG & Mg)
6. anti-diarrhea
7. anti-spasmodic (hyoscyamine, dicyclomine)
8. psychotherapy
139
hyoscyamine
antispasmodic for IBS
140
dicyclomine
antispasmodic for IBS
141
drugs for IBS-C
```
lubiprostone
linactolide
plecanatide
tegaserod
tenapanor
SSRI
```
142
tegaserod
antagonist of 5HT4 receptor
| IBS-C in women <65 w/o cardiac history
143
tenapanor
Na+ hydrogen exchanger - increases fluid secretion & acceleration of transit time
IBS-C
144
IBS-D drugs
eluxadoline
alonsetron
rifaximin
TCA
145
eluxadoline
u receptor agonist & delta receptor antagonist
| IBS-D
146
alonsetron
5HT3 receptor antagonist
| IBS-D
147
tolterodine
non-selective muscarinic antagonist - blocks M2 & M3 - blocks M2 & M3 - decreases uninhibited contractions, increases bladder capacity, delays desire to void - decreases IVS
urinary incontinence
148
festoterodine
non-selective muscarinic antagonist - blocks M2 & M3 - blocks M2 & M3 - decreases uninhibited contractions, increases bladder capacity, delays desire to void - decreases IVS
urinary incontinence
149
trospium
non-selective muscarinic antagonist - blocks M2 & M3 - decreases uninhibited contractions, increases bladder capacity, delays desire to void - decreases IVS
urinary incontinence
150
oxybutynin
"primarily" M3 selective antagonist - primarily M3 - decreases uninhibited contractions, increases bladder capacity, delays desire to void - decreases IVS
urinary incontinence
151
solfenacin
"primarily" M3 selective antagonist - primarily M3 - decreases uninhibited contractions, increases bladder capacity, delays desire to void - decreases IVS
urinary incontinence
152
darifenacin
selective M3 antagonist - blocks M2 & M3 - decreases uninhibited contractions, increases bladder capacity, delays desire to void - decreases IVS
urinary incontenence
153
terazosin
"non-selective" post-synaptic a1 antagonist - a1a (relaxes smooth muscle done, relieves OVS) and a1b antagonist (postural hypotension & syncope)
BPH, HTN, medical expulsive therapy for stones
154
doxazosin
"non-selective" post-synaptic a1 antagonist - a1a (relaxes smooth muscle done, relieves OVS) and a1b antagonist (postural hypotension & syncope)
BPH, HTN, medical expulsive therapy for stones
155
alfuzosin
"uroselective" post-synaptic a1 antagonist - just blocks a1 (functionally uroselective)
help pass kidney stones, BPH, bladder outlet obstruction (women)
156
tamsulosin
"uroselective" post-synaptic a1 antagonist - just blocks a1 (functionally uroselective)
help pass kidney stones, BPH, bladder outlet obstruction (women)
157
silodosin
"uroselective" post-synaptic a1 antagonist - just blocks a1 (functionally uroselective)
help pass kidney stones, BPH, bladder outlet obstruction (women)
158
sildenafil
PDE5 inhibitor - potentiates relaxation of smooth muscle for more engorgement
ED, pulmonary arterial HTN
159
tadalafil
PDE5 inhibitor - potentiates relaxation of smooth muscle for more engorgement
ED, pulmonary arterial HTN, BPH
160
vardenafil
PDE5 inhibitor - potentiates relaxation of smooth muscle for more engorgement
ED
161
avanafil
PDE5 inhibitor - potentiates relaxation of smooth muscle for more engorgement
ED
162
filbanserin
agonist at 5HT1, antagonist at 5HT2
| tx of FSIAD in premenopausal women (increases libido, not blood flow)
163
bremelanotide
activates melanocortin receptor subtypes to improve female arousal, sexual desire, orgasm
tx of FSIAD in premenopausal women
164
azathioprine
anti-metabolite - decreases B&T lymphocytes, decreases IL-2 secretion, decreases IG synthesis
transplant, active RA, corticosteroid IBD, psoriatic arthritis
165
mycophenolate
anti-metabolite - decreases B&T cell proliferation
| transplant, GVHD, lupus nephritis/psoriasis/myasthenia gravis
166
cyclosporine
calcineurin-inhibitor - decreases IL-2 production to inhibit activation of resting T cells
transplant, ophthalmic drops for keratoconjunctivitis sicca-associated ocular inflammation, severe/refractory IBD/psoriasis/RA
167
tacrolimus
calcineurin-inhibitor - decreases IL-2 production to inhibit activation of resting T cells (similar to cyclosporine)
transplant, refractory ulcerative colitis, mod-severe atopic dermatitis
168
prednisone for transplant
prodrug to active metabolite prednisolone
| organ transplant
169
sirolimus
suppresses cytokine-driven T-cell proliferation
| prophylaxis for organ rejection
170
belatacept
selective T-cell costimulation blocker
| prophylaxis of RENAL transplant in EBV seropositive pts
171
allopurinol
xanthine oxidase inhibitor
| gout maintenance, prevention of acute uric acid nephropathy during chemo for malignancies
172
febuxostat
xanthine oxidase inhibitor
| gout maintenance, prevention of acute uric acid nephropathy during chemo for malignancies
173
ibuprofen, naproxen for gout
naproxen >>
1st line for acute gout flare
full dose until flare resolves
174
prednisone for gout
for acute gout flare if kidney dz, cirrhosis, HF
175
colchicine
unknown MOA
| 1st line in gout MAINTENANCE, last line in acute gout, familial mediteranean fever, pericarditis
176
probenecid
uricosuric agent - promotes renal clearance of UA (gout diuretic)
prevention of hyperuricemia
*need to have functioning kidneys
177
pegloticase
oxidation of UA --> water-soluble substance that is cleared
| IV of chronic severe symptomatic gout
178
triple therapy for inflammatory arthritis
MTX + leflunomide + hydroxychloroquine
179
biologic therapy for inflammatory arthritis
MTX + TNF-inhibitor (or other biologic)
180
MTX
non-biologic DMARD - inhibits DNA synthesis
tumors, RA, psoriasis/psoriatic arthritis
anti-metabolite for chemotherapy
181
leflunomide
non-biologic DMARD - inhibits DNA synthesis
| RA for pts who get MTX toxicity
182
hydroxychloroquine
non-biologic DMARD - inhibits movement of neutrophils & chemotaxis of eosinophils
RA, SLE, anti-malaria
183
sulfasalazine
non-biologic DMARD- inhibits prostaglandin synthesis
| RA, IBD
184
tofacitinib
JAK inhibitor
| mod-severe RA, psoriatic arthritis, UC
185
baricitinib
JAK inhibitor
| mod-severe RA
186
upadacitinib
JAK inhibitor
| mod-severe RA
187
infliximab
biologic DMARD, TNF-inhibitor; blocks TNF, a proinflammatory cytokine
mod-severe RA, psoriatric arthritis, severe plaque psoriasis, IBD, ankylosing spondyltitis, sJIA
188
etanercept
biologic DMARD, TNF-inhibitor; blocks TNF, a proinflammatory cytokine
mod-severe RA, psoriatric arthritis, severe plaque psoriasis, IBD, ankylosing spondyltitis, sJIA
189
adalimumab
biologic DMARD, TNF-inhibitor; blocks TNF, a proinflammatory cytokine
mod-severe RA, psoriatric arthritis, severe plaque psoriasis, IBD, ankylosing spondyltitis, sJIA
190
certolizumab
biologic DMARD, TNF-inhibitor; blocks TNF, a proinflammatory cytokine
mod-severe RA, psoriatric arthritis, severe plaque psoriasis, IBD, ankylosing spondyltitis, sJIA
191
golimumab
biologic DMARD, TNF-inhibitor; blocks TNF, a proinflammatory cytokine
mod-severe RA, psoriatric arthritis, severe plaque psoriasis, IBD, ankylosing spondyltitis, sJIA
192
abatacept
biologic DMARD, t-cell costimulation blocker
| for RA pts who dont respond to TNF inhibitor
193
rituximab
biologic DMARD, CD20 mab
| for RA pts who dont respond to TNF inhibitor
194
anakinra
biologic DMARD, IL-1 antagonist
| for RA pts who dont respond to TNF inhibitor
195
sarilumab
biologic DMARD, IL-6 antagonist
| for RA pts who dont respond to TNF inhibitor
196
toclizumab
biologic DMARD, IL-6 antagonist
| for RA pts who dont respond to TNF inhibitor
197
apremilast
PDE-4 inhibitor - down regulation of inflammatory cytokines
| psoriatic arthritis, severe plaque psoriasis
198
secukinumab
IL-17 antagonist
| psoriatic arthritis, severe plaque psoriasis
199
ixekizumab
IL-17 antagonist
| psoriatic arthritis, severe plaque psoriasis
200
ustekinumab
IL-12/23 antagonist
| psoriatic arthritis, severe plaque psoriasis, chrons
201
cyclophosphamide
alkylating chemotherapy agent - prevents cell division by cross-linking DNA strands
cancer, nephrotic syndrome, GPA, SLE
sterility, hemorrhagic cystitis
202
cisplatin
alkylating chemotherapy agent - prevents cell division by cross-linking DNA strands
cancer
nephrotoxicity, ototoxicity
203
5-FU
anti-metabolite chemotherapy agent - interferes with DNA synthesis
cancer
stomatitis/mucositis, enterocolits, hyperpigmentation
204
cytarabine
anti-metabolite chemotherapy agent - inhibits DNA synthesis
cancer
cytarabine syndrome, severe cerebellar toxicity
205
doxorubicin
antibiotic chemotherapy agent
cancer
radiation recall, cardiotoxicity
206
bleomycin
antibiotic chemotherapy agent
cancer
striae, rash, acute/chronic insterstitial pneumonitis
207
vinblastine
plant alkaloid chemotherapy agent - disrupts formation of mitotic spindle
cancer
myelosuppression, SIADH, hyperuricemia
208
paclitaxel
plant alkaloid chemotherapy agent - disrupts formation of mitotic spindle
cancer
peripheral neuropathy, hypersensitivity, rhythm abnormalities, myelosuppression, arthralgias
209
aprepitat
substance P/NK receptor antagonist
| - delayed CINV (best when combined with dexamethasone + 5HT3)
210
fosaprepitant
substance P/NK receptor antagonist
| - delayed CINV (best when combined with dexamethasone + 5HT3)
211
rolapitant
substance P/NK receptor antagonist
| - delayed CINV (best when combined with dexamethasone + 5HT3)
212
serotonin antagonists for CINV
inhibits serotonin at 5HT3 receptor in small bowel, vagus nerve, CTZ
for ACUTE CINV
213
dexamethasone for CINV
acute & delayed CINV
214
dronabinol
synthetic THC
| CINV that hasn't responded to other therapies
215
nabilone
synthetic THC
| CINV that hasn't responded to other therapies
216
epoetin alfa
similar to natural EPO
| tx of anemia in cancer pts on chemo
217
darpoetin alfa
kinda similar to EPO
| tx of anemia in cancer pts on chemo
218
peginesatide
synthetic, PEGylated analog of EPO
| anemia in CKD pts, cancer pts on chemo
219
filgastrim
granulocyte-colony stimulating factor
| cancer pts receiving myelosuppressive chemo
220
pegfilgastrim
granulocyte-colony stimulating factor
| cancer pts receiving myelosuppressive chemo
221
sargramostrim
granulocyte-macrophage colony stimulating factor
| cancer pts receiving myelosuppressive chemo
