Chemotherapy

Question 1

What is an example of an anti-folate drug?

Answer 1

Methotrexate

Question 2

What is an example of an alkylating drug?

Answer 2

Cyclophosphamide

Question 3

What drug is an example of a Platinum drug?

Answer 3

cisplatin

Question 4

What is an example of a Taxane drug?

Answer 4

Paclitaxel

Question 5

What is an example of a Vinca drug?

Answer 5

Vin

Question 6

How does methotrexate work (mechanism) and how is it metabolised?

Answer 6

It prevents DNA formation, renal metabolisation

Question 7

How does cyclophosphamide work (mechanism) and how is it metabolised?

Answer 7

Forms bonds between DNA and is metabolised renally

Question 8

Complications of methotrexate

Answer 8

Mucositis and bowel perforation

Question 9

Complications of cyclophosphamide

Answer 9

Haemorrhagic cystitis

Question 10

Complications of Cisplatin

Answer 10

Nephrotoxicity, Neurotoxicity and severe vomiting. Treated by forced diuresis

Question 11

How does Paclitaxel work?

Answer 11

Glues microtubules

Question 12

Side effects of Paclitaxel

Answer 12

Allergy, neutropenia and alopecia

Question 13

How does doxorubicin work?

Answer 13

Free radicals, DNA formation

Question 14

Complications of doxorubicin

Answer 14

cardiotoxicity/cardiomegaly

Question 15

What drug is used for platinum resistance in ovarian cancer?

Answer 15

Topotecan

Question 16

What tests are required as a baseline prior to chemotherapy?

Answer 16

1. FBC
2. U&E
3. LFT
4. ECG