Chemokine Summary Flashcards Preview

HD Exam 1 > Chemokine Summary > Flashcards

Flashcards in Chemokine Summary Deck (24):
1

IFN-gamma: main cell source?

Th1, NK cells, NKT cells

2

IFN-gamma: major functions?

TMMI (T cell mediated macrophage immunity), inhibits Th17

3

IL-1: main cell source?

Monocytes/macrophages, other cells

4

IL-1: major functions?

Pro-inflammatory

5

IL-2: main cell source?

Th1

6

IL-2: major functions?

T cell proliferation, Treg survival

7

IL-4: main cell source?

Th2

8

IL-4: major functions?

AB immunity, inhibits Th17

9

IL-6: main cell source?

Monocytes/macrophages, other cells

10

IL-6: major functions?

Innate immunity, B cell growth, induction Th17

11

IL-8: main cell source?

Monocytes/macrophages, other cells

12

IL-8: major functions?

Pro-inflammatory, major neutrophil chemokine

13

IL-10: main cell source?

DCs, monocytes/macrophages, Th2, Tregs

14

IL-10: major functions?

Suppression of some inflammation pw's

15

IL-12: main cell source?

Monocytes/macrophages, DCs

16

IL-12: major functions?

Induction of Th1

17

IL-21: main cell source?

Th1, Th2, Th17

18

IL-21: major functions?

Proliferation of Th1, Th2, Th17

19

IL-23: main cell source?

Monocytes/macrophages, DCs

20

IL-23: major functions?

Th17 expansion and stablization

21

TNF-alpha: main cell source?

Monocytes/macrophages, DCs

22

TNF-alpha: major functions?

Pro-inflammatory

23

TGF-beta: main cell source?

Many cells

24

TGF-beta: major functions?

Induction of Tregs or Th17