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Chunk Flashcards

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1
Q

Tricyclic antidepressants: Tertiary amines

A 
Amitriptyline
Clomipramine
Doxepin
imipramine
trimipramine
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2
Q

Tricyclic antidepressants: Secondary amines

A

nortriptyline
desipramine
protriptyline

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3
Q

SSRIs

A 
Fluoxetine
Fluvoxamine
Paroxetine
Sertraline
Citalopram
Escitalopram
Vilazodone
Vortioxetine
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4
Q

SSRIs first line treatment for what disorders?

A 
Depression
OCD
Panic disorder
Social phobia
PTSD
Premenstrual DD
GAD
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5
Q

SSRI with longest half life?

A

Fluoxetine (1-3 days)

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6
Q

SSRI with shortest half life?

A

Fluvoxamine (15 H)

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7
Q

SSRIs that DO NOT interact with CYP 450?

A

Citalopram

Escilatopram

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8
Q

Most activating SSRIs?

A

Fluoxetine

Sertraline

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9
Q

Most sedating SSRIs?

A

Paroxetine (+weight gain)

Fluvoxamine

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10
Q

Serotonin Syndrome clinical triad?

A

Cognitive effects
Neuromuscular dysfunction
Autonomic dysfunction

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11
Q

Serotonin syndrome drugs

A 
Cocaine
Dextromethorphan
Meperidine
SSRI
TCA
Trazodone
Venlafaxine
L dopamine
L tryptophan
MAOIs
Amphetamines
Lithium
MDMA
Triptans
Buspirone
LSD
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12
Q

SNRIs

A 
Main:
Duloxetine
Venlafaxine
Desvenlafaxine
Other:
Levomilnacipran
Milnacipran
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13
Q

NDRIs

A

Buproprion

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14
Q

Serotonin Receptor Antagonists

A

Trazodone
Mirtazapine
Nefazodone

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15
Q

MAOIs: non selective

A

Phenelzine

Tranylcypromine

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16
Q

MAOIs: MAO-B inhibitors

A

Selegiline Transdermal System

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17
Q

CYP 1A2 inhibitor

A

Fluvoxamine

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18
Q

CYP 2D6 inhibitors

A

Bupropion
Fluoxetine
Paroxetine

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19
Q

CYP 3A4 inhibitor

A

Nefazodone

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20
Q

Antidepressants that cause somnolence?

A

Mirtazapine
Paroxetine
Trazodone

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21
Q

Antidepressants that cause increase in energy?

A

Bupropion
SNRI
Fluoxetine
Sertraline

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22
Q

Antidepressants that can cause reduction in pain?

A

Duloxetine (Fibromyalgia/Neuropathic)
Venlafaxine (Fibromyalgia/Neuropathic)
Amitriptyline (Diabetic neuro)
Imipramine (Diabetic Neuro)

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23
Q

Augmentation to depression therapy?

A

Lithium
Thyroid stimulants
Atypical antipsychotis

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24
Q

Bipolar: Anticonvulsants?

A

Divalproex/Valproic acid
Carbamazepine
Lamotrigine
Topiramate

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25
Bipolar: Benzodiazepines?
Lorazepam | Diazepam
26
Drugs causing parkinson's symptoms?
``` prochlorperazine chlorpromazine trifluoperazine thioridazine haloperidol metoclopramide ```
27
Parkinsons: Dopamine agonists?
Non Selective: Bromocriptine Non Ergot: Ropinirole Pramipexole D2 Selective: Apomorphine
28
Parkinsons: Dopamine analogs?
levodopa/Carbidopa
29
Parkinsons: Muscarinic antagonists "anticholinergic"?
Benztropine | Trihexyphenidyl
30
Parkinsons: NDMA receptor inhibitor?
Amantadine
31
Parkinsons: Decreased catabolism: COMT inhibitors?
Tolcapone Entacapone Carbidopa/Levodopa/Entacapone
32
Parkinsons: Decreased Catabolism: MAOIs
Selegiline | Rasagiline
33
Drugs used to treat a broad range of seizure types?
``` Carbamazepine Felbamate Lamotrigine Levetiracetam Oxcarbazepine Phenytoin Topiramate Valproate Zonisamide ```
34
Drugs used primarily for focal onset seizures?
``` Carbamazepine Gabapentin Lacosamide Oxcarbazepine Phenobarbital Phenytoin Pregabalin Tiagabine Vigabatrin Valproate ```
35
Absence seizure medications?
Ethosuximide | Valproate (Alt)
36
Phenytoin non dose related adverse effects?
Sexual Dysfunction Hirsutism Gingival hyperplasia Coarsening of facial features
37
Phenytoin dose related adverse effects?
Nystagmus Blurred/double vision Thick tongue Dizziness
38
Prolonged febrile seizures may be treated with?
phenobarbital | diazepam
39
Status epilepticus: Emergency medications?
Lorazepam Diazepam Midazolam
40
Status Epilepticus: Urgent medications?
Fosphenytoin Phenytoin Phenobarbital
41
Status epilepticus: Refractory medications?
Pentobarbital Propofol Midazolam
42
Drugs that decrease effectiveness of Oral contraceptives, patch, ring, implant?
``` Carbamazepine Felbamate lamotrigine Oxcarbazepine Phenobarbital Phenytoin Primidone Topiramate ```
43
High incidence of sexual dysfunction (Seizure meds)
``` Carbamazepine phenobarbital phenytoin pregabalin topiramate zonisamide ```
44
Improved sexual functioning (Seizure meds)
Lamotrigine | Oxcarbazepine
45
Decreased bone health (Seizure meds)
``` Carbamazepine Clonazepam Phenobarbital Phenytoin Valproic acid ```
46
Seizure meds with highest incidence of depression/suicide?
``` levetiracetam phenobarbital primidone tigabine topiramate vigabatrin ```
47
Typical (First generation) Antipsychotics: Low potency
Chlorpromazine | Thioridazine
48
Atypical (Second generation) antipsychotics
``` Aripiprazole Asenapine Clozapine Illoperidone Lurasidone Olanzapine Paliperidone Quetiapine Risperidone Ziprasidone ```
49
Typical (First Generation) antipsychotics: High potency
Trifluoperazine Fluphenazine Haloperidol
50
Antipsychotics for acute agitation and psychosis: Orally disintegrating tablets?
Risperidone | Olanzapine
51
Antipsychotics for acute agitation and psychosis: Parenteral formulation
Ziprasidone | Olanzapine
52
Antipsychotics for acute agitation and psychosis: Rapid tranquilization?
``` Chlorpromazine Fluphenazine Haloperidol (Preferred) Ziprasidone (Preferred) Olanzapine (Preferred) ```
53
Antipsychotics for acute agitation and psychosis: non compliant patients?
Haloperidol Decanoate Fluphenazine Decanoate Long acting risperidone (CONSTA) Paliperidone
54
Short acting barbiturates (Used for anesthesia)
Methohexital (C4) Pentobarbital Secobarbital Amobarbital
55
Short acting BZDs
Midazolam Oxazepam Triazolam
56
Intermediate acting BZDs
alprazolam Estazolam Lorazepam Temazepam
57
Long acting BZD
``` Chlordiazepoxide Clonazepam Diazepam Flurazepam Quazepam ```
58
Clinical Use for BZD?
``` Anxiolytic (Sedative) Hypnotic(High Doses) Muscle Relaxation Anticonvulsant Anesthesia/amnesia ```
59
BZD indicated for alcohol withdrawal?
Oxazepam Lorazepam Chlordiazepoxide DIazepam
60
BZD indicated for insomnia?
``` Triazolam (Induction) Estazolam (Maintenance) Temazepam (Maintain) Flurazepam (Induce/maintain) Quazepam (Induce/maintain) ```
61
BZDs that are substrates of CYP3A4?
Alprazolam Clonazepam Temazepam
62
Safest BZD for Geriatric populations?
Lorazepam Oxazepam Temazepam
63
Sedating antidepressants?
Doxepin Mirtazepine Trazodone
64
Insomnia: Sleep onset non BZD
Eszopiclone Zaleplon Zolpidem Ramelteon
65
Insomnia: Sleep maintenance non BZD?
Eszopiclone | Zolpidem CR
66
Insomnia: Chronic non BZD?
Eszopiclone | Ramelteon
67
Stimulants for ADHD
Amphetamines Dextroamphetamine Methylphenidate/Dexmethylphenidate Lisdexamfetamine
68
Non stimulants for ADHD
Atomoxetine Clonidine XR Guanfacine XR
69
TCAs for ADHD?
Imipramine | Desipramine
70
Obesity: Reduction of fat absorption?
Orlistat
71
Obesity: Reduce appetite: Sympathomimetics?
``` Benzphetamine Diethylpropion Phentermine Phendimetrazine Bupropion ```
72
Obesity: Reduce appetite: Serotonergic?
Lorcaserin | Topiramate
73
Obesity: Reduce appetite: Antidiabetic?
Liraglutide | Metformin
74
Obesity: Combo?
Phentermine-topiramate | Bupropion-naltrexone
75
Pre-anesthetic medications?
``` Antacids anticholinergics antiemetics antihistamines BZD Opioids ```
76
General anesthetics: Inhales
``` Desflurane Halothane Isoflurane Nitrous Oxide Sevoflurane ```
77
General anesthetics: IV
``` Barbituates BZD Dexmedetomidine Etomidate Ketamine Opioids Propofol ```
78
Neuromuscular blockers
``` Cisatracurium Pancuronium Rocuronium Vercuronium Succinylcholine ```
79
Local Anesthetics | Esters
``` Benzocaine Chloroprocaine Cocaine Procaine Tetracaine ```
80
Local anesthetics | Amides
``` Articaine Bupivacaine Dibucaine Levobupivacaine Lidocaine Mepivacaine Prilocaine Ropivacaine ```
81
Topical local anesthetics
Lidocaine 5% Patch Lidocaine Prilocaine TAC Solution LET Gel
82
Geriatric considerations for seizures? Carbamazepine? Phenytoin? Valproic Acid? Diazepam? Lamotrigine?
``` Carbamazepine decreased clearance Phenytoin decreased protein binding in renal failure Valproic acid decreased protein binding Diazepam increased half life Lamotrigine decreased clearance ```

Pharmacology (2 decks)

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