Chronic liver disease Flashcards Preview

Gastrointestinal > Chronic liver disease > Flashcards

Flashcards in Chronic liver disease Deck (9):
1

What is chronic liver disease?

When it lasts for more than 6 months and can still present acutely.
End stage is almost always cirrhosis

2

How is the progression of Chronic liver disease?

Recurrent Inflammation -> fibrosis -> repair and regeneration

3

When does a patient with CLD present with symptoms of liver failure?

When the cirrhosis becomes decompensated

4

How are stellate cells activated in hepatic fibrosis?

Stimulation neighboring cell types - sinusoidal endothelium, Kupffer cells, hepatocytes, platelets, and leukocytes
Kupffer cell - releases cytokines (TGF, RoS, MMP-9) which stimulate collagen synthesis

5

What are the cytokines released by KUpffer cells which stimulate collagen synthesis in hepatic stellate cells?

TGF, MMP-9, RoS

6

How is simple steatosis in NAFLD diagnosed and managed?

Diagnosis - Ultra sound
Management - Weight loss and exercise
Risks - increased cardio-vascular risks

7

What is the pathogenesis of NAFLD?

1st hit - Excess fat accumulation
2nd hit - Intrahepatic oxidative stress
Lipid peroxidation
TNF-alpha, cytokine cascade (pro-inflammatory)

8

What is the histopathology of NAFLD?

Maladaptive response to oxygen stress

9

What are the risks, diagnosis and management of Non-alcoholic steato-hepatitis?

Risks - Progression to Cirrhosis
Diagnosis- On presentation with liver biopsy
Management - Weight loss and exercise, experimental treatments