Chronic Inflammation

Question 1

What are the cell types involved in chronic inflammation ?

Answer 1

• Lymphocytes
• Macrophages
• Plasma Cells
• Fibroblasts

Question 2

List the major causes of Chronic Inflammation.

Answer 2

• Arising from acute inflammation
   -Large volume of damage
   -Inability to remove debris
   -Fails to resolve
• Arising as a primary lesion
   -No acute phase
   -Can be a result of :
  - Autoimmunal disorder
  - Material resistant to cellular digestion
  - Exogenous substances eg. Sutures, glass
  - Endogenous subtances eg. Keratin, Hair, necrotic tissue

Question 3

Describe the effects of Chronic Inflammation.

Answer 3

o Scarring and fibrosis

o Granuloma formation

Question 4

List the factors involved in promoting healing and repair.

Answer 4

o	Cleanliness
o	Apposition of edges
o	Sound nutrition
o	Metabolic stability and normality
o	Normal inflammatory and coagulation mechanisms

Question 5

List the factors that impair healing and repair.

Answer 5

o Dirty gaping wound, large haematoma
o Poorly nourished, lack of vitamins C and A
o Abnormal CHO metabolism, diabetes, corticosteroid therapy
o Inhibition of angiogenesis

Question 6

What is the role of angiogenesis in healing and repair ?

Answer 6

This is the formation of new blood vessels.

This simply enables the blood supply to enter the damaged tissue.