Chris Bailey Dopamine Receptors

Question 1

Drugs of abuse increase synaptic dopamine concentrations in the mesolimbic systems

Answer 1

Di Chiara and imperato 1988

Question 2

PET scans comparing drug addicts to controls on the use of methylphenidate, drug addicts show less fluoresce meaning less D2 receptors

Answer 2

Volkow et al 1997

Question 3

Non addicts - those with fewer D2 receptors liked the effects of methylphenidate more

Answer 3

Volkow 1999

Question 4

Polymorphisms in the D2 receptor gene affect expression, splicing and neuronal activity during working memory

Answer 4

Zhang et al 2007

Question 5

Rats with low D2 receptors in their nucleus accumbens have been shown to be more impulsive and administer more cocaine than those with high density

Answer 5

Dalley 2007

Question 6

Dominant subjects had less drug seeking behaviour and more D2 receptors than the submissive subjects –> compared in different environments (no toys, isolation) rewarding environments increased D2 levels and decreased cocaine self administration

Answer 6

Nadar et al 2008

Question 7

PET scan in monkeys looked at chronic cocaine use, compared D2 receptor density at 6 and 12 months and the density decreased

Answer 7

Nadar et al 2006