Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

IMMUNOSERO 2 > CIULLA NOTES > Flashcards

CIULLA NOTES Flashcards

1
Q

Antinuclear antibodies associated with

A
  • SLE
  • MCTD
  • RA
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Techniques used to detect ANA

A
  • Agglutination
  • Indirect Immunofluorescence
  • Enzyme Immunoassay
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Diffuse or Homogenous

A

Anti-DNA antibody and Histones

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Peripheral Indirect IF results

A

Anti-DNA antibody and anti-lamins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Speckled pattern

A

nuclear ribonucleoprotein (RNP)
anti-smith

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Nucleolar

A

stains two or three large fluorescent areas
anti-RNP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Stains as a discrete speckled pattern due to anti-
centromere antibody

A

Centromere

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q
  • Anti-antibody
  • IgM
  • binds to FC portion of abnormal IgG
  • detected by latex agglutination
A

Rheumatoid factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q
  • Proteins that reversibly precipitate at 4°C
  • autoimmune
  • vasculitis
  • glomerulonephritis
    SLE
    RA
    Sjogren syndrome
A

Cryoglobulins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Autoantibody: Centromere
Disease:

A

CREST (calcinosis, Raynaud syndrome, esophageal
hypomotility sclerodactyly, and telangectasia) syndrome
dsDNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Autoantibody: dsDNA
Disease:

A
  • SLE
  • low titers RA and Sjogren Syndrome
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Autoantibody: Histone
Disease:

A

Drug-induced SLE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Autoantibody: Nuclear RNP
Disease:

A
  • SLE
  • Mixec Connective tissue disease
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Autoantibody: Scl-70
Disease:

A

Scleroderma (systemic sclerosis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Autoantibody: Sjogren syndrome A (SSA {Ro})
Disease:

A

Sjogren Syndrome
SlE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Autoantibody: Sjogren syndrome B (SSB [LA])
Disease:

A

Sjogren syndrome
SLE

17
Q

Autoantibody: Sm
Disease:

A

SLE (high specificity) but low sensitivity

18
Q
  • chronic
  • non infectious inflam disease
  • involve many organs
  • more likely to occur in women
  • Tissue injury: caused by autoantibodies and immune complexes
  • depressed suppressor T cell
  • butterfly rash
  • vasculitis
A

Systemic lupus erythematosus

19
Q
  • chronic
  • noninfectious
  • systemic inflam
  • primarily affects joint
  • women are more affected
  • production of IgG or IgM ab against IgG
  • anorexia
  • morning stiffness
  • joint pain
  • inrcease ESR, CRP
  • (+) RF, croglobulins
A

Rheumatoid arthritis

20
Q
  • inflam of salivary and lacrimal glands
  • causes dryness of mouth and eyes
  • polyclonal hypergammaglobulinemia
  • (+) RF, ANA (speckled/diffuse pattern)
  • Anti-SSA
  • Anti-SSB
A

Sjogren syndrome

21
Q
  • increase RBC destruction
  • normocytic, normochromic anemia
  • autoab directed against RBC antigens
    (+) DAT and sometimes cold agglutinins
A

Autoimmune hemolytic anemia

22
Q
  • Humoral and cellular immunity activated
  • loss of thyroid function
  • low levels of thyroid hormones
  • antithyroid antibodies
  • CA-2
  • microsomal antigen
A

Hashimoto disease

23
Q
  • hyperplasia
  • diffuse goiter
  • autoab reacting with thyroid receptor
  • overstimulates thyroid gland: Thyrotoxicosis
  • autoan mimics activity of TSH
  • T3, T4 increase
  • TSH decrease
  • Exophthalmos (bulging eyes)
  • infiltrative dermopathy
A

Graves disease

24
Q
  • nerve muscles do not function normally
  • antibodies to acetylcholine receptors
A

Myasthenia graves

25
- chronic progressive inflam - demyelinization of the nerves - EBV - HHV-6 - active lesions (plaque): ctls, T helper, macrophages - ↑ IgG conc in CSF - oligocloral bands in CSF
Multiple sclerosis
26
- Islet cell destruction in the pancrease - insulin dependent - Autoab and CTLs reactive against pancreatic beta cells - molecular mimicry - HLA-DQ1.2 decrease the risk - HLA-DR2 decrease risk
Type 1 DM
27
Overreactive immune response to innocuous substances on reexposure that can result in tissue damage
Hypersensitivity reaction
28
Humoral mediate and immediate
Types 1-3 hypersensitivity
29
cell mediated and delayed
Type IV hypersensitivity
30
Molecule that triggers a hypersensitivity reaction
Allergen
31
- anaphylactic - immediate - after primary esposure, basophils and mast cells are sensitized with IgE - Second exposure = IgE binds to specific allergen and chemical mediators
Type I hypersensitivity
32
least common form of type I hypersensitivity reactions
food allergies
33
is the systemic form of type I hypersensitivity. It can be life threatening, causing shock or edema of the upper respiratory tract. Substances that can trigger this condition include peanuts; seafood; egg albumin; honeybee, wasp, or hornet stings; vaccines; penicillins; or sulfonamides.
Anaphylaxis
34
- causes contraction of bronchioles and smooth muscle of blood vessels - ↑ capillary permeability - ↑mucus secretion
Histamine
35
- vasodilation - vascular permeability
Prostaglardins
36
- erythema - wheal - bronchospasm - stimulate mucus secretion
Leukotrienes
37
Lab eval of type I hypersensitivity
- total serum IgG levels - allergen-specific IgE
38
Treatment type I hypersensitivity
- Allergen avoidance - drug therapy - immunotherapy (hyposensitization)

IMMUNOSERO 2 (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions