Lecture 1, Overview Flashcards Preview

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Flashcards in Lecture 1, Overview Deck (23):
1

What CD marker(s) are granulocytes positive for?

CD15

2

What CD marker(s) are monocytes positive for?

CD14

3

What CD marker(s) are DCs positive for?

CD11c

4

What CD marker(s) are all T lymphocytes positive for?

CD3

5

What CD marker(s) are T helper lymphocytes positive for?

CD3, *CD4

6

What CD marker(s) are T cytotoxic lymphocytes positive for?

CD3, *CD8

7

What CD marker(s) are B lymphocytes positive for?

CD19

8

What CD marker(s) are natural killer cells positive for?

CD56

9

What proportion of each of the 5 major WBC classes are found in the blood, in order?

1. Neutrophils (40-75%)
2. Lymphocytes (20-50%)
3. Monocytes (2-10%)
4. Eosinophils (1-6%)
5. Basophils (less than 1%)

10

Blood-born antigens are captured by APCs in the ________ (organ).

spleen

11

Antigens in epithelia and CT are collected in the ________ (area).

lymph nodes

12

Distinguish the different classes of MHC.

Class I is all nucleated cells and is A, B, C
- Self
Class II is DP, DQ, DR
- Non-self

13

Differentiate, generally, bacteria, fungi, and viruses.

Bacteria – microorganisms in the environment. Grow rapidly and compete with our cells for nutrients.

Fungi – organisms like mold and yeast. Invade tissues.

Viruses – proteins and nucleic acid. Take over cells and generate their own genetic instructions.

14

Define antigen.

Antibody generators: Molecules which stimulate production of and bind specifically to an AB and/or elicit an immune response

15

What generally happens during a humoral response?

ABs are produced by Ig-secreting B cells (plasma cells)
- Directed against cell associated and free floating antigens, i.e., bacteria, proteins, etc

16

What generally happens during a cell-mediated response?

Killing of cells by cytotoxic T lymphocytes (CTLs) and/or production of cytokines by other T cells
- Directed against infected/defective cells, non-self cells

17

During a humoral response, what 2 places would you find B cells? (Think I meant ABs)

In extracellular fluids (blood plasma, lymph, mucus, etc.) and *on the surface of B cells.

18

Difference b/w active and passive immunity?

- In active, you mount your own immune response (natural exposure or artificial injection of antigen).
- In passive, you borrow outside ABs (e.g. mother's during birth, naturally, or giving serum ABs artificially)

19

4 types of immune disorders?

- Immune deficiency (genetic)
- HIV/AIDS
- Cancer (must be immuno-compromised)
- Autoimmune disorders

20

In the LN, where are the B cells primarily located?

Cortex/follicle

21

In the LN, where are ABs produced by B cells s/p Ag stimulation?

Germinal centers

22

In the LN, where are the T cells primarily located?

Paracortex

23

In the LN, where are most of the macrophages primarily located?

Medulla