Chemotherapy

Question 1

Types of systematic anti cancer therapy

Answer 1

Chemo
Targeted therapy
Anti angiogenic
Immunotherapy
Hormonal

Question 2

How do anti angiogenics treat cancer

Answer 2

Inhibit blood supply to tumour

Question 3

How do immunotherapies treat cancer

Answer 3

Stimulate immune system to target cancer

Question 4

How do hormonal therapies treat cancer

Answer 4

Target hormones driving cancer

Question 5

How does electrochemotherapy increase chemo effects

Answer 5

Current makes cells more permeable

Question 6

What type of cancer treatment is crizotinib

Answer 6

Targeted

Question 7

What type of cancer treatment is bevacizumab

Answer 7

Anti angiogenic

Question 8

What type of cancer treatment is carboplatin

Answer 8

Chemo

Question 9

What type of cancer treatment is tamoxifen

Answer 9

Hormonal

Question 10

What type of cancer treatments are pembrolizumab and atezolizumab

Answer 10

Immunotherapy

Question 11

Which treatment are germ cell cancers often exclusively responsive to

Answer 11

Chemo

Question 12

Curative chemo

Answer 12

Get rid of cancer without other interventions

Question 13

Neo adjuvant chemo

Answer 13

Given prior to surgery/radio to improve pt fitness, downstage cancer, and eradicate micro metastases

Question 14

Adjuvant chemo

Answer 14

Chemo Given after surgery/radio to eradicate micro metastasis

Question 15

Palliative chemo

Answer 15

Given to improve cancer symptoms

Question 16

Administration methods of chemo

Answer 16

Topical
SC
IM
Oral
Intra arterial
Intra cavity
Intra the cal
IV

Question 17

5 types of chemo drugs

Answer 17

Alkylating agents
Platinum agents
Antimetabolites
Topoisomerase inhibitors
Tubulin active agents

Question 18

Alkylating agent MOA

Answer 18

Bind to nucleophilic moieties on all molecules, treats cancer by binding to DNA

Question 19

Alkylating agent drug examples

Answer 19

Cyclophosphamide
Ifosfamide
Busulfan

Question 20

Platinum agent MOA

Answer 20

Develop covalent addicts with DNA with kills cells directly and increases indirect cell death during division

Question 21

Platinum agent drug examples

Answer 21

Carboplatin
Cisplatin
Oxaliplatin

Question 22

Antimetabolite MOA

Answer 22

Incorporated into DNA/RNA and interfere with synthesis

Question 23

Antimetabolite drug examples

Answer 23

Methotrexate
6-mercaptopurine
5-fluorouracil

Question 24

Why are antimetabolites e corporates into DNA and RNA

Answer 24

structural analogues of molecules normally incorporated

Question 25

Topoisomerase inhibitor MOA

Answer 25

Loss of DNA topological state regulation during replication, transcription, and chromatin remodelling

Question 26

2 types of Topoisomerase inhibitor types

Answer 26

Topoisomerase-I inhibitor Topoisomerase-II inhibitor

Question 27

Topoisomerase inhibitor drug examples

Answer 27

Ironotecan T1 inhib Topotecan T1 inhib Doxorubicin T2 inhib Epirubicin T2 inhib

Question 28

2 types of Tubulin active agents

Answer 28

Vinca alkaloids Taxanes

Question 29

Vinca alkaloid Tubulin active agent MOA

Answer 29

prevent microtubule assembly mitotic spindle formation preventing mitosis

Question 30

Vinca alkaloid Tubulin active agent drugs examples

Answer 30

Vinblastine Vincristine

Question 31

Taxane Tubulin active agent MOA

Answer 31

bind to microtubules preventing disassembly

Question 32

Taxane Tubulin active agent drug examples

Answer 32

Paclitaxel Docetaxel

Question 33

Bleomycin MOA

Answer 33

Cytotoxic Antibiotic mixture with Antitumour and antibacterial properties

Question 34

Actinomycin D MOA

Answer 34

Cytotoxic antibiotic which inhibits mRNA synthesis

Question 35

L asparaginase MOA

Answer 35

depletes asparaginine in blood and extracellular space depriving tumour of amino acids

Question 36

Trabectedin MOA

Answer 36

distorts DNA shape interfering with intracellular transcription and DNA repair

Question 37

Cell cycle specific chemotherapy

Answer 37

Agents with major activity in a particular cell cycle phase

Question 38

Cell cycle non specific chemo

Answer 38

Agents with significant activity in multiple cell cycle phases

Question 39

Are cell cycle specific drugs schedule dependent or dose dependent

Answer 39

Schedule dependent Cell cycle non specific are dose dependent

Question 40

Which cell cycle phases does vinblastine have significant effect in

Answer 40

G1 and M

Question 41

Which cell cycle phase do tubulin active agents have significant effects in

Answer 41

M

Question 42

Which cell cycle phase do antimetabolites have significant effects in

Answer 42

S

Question 43

Which cell cycle phase do bleomycin, etoposide, topotecan, and daunorubicin have significant effects in

Answer 43

G2

Question 44

Which drugs are cell cycle non specific

Answer 44

Cyclophosphamide Chlorambucil Cisplatin Actinomycin D

Question 45

Chemo general side effects

Answer 45

Nausea, vomiting Mouth ulcers Metallic taste in mouth Diarrhoea Constipation Fatigue Bleeding and bruising Infection risk Rash, skin and nail changes Liver, cardiac, lung, and renal function changes Neuropathy Tinnitus Early menopause, loss of libido, infertility Blood clot Hair loss Allergic reaction

Question 46

Which drug causes flagellate erythema

Answer 46

Bleomycin

Question 47

What drug causes raspberry urine

Answer 47

Doxorubicin

Question 48

What drug causes pulmonary fibrosis

Answer 48

Bleomycin

Question 49

What drug causes palmar plantar erythrodysesthesia

Answer 49

Capecitabine

Question 50

Which drug causes peri orbital oedema

Answer 50

Imatinib