Saraha Bailey Neurogensis Flashcards
Knocking out the 5HT1A receptor in mice resulted in them being insensitive to SSRI effects and having reduced neurogenesis
Santarelli 2003
Elevation of glucocorticoids can trigger depression and impair adult hippocampal neurogenesis
Cameron and Gould 1994
Exercise especially running can increase AHN and is recommended by what?
NICE
Castren et al 2007
- val/met polymorphism in BDNF in post-mortem studies on depressions patients
- had a smaller hippocampal volume
- polymorphism also in anxiety, OCD &a eating disorders which are successfully treated with antidepressants
- antidepressants restore BDNF levels in brain
- stress reduces BDNF levels which can be prevented using antidepressants
Mice with the BDNF val/met substitution were resistant to fluoxetine- does this contribute to the 40-60% treatment failure of 1st line antidepressants
Chen et al 2006
Neurogenic theory of depression suggests that impaired AHN triggers depression and restoration of AHN leads to recovery
Jacobs et al 2000
Depressed patients have been shown to have smaller hippocampi
Kempton et al 2011
Adult born hippocampal neurones are required for efficient pattern separation and cognitive function in rodents, these are cognitive functions that may be impaired in depressed patients
Sahar and hen 2007
Antidepressant use increases adult hippocampal neurogensis
Miller & hen 2015
Current treatment of depression including ECT (a) fluoxetine (b) and lithium (c) were shown to boost AHN
a- madsen et al 2000
b- malberg et al
c- Chen 2000
Review of studies involving ablation of AHN in mice found no effect on baseline anxiety
Petrik et al 2012
5 key points in Miller and hen 2015 study
1) AHN is altered in depression/anxiety
2) impaired AHN is sufficient to induce depression/anxiety
3) treatments of depression/anxiety alter AHN
4) AHN is required for antidepressant efficacy
5) increased AHN is sufficient to treat depression/anxiety
