Chp 19 and 20 Flashcards

Human evolution and Evolution in medicine (46 cards)

1
Q

Gene tree versus species tree problem

A

Gene tree may not accurately reflect species tree

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2
Q

Gene tree

A

depicts evolutionary relationship of a single gene or multiple genes

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3
Q

H. sapien interbreeding with neanderthal

A

1) occured twice with western and eastern neanderthal populations
2) occurred with only eastern and asian H. sapiens

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4
Q

2 pieces of evidence supporting interbreeding between neanderthals and european/asian humans

A

1) 20-30% of neanderthal DNA when looking at genomes of the entire human population
2) Minimal neanderthal DNA found in African lineages

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5
Q

Sahelanthropus tchadensis

A

Earliest hominin, very strong brow ridge, evidence of bipedal movement, low foramen magnum, no more shredding canines, small brain

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6
Q

Aridipithecus

A

Probable early hominin
Foot morphology shows tree gripping
Pelvis suggests climbing and walking combo

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7
Q

Australopithecus

A

Archaic hominins

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8
Q

Archaic hominins

A

have tool building, better techniques for dating these species

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9
Q

Australopithecus afarensis

A

Lucy
Used Mode 1 tools
Found footprints of two individuals walking side by side

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10
Q

Australopithecus megadont

A

archaic hominins
Big cheek bones
large muscle attachment on skull for large chewing muscles
Larger chewing muscles for eating raw roots and tubers

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11
Q

Homo habilis and Homo rudolfensis

A

Skull features begin to look more like modern humans
prominent brow ridge
small brain

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12
Q

Homo eragaster

A

possibly same species as homo erectus
premodern hominins
larger brain
taller

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13
Q

Homo erectus

A

Mode 2 tools
Fire for cooking and warmth
Body plan very similar to modern hominins

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14
Q

Homo heidelbergensis

A

evolved from erectus or eragaster
Gave rise to modern humans
Mode 3 tools
Group hunting

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15
Q

When did homo heidelbergensis split?

A

600k years ago

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16
Q

Homo floresiensis

A

Small brain
Very short due to island life
Large flat feet
hunted pygmy elephants

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17
Q

Homo naledi

A

Found in rising star cave
small brain like australopithecus
Hand and feed like Homo genus
Cranial structure like homo erectus and homo habilis

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18
Q

Which species shows first evidence of use of a burial chamber?

A

Homo naledi

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19
Q

Homo neanderthalensis

A

bigger, stronger, heavier than homo sapiens
Strong brow ridge
Social
buried dead
fire
probably speech
Hunted large game
South/western Europe and some of west Asia

20
Q

When did homo denisovan split?

A

200k years ago

21
Q

Homo luzonesis

A

found in the philippines, very minimal info

22
Q

Homo sapiens

A

Larger, rounded brains
Smaller teeth
pronounced chin
smaller brow ridge

23
Q

When did homo sapiens leave Africa

A

~60k years ago

24
Q

When did denisovans and neanderthals stop existing with H. sapiens

A

30k years ago

25
Upper paleolithic lifestyle
better tools hunting language advanced culture/behavior bone and ivory tools music burial ceremonies
26
Evidence for the out of africa hypothesis
1) genetic evidence - those are African descent have the most genetic variation in mtDNA and Y chromosome DNA 2) technology spread multiple times 3) Gradual spread of H. sapiens across the globe
27
Multiregional hypothesis
Homo erectus originally left Africa and evolved into the other species, which experienced gene flow and all converged to H. sapiens
28
Germ theory of disease
1) pathogen ID 2) Antiseptic surgery 3) Antibiotic 4) Need for sanitation
29
Four levels to the question, why we get sick?
1) Proximate - immediate mechanism, how disease works 2) Developmental - how pathology came about often organism lifetime 3) Evolutionary - How natural selection and other evolutionary processes leave body vulnerable to disease 4) Phylogenetic - look at evolutionary history and close relative to see how an organism is vulnerable
30
proximate level to why we get sick?
immediate mechanism, how disease works
31
Developmental level to why we get sick?
how pathology came about often organism lifetime
32
Evolutionary level to why we get sick?
How natural selection and other evolutionary processes leave body vulnerable to disease
33
Phylogenetic level to why we get sick?
look at evolutionary history and close relative to see how an organism is vulnerable
34
Clinical based treatment includes these two levels to the question, why we get sick?
Proximate and developmental
35
Preventative based treatment includes these two levels to the question, why we get sick?
Evolutionary and phylogenetic
36
6 evolutionary explanations for why we get sick
1) The red queen, humans are locked in arms races with their pathogens which evolve more rapidly 2) Natural selection has not caught up with the rapid changes in the environment 3) Laws of physics and nature of Biology impose trade-offs on what an organism can do 4) NS lacks foresight, stuck in relics of the past 5) NS favors reproductive success at expense of vulnerability of disease 6) Some defenses may be unpleasant but are beneficial - reproductive health over well being
37
Costs of a fever
feeling crappy metabolism Super high fevers are dangerous
38
What is the smoke alarm analogy for fevers?
false negatives are more costly, better to think there is a fire every time you cook rather than miss a fire
39
3 predictions behind smoke alarm predictions
1) cost of a fever is less than getting sick, better to have one even if unnecessary 2) Intervention is okay in some cases, antibiotics only if necessary 3) Shouldn't always stop fever
40
Levy's guidelines to reduce antibiotic resistance
1) avoid bad bacteria (don't eat raw food) 2) Antibacterial soaps and cleaners ONLY to prevent infection 3) Don't use unneeded antibiotics 4) complete antibiotic course 5) Avoid spreading infections by using proper hygiene 6) Use drugs that target a narrow range of bacteria 7) Isolate patients infected with resistant bacteria
41
Three hypotheses of virulence theory
1) coincidental evolution hypothesis 2) the short-sighted evolution hypothesis 3) The tradeoff hypothesis
42
Coincidental evolution hypothesis
just happens to cause issues when inside you, typically benign in the environment
43
Short-sighted evolution hypothesis
Evolves within adaptations that are beneficial to the pathogen’s prevalance in the host, but may harm its reproduction (polio virus does really well in one reaches neuron, but harms host and prevents spread)
44
The tradeoff hypothesis
Natural selection should favor pathogens that strike an optimal balance between the costs and benefits of harming their hosts (cordyceps fungus has weevil walk to optimal location to spread spores)
45
Why do we die?
Disposable soman hypothesis
46
Disposable soman hypothesis
It is more beneficial to invest in reproduction over repair because sooner or later something will get you