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Respiratory: Chronic Infections > Chronic Pulmonary Infection > Flashcards

Flashcards in Chronic Pulmonary Infection Deck (24)
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1

what are the risk factors for the development of CPI?

immunodeficiency

immunosuppression

abnormal innate host defence

repeated insult

2

what are the types of immune deficiency that are risk factors for the development of CPI?

congenital

acquired

IgA deficiency

3

why is IgA deficiency associated with recurrent infections?

because it sits in the bronchial mucosa

4

what are the immunosuppressants that are risk factors for the development of CPI?

drugs

malignancy

5

what are the types of abnormal that are risk factors for the development of CPI?

damaged bronchial mucosa

abnormal cilia

abnormal secretions

6

what are the types of repeated insult that are risk factors for the development of CPI?

aspiration

indwelling material

7

what causes IgA deficiency?

hypogammaglobulinaemia : its a rare condition and means that there is an increased risk of acute and chronic infection

8

what is the commonest cause of immunodeficiency?

CVID - you get recurrent chest infections

9

what are the types of immunodeficiency?

IgA deficiency

CVID

specific polysaccharide antibody deficiency (SPAD)

hyposplenism

immune paresis

HIV

10

why do we need antibodies that are sensitive to the polysaccharide coat - the problem in SPAD

many pathogens have a polysaccharide coat

11

where are antibodies made/

spleen

12

what is the commonest pathogen

pneumococcus

13

why may people have hyposplenism?

results from sickle cell disease as they get infarcts in their spleen

14

what happens in immune paresis

the immune system was fine but is now paralysed in some way

15

what problems give you immune paresis?

myeloma, lymphoma, metastatic malignancy

16

what happens in myeloma?

you get lots of one type of antibody

17

which therapies are immunosuppressive ?

steroids

azathioprine

methotrexate

cyclophosphamide

monoclonal antibodies

chemotherapy

18

what monoclonal antibodies are there

infliximab - TNF alpha

Rituximab : CD20

leflunomide

19

what can cause damaged bronchial mucosa?

smoking

recent pneumonia or viral infection - because mucosa is damaged

malignancy

20

what can cause abnormal cilia ?

kartagener's syndrome

youngs' syndrome

21

what causes abnormal secretions

CF- mucus is very thick
channelopathies

22

what causes recurrent aspiration indult?

NG feeding

poor swallowing

pharyngeal pouch

23

what causes indwelling material ?

NG tube in the wrong place

chest drain

inhaled foreign body

24

what are the forms of chronic infection

intrapulmonary abscess

empyema

chronic bronchial sepsis

CF

bronchiectasis