Chemo Pharm Flashcards Preview

Heme/Lymph > Chemo Pharm > Flashcards

Flashcards in Chemo Pharm Deck (22):
1

cyclophosphamide

alkylating agent
broad application (burkitts, breast, ovarian, non hodgkin) AE: hemorrhagic cystitis, give IV hydration at high dose

2

mechlorethamine

alkylating agent
N
topical for cutaneous T cell lymphoma

3

melphalan

alkylating agent
IV
multiple myeloma (plus dexamethasone)

4

chlorambucil

alkylating agent
oral
chronic lymphoblastic leukemia

5

carmustine

alkylating agent
for glioma
AE: myelosuppression

6

streptozocin

alkylating agent
pancreatic islet cell carcinoma, carcinoid tumors
AE: nausea, renal, hepatotoxicity

7

thiotepa

alkylating agent
AE: coma, seizure
hematological malignancy with transplant pt

8

busulfan

alkylating agent
AE: pulmonary fibrosis, hepatic venocclusive disease
given with anticonvulsant
for CML

9

procarbazine

alkylating agent
resistance when cancer cells express MGMT
AE secondary cancer
part of MOPP for hodgkin
part of PVC for glioma

10

dacarbazine

alkylating agent
for hodgkin
AE: myelosuppession, vomit, nausea

11

bendamustine

alkylating agent
CLL and non hodgkin
AE: myelosuppression and mucositis

12

cisplatin

alkylating agent, platinum analogs
requires chloride diuresis and IV hydration
reverse with aluminum
AE: nephrotoxic, ototoxic, nausea, vomit, neuropathy, anemia, AML
testicular cancer, ovary

13

carboplatin

alkylating agent, platinum analogs
AE: myelosuppression
ovarian, small cell lung

14

oxaliplatin

alkylating agent, platinum analogs
neurotoxic, leukemia, pulmonary fibrosis
for colorectal and gastric cancer

15

methotrexate

antimetabolite
folic acid analog
for breast, head, neck, osteosarcoma, CNS lymphoma, non hodgkin, bladder and choriocarcinoma

16

pemetrexed

antimetabolite
S phase activity
AE Myelosuppression, skin rash, diarrhea fatigue, hand foot syndrome
for mesothelioma, NSCLC
supplement with B12 and folic acid

17

pralatrexate

antimetabolite
AE: myelosuppression, rash, diarrhea
supplement with B12 and folic acid
for periferal T cell lymphoma

18

5FU

animetabolite
for colorectal cancer, breast, stomach, pancreas, esophagus, liver

19

capecitabine

animetabolite
5fu prodrug: metastatic breast, colon cancer,

20

TAS102

animetabolite
colorectal cancer

21

cytarabine

S phase animetabolite
AML and non hodgkin

22

gemcitabine

animetabolite
pancreatic, NSCLC, bladder, ovarian, sarcoma, nonhodgkin