Cholinergic Antagonists Flashcards

1
Q

What cholinergic antagonists are non-selective antimuscarinics?

A

Atropine, scopolamine, benztropine
Oxybutinin, tolterodine
Ipratropium, tiotropium

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2
Q

What cholinergic antagonists are neuromuscular blockers?

A

Atracurium, rocuronium, succinylcholine

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3
Q

Effects of cholinergic antagonists on the heart?

What receptor is acted on?

A

Increase heart rate

M2 receptors

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4
Q

Effects of cholinergic antagonists on blood vessels?

What receptor is acted on?

A

No effect

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5
Q

Effects of cholinergic antagonists on blood pressure?

What receptor is acted on?

A

Minimal effect on BP

M3 receptors

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6
Q

Effects of cholinergic antagonists on the lungs?

What receptor is acted on?

A

Bronchodilation, decrease secretions (drying)

M3 receptors

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7
Q

Effects of cholinergic antagonists on temperature regulation?
What receptor is acted on?

A

Increase body temperature

M3 receptors

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8
Q

Effects of cholinergic antagonists on the eyes?

What receptor is acted on?

A

Mydriasis, cycloplegia (loss of accommodation), decrease outflow of aqueous humor (increase IOP)
M3 receptors

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9
Q

Effects of cholinergic antagonists on the GI/GU system?

What receptor is acted on?

A

Decrease salivation, block detrusor contraction, decrease GI motility
M3 receptors

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10
Q

Effects of cholinergic antagonists on the CNS?

What receptor is acted on?

A

Sedation, confusion

M1 receptors

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11
Q

Effects of cholinergic antagonists on the NMJ?

What receptor is acted on?

A

Flaccid paralysis

Neuromuscular blockers

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