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NU 607 Pharm Quiz 2 > Cholesterol > Flashcards

Flashcards in Cholesterol Deck (17)
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1

4 groups of patients who should be taking statins

1. those with clinical ASCVD (past stroke, MI) regardless of LDL
2. Those with LDL at or ↑ 190 mg/dL
3. Those with DM (without evidence of clinical ASCVD) with LDL 70-189 mg/dL
4. Those 40-75 y/o without clinical ASCVD or DM with LDL 70-189 mg/dL AND ASCVD risk >7.5%

2

who should be on "high intensity" statin therapy?

groups 1 and 2, group 3 if 10 year ASCVD score > 7.5%

3

who should be on "moderate intensity" statin therapy?

group 3 - start moderate based on risk factors (then go to high if needed)
and group 4

4

who should be on "low intensity" statin therapy?

no one really.

5

lovastatin, pravastatin, simvastatin, fluvastatin, atorvastatin, rosuvastatin (which one is the prototype?)

HMG-CoA Reductase Inhibitors (statins)

6

colestipol, colesevelam, cholestyramine
(which one is the prototype?)

Bile Acid Sequestrants

7

which statins are high intensity statins (2)

atorvastatin & rosuvastatin

8

which statins are moderate intensity statins (6)

atorvastatin & rosuvastatin plus pravastatin, simvastatin, fluvastatin, and lovastatin

9

category D & X drugs

D = ACEs, ARBs, DRIs
X = statins

10

class of antilipidemics used mostly for hypertriglyceridemia?

fibric acid derivatives

11

medication associated with gallstones? it is both an adverse effect & contraindication

gemfibrozil (fibric acid derivative)

12

contraindications are myopathy, gallstones, & liver injury

fibric acid derivatives

13

promotes athersclerotic plaque stability, reduces inflammation, improves endothelial fx, enhances vasodilation & reduces thrombus risk

statins

14

indications include: hypercholesterolemia, primary prevention of hypercholesterolemia, post MI, and DM

statins

15

contraindications include liver disease, viral hepatitis, alcoholic cirrhosis

statins

16

adverse effects include new onset DM, myopathy, rhabdo, hepatotoxicity

statins

17

most common drug that causes rhabdo

rosuvastatin