Cholinergic Drugs and Use

Question 1

What type of drug is Acetylcholine and what is it used for?

Answer 1

Direct-acting cholinergic agonist; Intraocular use during surgery causing miosis

Question 2

What type of drug is Carbachol and what is it used for?

Answer 2

Direct-acting cholinergic agonist; Glaucoma Tx or miosis during surgery or ophthalmic exam

Question 3

What type of drug is Bethanechol and what is it used for?

Answer 3

Direct-acting cholinergic agonist; Tx of urinary retention and heartburn; SE = UTI

Question 4

What type of drug is Cevimeline and what is it used for?

Answer 4

Direct-acting cholinergic agonist; tablet for xerostomia Tx

Question 5

What type of drug is Pilocarpine and what is it used for?

Answer 5

Direct-acting cholinergic agonist; Tx for xerostomia, xerostomia related head/neck cancer, miosis (topical), glaucoma (topical)

Question 6

What type of drug is Edrophonium?

Answer 6

Charged, indirect-acting cholinergic agonist (AchE inhibitor)

Question 7

What type of drug is Pyridostigmine?

Answer 7

Charged, indirect-acting cholinergic agonist (AchE inhibitor)

Question 8

What type of drug is Neostigmine?

Answer 8

Charged, indirect-acting cholinergic agonist (AchE inhibitor)

Question 9

What type of drug is Echothiophate?

Answer 9

Charged, indirect-acting cholinergic agonist (AchE inhibitor)

Question 10

What type of drug is Ambenonium?

Answer 10

Charged, indirect-acting cholinergic agonist (AchE inhibitor)

Question 11

What type of drug are Organophosphates?

Answer 11

Neutral, indirect-acting cholinergic agonist (AchE inhibitor)

Question 12

What type of drug is Physostigmine?

Answer 12

Neutral, indirect-acting cholinergic agonist (AchE inhibitor)

Question 13

What type of drug is Donepezil?

Answer 13

Neutral, indirect-acting cholinergic agonist (AchE inhibitor)

Question 14

What type of drug is Galantamine?

Answer 14

Neutral, indirect-acting cholinergic agonist (AchE inhibitor)

Question 15

What type of drug is Rivastigmine?

Answer 15

Neutral, indirect-acting cholinergic agonist (AchE inhibitor)

Question 16

What type of drug is Tacrine?

Answer 16

Neutral, indirect-acting cholinergic agonist (AchE inhibitor)

Question 17

What is Varenicline used for?

Answer 17

Smoking cessation; partial agonist of nAchR’s

Question 18

What is Scopolamine used for?

Answer 18

Motion sickness

Question 19

What is Oxybutynin used for?

Answer 19

GU disorders

Question 20

What is Dicyclomine used for?

Answer 20

GI disorders

Question 21

What is Hyoxcyamine used for?

Answer 21

GI disorders

Question 22

What is Ipratropium used for?

Answer 22

Respiratory disorders

Question 23

What is Tiotropium used for?

Answer 23

Respiratory disorders

Question 24

What is the combination of Atropine + Pralidoxime used for?

Answer 24

Cholinergic poisoning

Question 25

What is Benztropine used for?

Answer 25

Parkinsons disease (reduce tremors)

Question 26

What is Trihexyphenidyl used for?

Answer 26

Parkinsons disease (reduce tremors)

Question 27

What is Procyclidine used for?

Answer 27

Parkinsons disease (reduce tremors)

Question 28

What is Lomotil used for?

Answer 28

GI disorders (mAchR antagonist for travelers diarrhea)

Question 29

What is Darifenacin used for?

Answer 29

GU disorders

Question 30

What is Solifenacin used for?

Answer 30

GU disorders

Question 31

What is Tolterodine used for?

Answer 31

GU disorders

Question 32

What are the SE of Oxybutynin?

Answer 32

Xerostomia, constipation, dizziness, blurred vision

Question 33

Why would you use Darifenacin, Solifenacine, or Tolterodine over Oxybutynin?

Answer 33

They have less xerostomia and constipation with a longer half-life