Flashcards in Lecture 1, Overview Deck (23):
What CD marker(s) are granulocytes positive for?
What CD marker(s) are monocytes positive for?
What CD marker(s) are DCs positive for?
What CD marker(s) are all T lymphocytes positive for?
What CD marker(s) are T helper lymphocytes positive for?
What CD marker(s) are T cytotoxic lymphocytes positive for?
What CD marker(s) are B lymphocytes positive for?
What CD marker(s) are natural killer cells positive for?
What proportion of each of the 5 major WBC classes are found in the blood, in order?
1. Neutrophils (40-75%)
2. Lymphocytes (20-50%)
3. Monocytes (2-10%)
4. Eosinophils (1-6%)
5. Basophils (less than 1%)
Blood-born antigens are captured by APCs in the ________ (organ).
Antigens in epithelia and CT are collected in the ________ (area).
Distinguish the different classes of MHC.
Class I is all nucleated cells and is A, B, C
Class II is DP, DQ, DR
Differentiate, generally, bacteria, fungi, and viruses.
Bacteria – microorganisms in the environment. Grow rapidly and compete with our cells for nutrients.
Fungi – organisms like mold and yeast. Invade tissues.
Viruses – proteins and nucleic acid. Take over cells and generate their own genetic instructions.
Antibody generators: Molecules which stimulate production of and bind specifically to an AB and/or elicit an immune response
What generally happens during a humoral response?
ABs are produced by Ig-secreting B cells (plasma cells)
- Directed against cell associated and free floating antigens, i.e., bacteria, proteins, etc
What generally happens during a cell-mediated response?
Killing of cells by cytotoxic T lymphocytes (CTLs) and/or production of cytokines by other T cells
- Directed against infected/defective cells, non-self cells
During a humoral response, what 2 places would you find B cells? (Think I meant ABs)
In extracellular fluids (blood plasma, lymph, mucus, etc.) and *on the surface of B cells.
Difference b/w active and passive immunity?
- In active, you mount your own immune response (natural exposure or artificial injection of antigen).
- In passive, you borrow outside ABs (e.g. mother's during birth, naturally, or giving serum ABs artificially)
4 types of immune disorders?
- Immune deficiency (genetic)
- Cancer (must be immuno-compromised)
- Autoimmune disorders
In the LN, where are the B cells primarily located?
In the LN, where are ABs produced by B cells s/p Ag stimulation?
In the LN, where are the T cells primarily located?