CIS 3 Flashcards
(33 cards)
Which of the following is most used to diagnose primary coagulopathies (embolism)?
NOT PTT and PT: they will measure clotting time.
for bleeding disorders, what do we measur/
PT
aPTT
CBC
platelet function testing
For thrombotic diosders, what do we measure?
Genetic testing
APCR
Endogenous anticoagulant levels
should we ever pick bleeding time as a test to measure?
no
Venous thrombosis ( ___ thrombus)
charactistic?
red
swollen and painful, warm
o Name the artery most likely to be empolized by a red thrombus
pulmonary A.
if limb is VERY pain and pulseless, what should we assume?
arterial thrombosis (white thrombosis?
Characteristics of arterial thrombosis?
Cyanotic, because O2 is not arriving
Platelet rich, occur in high shear stress
How can we test if someone has a problem with fibrinogen?
• Thrombin
Thrombin time: adding thrombin to a blood sample will bypass all other clotting factors and force a clot, unless ____ is deficient
fibrinogen
Most likely cause massive bleeding
fluid loss => hypovolemic shock
What would we most likely see in septic shock?
low blood pressure and increased HR to compensate
bc one of the first things to happen is vasodilationd d/t inflammation => lower BP. Endthelial spaces widen and fluid leaks out=> further lower BP
Physical exams of septic shock would show:
soft tissue edema wet lungs leukocytosis (inflammatory response) hyPOtension necotic toes
Shock occurs when ________________. Injury is only reversible in the beginning. 3 types
not enough CO or circulating blood volume to supply tissues, causing hypoxia
Cardiogenic shock: damage to ________ causes low CO
myocardial pump
Hypovolemic shock:_______ causes low CO
low blood volume (V/D/fkuid loss, burns)
Septic shock is d/t _____
infection that causes vasodilation, leakage and decreased BP
Ex. ruptured appy
Thus, thrombin has a role in: primary hemostasis, secondary and regulation (anticoagulation).
what are they
induced platelt action and aggregation
binds to thrombomodulin => + protein C => anticoagulation
Diagnose endocarditis
use a stethoscope (hear whooshing, murmur
• Endocarditis is a primary process occurring in the <3: that manifests as
splinter cells
painless janeway lesions
Painful osler nodes
roth spots
What initial intervention is the best for white thrombo-embolism?
• NSAIDS (CHEW ASPIRIN);! they DIRECTLY
o Which of the following factors would ensure that areas of the heart are not prone to ischemia?
<3 has collateral pathways: allows bypass of areas where thrombus would form and cause infarction
fibrinOID necrosis, not
finbrinous
Marfans may have with TGF-B is _____, with IL-10 is ________
TGF-B is antiinflammatory
IL-10: PRO inflammatory
