CHLAMYDIA Flashcards
Chlamydia trachomatis
- obligate intracellular bacteria
- contain DNA and RNA
- lacks muramic acid
A-C - trachoma- leading infectious cause of blindness
D-K - genital, neonatal
L1-L3 - LGV
Transmission Chlamydia trachomatis
sexual
during passage through birth canal
hand to eye contact
Elementary Body
Enfectious
Enters the cell via Endocytosis
Reticulate body
Replication
Reorganizes into elementary body
Inactive
Extracellular
Enters the cells by endocytosis
Infectious
Elementary body
Metabolically active
Intracellular
Seen microscopially
Replicates via binary vision
Reticulate (Initial) Body
Cytoplasmic Inclusions in Chlamydia trachomatis
Halberstaedter-Prowazek Inclusions
C. trachomatis types D-K
MCC of STDs
MEN: nongonococcal urethritis, epididymitis, prostatitis
WOMEN: urethritis,cervicitis, PID
Associates w/ REITER’S SYNDROME : conjuctivitis, urethritis, arthritis
C. trachomatis types D-K
NEONATAL PNEUMONIA
- LATE ONSET - 2-4 weeks
- striking tachypnea, characteristic paroxysmal cough (STACCATO COUGH) , ABSENCE OF FEVER and eosinophilia
C. trachomatis types L1- L3
LYMPHOGRANULOMA VENEREUM
*papule or vesicular which ulcerate leads to SUPPURATIVE INGUINAL LYMPHADENITIS (BUBOES)
(+) FREI TEST - intradermal injection of antigen
Refers to an obsolete skin test for venereal lymphogranuloma that uses antigens prepared from chlamydia grown in the yolk sac of a chick embryo
FREI TEST
Sudden onset pneumonia with malaise, fever, anorexia, sore throat, photophobia and severe headache
Bird exposure (BIRD FANCIER’S DISEASE) - PARROTS, PARAKEETS, MACAWS, COCKATIELS
Psittacosis - Chlamydia psittaci
TREATMENT CHLAMYDIA
STD - Azithromycin
CONJUNCTIVITIS - Erythromycin
LGV - Doxycycline
PSITTACOSIS - Azithromycin
