Chemotherapy: Antivirals Flashcards Preview

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Flashcards in Chemotherapy: Antivirals Deck (11):
1

Amantadine

Blocks function of M2 ion channel protein involved in nucleocapsid uncoating of influenza virus
Prophylaxis & treatment of Influenza A infections
Not effective vs Influenza B

2

Oseltamavir

Inhibits neuraminidase (aka sialidase, a glycoprotein enzyme that plays essential role in release of viral progeny from infected cells & assists in mvt of virus particles through upper respiratory tract)

3

Zanamivir

Inhibits neuraminidase (aka sialidase, a glycoprotein enzyme that plays essential role in release of viral progeny from infected cells & assists in mvt of virus particles through upper respiratory tract)

4

Acivlovir

Purine analogue
Activated by viral thymidine kinase -> phosphorylated compound inhibits viral DNA polymerase.
Present in Zovirax creams vs Herpes simplex infections of skin & mucous membranes

5

Ganciclovir

Purine analogue
Activated by viral thymidine kinase -> phosphorylated compound inhibits viral DNA polymerase.
Selective against cytomegalovirus

6

Cidofovir

Nucleoside phosphonate analogue of cytosine
Inhibits DNA polymerase of cytomegalovirus

7

Foscarnet

Organic analogue of pyrophosphate
Inhibits DNA polymerase of cytomegalovirus & herpes virus

8

Nevirapine

Non-nucleoside reverse transcriptase inhibitor
Anti-HIV drug

9

Zidovudine (Azidothymidine, AZT)

Thymidine analogue
Nucleoside reverse transcriptase inhibitor

10

Saquinavir

Inhibitor of HIV protease
(Protease is vital for viral replication within cell & release of mature viral particles from an infected cell)

11

HAART therapy

Combination of nevirapine, zidovudine, saquinavir.
Used during serious manifestations of HIV infections in patients with AIDS.