CIS things Flashcards
(17 cards)
What is the function of C1 inhibitors?
what happens if there’s no C1 inhibitor
binds to and inactivates C1r and C1s proteases in the classical pathway of complement
MASP1 and MASP 2 in the lectin pathway
overproduction of c4a, c3a, c5a so high inflammatory components which lead to. the increased capillary permeability, fluid and edema
What is Paroxysmal Nocturnal Hemoglobinuria?
What is the deficiency?
failure to regulate the formation of the MAC
glycosylphosphatidylinositol (lipd tail that anchors stuff to cell membrane)
so proteins are deficient on the surfaces of the cells
What 2 complement molecules are anchored by glycosylphosphatidylinositol?
DAF (regulates c3 converts)
CD59, which restricts the formation of the MAC
CD59 deficiency causes what?
intravascular hemolysis that characterizes PNH
what Ig passes the placental barrier?
IgG
What allows IgG to travel across maternal barrier?
FcRN- mediated transport
what age do infants develop the ability to synthesize antibodies?
fetus starts making in utero, IgM at second trimester
6 month it needs to rely on its own because mother’s disappear
What was the origin of immunotolerance?
giving large doses of pneumococcal polysaccharides didn’t work compared to low and intermediate doses
What did repeated large doses do to the pt?
made them immunotolerant
Polysaccharide antigens are what for T cells?
T cell independence antigens
IgM response fades quickly due to short half-life of IgM
Why are conjugate vaccines using protein carriers?
because IgM by itself has a short half life but putting them with protein carriers allows for it to go from T cell independent to T cell dependent, which would favor IGG
T cell independent antigens are almost exclusively what?
polysaccharides
Which B cell responds to TI antigens?
MZ and B1
create short lived plasma cells that produce IgM
What are the 3 types of TI antigens?
polysaccharides
glycolipids
nucleic acids
What do polysaccharides activate in the complement system?
alternative by generating C3b which is processed to C3d to be recognized by CR2 on b cells
What do you link a capsular saccharide to that allows for immunization of that capsule?
tetanus toxoid or diphtheria toxoid
prophylactic measures should physician recommend to prolong life expectancy of a child?
antibiotics (penicillin)
prophylactic administration of gamma globulin every 4-6 weeks
antibiotics at earliest sign of respiratory infection
