CKD - Epi, Path, and Progression Flashcards Preview

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Flashcards in CKD - Epi, Path, and Progression Deck (11):
1

What's the (arbitrary) time cutoff for "chronic" kidney disease?

3 months

2

3 things to be done when a patient has ESRD (or as this lecture calls it, ESKD)?

Hemodialysis
Peritoneal dialysis
Kidney transplant
(more on these soon)

3

Common glomerular pathology associated with CKD?

Glomerulosclerosis

4

Common interstitial pathology associated with CKD?

Tubular atrophy and interstitial fibrosis.

5

3 kidney things (2 aspects of function, 1... measurable thing) that decline/get worse with age?

GFR (important for drug dosing)
Vascular Auto-regulation
Kidney size/mass

6

What's the deal with error in estimates of GFR?
What does this have to do with 60 ml/min/1.73m^2 being the cutoff for CKD?

There's less error at lower GFR, more error at higher GFR.
60 is an arbitrary cutoff below which you can be pretty confident that the actual GFR is that low.

7

By far, the leading cause of ESRD is...

Diabetes Mellitus
then HTN (though it can be hard to separate out the two)

8

Racial disparities in ESRD?

ESRD has the greatest in African Americans, then Native Americans, then others.

9

Yearly mortality rate for ESRD with dialysis?

18%

10

ESRD kills many people, damages quality of life, and costs the health care system over $20billion/yr.

Yeah.

11

Lower eGFR -> more CVD events and hospitalization.
Proteinuria's bad, too.

right