Flashcards in Chronic Pulmonary Infection Deck (24)
what are the risk factors for the development of CPI?
abnormal innate host defence
what are the types of immune deficiency that are risk factors for the development of CPI?
why is IgA deficiency associated with recurrent infections?
because it sits in the bronchial mucosa
what are the immunosuppressants that are risk factors for the development of CPI?
what are the types of abnormal that are risk factors for the development of CPI?
damaged bronchial mucosa
what are the types of repeated insult that are risk factors for the development of CPI?
what causes IgA deficiency?
hypogammaglobulinaemia : its a rare condition and means that there is an increased risk of acute and chronic infection
what is the commonest cause of immunodeficiency?
CVID - you get recurrent chest infections
what are the types of immunodeficiency?
specific polysaccharide antibody deficiency (SPAD)
why do we need antibodies that are sensitive to the polysaccharide coat - the problem in SPAD
many pathogens have a polysaccharide coat
where are antibodies made/
what is the commonest pathogen
why may people have hyposplenism?
results from sickle cell disease as they get infarcts in their spleen
what happens in immune paresis
the immune system was fine but is now paralysed in some way
what problems give you immune paresis?
myeloma, lymphoma, metastatic malignancy
what happens in myeloma?
you get lots of one type of antibody
which therapies are immunosuppressive ?
what monoclonal antibodies are there
infliximab - TNF alpha
Rituximab : CD20
what can cause damaged bronchial mucosa?
recent pneumonia or viral infection - because mucosa is damaged
what can cause abnormal cilia ?
what causes abnormal secretions
CF- mucus is very thick
what causes recurrent aspiration indult?
what causes indwelling material ?
NG tube in the wrong place
inhaled foreign body