Claisen and Cross Claisen condensation Flashcards by Khristine Tapado

Which of the following is a product formed in Claisen
condensation?
a) β- ester
b) β-ketone
c) β-keto ester
d) Y-diketone

a) β- ester

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Which type of precursor is used as reactant in
intramolecular Claisen condensation?
a) One molecule with an ester end
b) Two molecules of ester
c) One molecule with two ester ends
d) One molecule of ester and enolate

c) One molecule with two ester ends

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Which of the following stamen is incorrect about Claisen
condensation?
a) The product is a β-keto ester which resists
deprotonation by the strong base in the reaction mixture
b) The reaction involves the condensation of two esters in
the presence of strong base
c) A strong base is required to remove H+ from an α-H
position in one of the starting esters
d) A strong base is required to remove H+ from an α-H
position in one of the starting esters

a) The product is a β-keto ester which resists

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Lye is used in soap-making. Lye is a concentrated
solution of which ionic compound?
a) K2CO3
b) CuSO4
c) NaOH
d) NaCl

a) K2CO3

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Which of the following term describe saponification?
a) Cleaving of ester molecules into carboxylic acid and
alcohol
b) Dehydration synthesis by removing water
c) Hydrolysis of a salt by adding a weak acid
d) Synthesis of two alkyl groups to make an ether

a) Cleaving of ester molecules into carboxylic acid and
alcohol

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Which of the following is considered a useful alkali in
saponification reactions?
a) CCl4
b) Cl–
c) NaOH
d) Pb+

c) NaOH

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Saponification value is the number of milligrams of KOH
required to saponify what present in the 1g of oil or fat?
a) Salts
b) Hydrocarbon
c) Fatty acids
d) unsaturation

c) Fatty acids

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Which of the following is a product formed in Claisen
condensation?
a) β- ester
b) β-ketone
c) β-keto ester
d) Y-diketone

c) β-keto ester

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Which of the following compound is an industrial
manufacturing product by saponification?
a) Sodium chloride
b) Potassium hydroxide
c) Glycerol
d) Sodium hydroxide

c) Glycerol

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Which of the following fat or oil is unsaponifiable?
a) Paraffin wax
b) Bee wax
c) Olive oil
d) Shea butter

a) Paraffin wax

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Which of the following statement is true about
saponification value of oil?
a) The shorter the chain of fatty acid, the higher is the
saponification value
b) The shorter the chain of fatty acid, the higher is the
saponification value
c) The higher the saturation in chain of fatty acid, the
lower is the saponification value
d) The lower the saturation in chain of fatty acid, the
higher is the saponification value

a) The shorter the chain of fatty acid, the higher is the
saponification value

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Soap can be precipitated out by salting by using which
chemical compound?
a) Sodium chloride
b) Potassium hydroxide
c) Glycerol
d) Sodium hydroxide

a) Sodium chloride

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Which of the following stamen is incorrect about Claisen
condensation?
a) The product is a β-keto ester which resists
deprotonation by the strong base in the reaction mixture
b) The reaction involves the condensation of two esters in
the presence of strong base
c) A strong base is required to remove H+ from an α-H
position in one of the starting esters
d) A strong base is required to remove H+ from an α-H
position in one of the starting esters

a) The product is a β-keto ester which resists
deprotonation by the strong base in the reaction mixture

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Which type of precursor is used as reactant in
intramolecular Claisen condensation?
a) One molecule with an ester end
b) Two molecules of ester
c) One molecule with two ester ends
d) One molecule of ester and enolate

c) One molecule with two ester ends

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Dieckmann Condensation is intramolecular
condensation of ……. to form cyclic product.
a) diamide
b) diol
c) diester
d) diketone

c) diester

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What is the other name for the intramolecular Claisen
condensation?
a) Perkin condensation
b) Stobbe condensation
c) Knoevenagel condensation
d) Dieckmann condensation

d) Dieckmann condensation

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Ethylamine can be prepared by the action of bromine
and caustic potash on which compound?
a) Acetamide
b) Propionamide
c) Formamide
d) Methyl cyanide

b) Propionamide

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The amine formed from an amide by means of bromine
and alkali has how many number of carbon atoms?
a) Same number of C atoms as that of amide
b) One less C atom than that of amide
c) One more C atom than that of amide
d) Two more C atoms than that of amide

b) One less C atom than that of amide

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When methyl iodide is heated with ammonia, what is
the product obtained?
a) Methylamine
b) Dimethylamine
c) Trimethylamine
d) A mixture of the above three amines

d) A mixture of the above three amines

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Reduction of nitroalkanes yields which compound?
a) Acid
b) Alcohol
c) Amine
d) Diazo compounds

b) Alcohol

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Which one of the following compound gives a secondary
amine on reduction?
a) Nitromethane
b) Nitrobenzene
c) Methyl isocyanide
d) Methyl cyanide

c) Methyl isocyanide

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The Hinsberg’s method is used for which of the
following?
a) Preparation of primary amines
b) Preparation of secondary amines
c) Preparation of tertiary amines
d) Separation of amine mixtures

d) Separation of amine mixtures

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What is the name of the reaction when acetamide
changes into methylamine?
a) Hofmann bromamide reaction
b) Hofmann reaction
c) Friedel-Craft’s reaction

a) Hofmann bromamide reaction

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When ethanol is mixed with ammonia and passed over
alumina the compound formed is which compound?
a) C2H5NH2
b) C2H4
c) C2H5OC2H5
d) CH3OCH3

a) C2H5NH2

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4. Which of the following reactions will not give primary amine? a) CH3CONH2 + KOH.Br2 b) CH3CN + LiAlH4 c) CH3NC + LiAlH4 d) CH3CONH2 + LiAlH4

c) CH3NC + LiAlH4

9. Which type of amine is produced by reaction of ketones with primary amines, followed by reduction? a) Secondary Aromatic amine b) N-substituted amine c) N, N-disubstituted amine

b) N-substituted amine

10. Which type of amine is produced by reaction of ketones with secondary amines, followed by reduction? a) Secondary Aromatic amine b) N-substituted amine c) N, N-disubstituted amine d) Primary aromatic amine

c) N, N-disubstituted amine

5. What is the characteristic smell of liquid amines? a) Fish like smell b) Rotten egg smell c) Fruity smell d) Bitter almond smell

a) Fish like smell

6. Which of the following have less melting point than amine? a) Alcohol b) Phosphine c) Carboxylic acid d) Ether

b) Phosphine

1. Which of the following compound is expected to be most basic? a) Aniline b) Methylamine c) Hydroxylamine d) Ethylamine

d) Ethylamine

2. A solution of methyl amine shows which type of property with litmus paper? a) Turns blue litmus red b) Turns red litmus blue c) Does not affect red or blue litmus d) Bleaches litmus

b) Turns red litmus blue

3. Which of the following statement is true about methyl amine? a) Methyl amine is slightly acidic b) Methyl amine is less basic than NH3 c) Methyl amine is stronger base than NH3 d) Methyl amine forms salts with alkali

c) Methyl amine is stronger base than NH3

4. By the presence of a halogen atom in the ring, what is the effect of this on basic properties of aniline? a) Increased b) Decreased c) Unchanged d) Doubled

a) Increased

12. If methyl is alkyl group, then which order of basicity is correct? a) R2NH > RNH2 > R3N > NH3 b) R2NH > R3N > RNH2 > NH3 c) RNH2 > NH3 > R2NH > R3N d) NH3 > RNH2 > R2NH > R3N

a) R2NH > RNH2 > R3N > NH3

10. Which statement is an incorrect statement? a) Amines form hydrogen bond b) Ethyl amine has higher boiling point than propane c) Methyl amine is more basic than ammonia d) Dimethyl amine is less basic than methyl amine

d) Dimethyl amine is less basic than methyl amine

7. Which of the following amine has highest boiling point? a) Butyl amine b) Diethylamine c) Triethylamine d) Dipropylamine

d) Dipropylamine

9. Unpleasant smelling carbylamines are formed by heating alkali and chloroform with which of the following? a) Any amine b) Any aliphatic amine c) Any aromatic amine d) Any primary amine

d) Any primary amine

8. What is the correct decreasing order of the basic character of the three amines and ammonia? a) NH3 > CH3NH2 > C2H5NH2 > C6H5NH2 b) C2H5NH2 > CH3NH2 > NH3 > C6H5NH2 c) C6H5NH2 > C2H5NH2 > CH3NH2 > NH3 d) CH3NH2 > C2H5NH2 > C6H5NH2 > NH3

b) C2H5NH2 > CH3NH2 > NH3 > C6H5NH2

11. Which of the following is most basic? a) C6H5NH2 b) (CH3)2NH c) (CH3)3N d) NH3

b) (CH3)2NH

13. Among the following, which one is the strongest base? a) C6H5NH2 b) p−NO2C6H4NH2 c) m−NO2−C6H4NH2 d) C6H5CH2NH2

d) C6H5CH2NH2

14. Which of the following is true characteristic feature of aniline? a) Colourless solid b) Brown coloured solid c) Colourless liquid d) Brown coloured liquid

c) Colourless liquid

15. The correct order of basicity of amines in water is which of the following? a) (CH3)2NH > (CH3)3N > CH3NH2 b) CH3NH2 > (CH3)2NH > (CH3)3N c) (CH3)3N > (CH3)2NH > CH3NH2 d) (CH3)3N > CH3NH2 > (CH3)2NH

a) (CH3)2NH > (CH3)3N > CH3NH2

1. Which of the following is converted into an alcohol on treatment with HNO2? a) Methyl amine b) Aniline c) Dimethyl amine d) Triethyl amine

a) Methyl amine

2. The action of nitrous acid on ethyl amine gives which of the following? a) Ethane b) Ammonia c) Ethyl acohol d) Nitroethane

c) Ethyl acohol

5. p-chloroaniline and anilinium hydrochloride can be distinguished by which test? a) Sandmeyer reaction b) NaHCO3 c) AgNO3 d) Carbylamine test

b) NaHCO3

6. Nitroso amines (R2N−N=O) are soluble in water. On heating them with concentrated H2SO4 they give secondary amines. What is this reaction called as? a) Perkin’s reaction b) Fittig’s reaction c) Sandmeyer’s reaction d) Liebermann’s nitroso reaction

d) Liebermann’s nitroso reaction

4. Aniline reacts with acetaldehyde to form which of the following? a) Schiff’s base b) Carbylamine c) Immine d) Diazonium salt

c) Immine

10. Primary amines can be distinguished from secondary and tertiary amines by reacting with which of the following? a) Chloroform and alcoholic KOH b) Methyl iodide c) Chloroform alone d) Zinc dust

a) Chloroform and alcoholic KOH

7. Ethyl amine undergoes oxidation in the presence of KMnO4 to form which compound? a) An acid b) An alcohol c) An aldehyde d) A nitrogen oxide

c) An aldehyde

9. When primary amines are treated with HCl, the product obtained is which of the following? a) An alcohol b) A cyanide c) An amide d) Ammonium salt

d) Ammonium salt

8. Reaction of primary amines with aldehyde yields which of the following compound? a) Amides b) Aldimines c) Nitriles d) Nitro compounds

b) Aldimines

12. The compound which on reaction with aqueous nitrous acid on HNO2 at low temperature produces an oily nitrosoamine is which of the following? a) Diethylamine b) Ethylamine c) Aniline d) Methylamine

a) Diethylamine

14. When an organic compound was treated with sodium nitrite and hydrochloric acid in the ice cold, nitrogen gas was evolved copiously. What is the compound? a) A nitrocompound b) A primary amine c) An aliphatic primary amine d) An aromatic primary amine

c) An aliphatic primary amine

11. When chloroform reacts with ethyl amine in presence of alcoholic KOH, the compound formed is which of the following? a) Ethyl cyanide b) Ethyl isocyanide c) Formic acid d) An amide

b) Ethyl isocyanide

16. The reaction of HNO2 with ‘A’ gives quaternary ammonium salt. A is which of the following? a) Methyl amine b) Dimethyl amine c) Trimethyl amine d) Aniline

c) Trimethyl amine

13. Aniline on treatment with excess of bromine water which of the following? a) Aniline bromide b) o-bromoaniline c) p-bromoaniline d) 2, 4, 6-tribromoaniline

d) 2, 4, 6-tribromoaniline

1. A primary amine can be converted to an alcohol by the action of which of the following? a) Alkali b) Nitrous acid c) Reducing agent d) Oxidizing agent

b) Nitrous acid

2. The amine which can react with C6H5−SO2−Cl to form a product insoluble in alkali shall be, is which of the following? a) Primary amine b) Secondary amine c) Tertiary amine d) Both primary and secondary amines

b) Secondary amine

15. Primary amines react with nitrous acid to yield which of the following? a) Insoluble nitrite salts b) Yellow oily layer c) Nitrogen gas d) Azo dye

3. A mixture of benzene and aniline can be separated by which of the following? a) Hot water b) dil. HCl c) dil. NaOH d) Alcohol

b) dil. HCl

14. Nitration of aniline also gives m-nitro aniline, in strong acidic medium because of which of the following reasons? a) In electrophilic substitution reaction amino group is meta directive b) Inspite of substituents nitro group always goes to m- position c) In strong acidic medium, nitration of aniline is a nucleophic substitution reaction d) In strong acidic medium aniline present as anilinium ion

b) Inspite of substituents nitro group always goes to m- position

4. An organic amino compound reacts with aqueous nitrous acid at low temperature to produce an oily nitroso amine. What is this compound? a) CH3NH2 b) CH3CH2NH2 c) CH3CH2NH.CH2CH3 d) (CH3CH2)3

b) CH3CH2NH2

5. Reaction of aniline with benzaldehyde is which type of reaction? a) Polymerisation b) Condensation c) Addition d) Substitution

b) Condensation

7. Electrophilic substitution of aniline with bromine in presence of gacial acetic acid gives which of the following? a) 1, 4, 6-tribromo aniline b) 2, 4, 6-tribromo aniline c) 4-bromo aniline d) 3-bromo aniline

c) 4-bromo aniline

6. In the reaction, what is the compound C6H5N=CHC6H5is known as? C6H5CHO + C6H5NH2 → C6H5N=HCC6H5 + H2O a) Aldol b) Schiffs reagent c) Schiffs base d) Benedict reagent

c) Schiffs base

9. Ethyl amine on acetylation gives which of the following? a) N-ethyl acetamide b) Acetamide c) Methyl acetamide d) Propyl acetamide

a) N-ethyl acetamide

8. During acetylation of amines what is replaced by acetyl groups? a) Hydrogen atom attached to nitrogen atom b) One or more hydrogen atoms attached to carbon atom c) One or more hydrogen atoms attached to nitrogen atom d) Hydrogen atoms attached to either carbon atom or nitrogen atom

c) One or more hydrogen atoms attached to nitrogen atom

12. Aniline reacts with which of these to form Schiff base? a) Acetic acid b) Benzaldehyde c) Acetone d) NH3

b) Benzaldehyde

10. p-chloro aniline and anilinium hydrogen chloride can be distinguished by which of the following? a) Sandmaeyer reaction b) Carbyl amine reaction c) Hinsberg’s reaction d) AgNO3

d) AgNO3

1. Aniline is usually purified by which of the following method? a) Steam distillation b) Simple distillation c) Vacuum distillation d) Extraction with a solvent

a) Steam distillation

13. Reaction of cyclohexanone with dimethylamine in the presence of catalytic amount of an acid forms a compound if water during the reaction is continuously removed. What is the compound formed is generally known as? a) A Schiff’s base b) An enamine c) An imine d) An amine

b) An enamine

5. The reductive amination of an aldehyde (e.g. the reaction of propanal with ethylamine) can be carried out in the laboratory using which of the following as a reducing agent? a) NaBH3CN b) LiAlH4 c) BH3 d) NaBH4

a) NaBH3CN

8. Which type medium is required for the formation of aniline by reaction of aryl boric acid and HAS? a) Acidic b) Basic aqueous c) Neutral dry d) aqueous

b) Basic aqueous

10. In the direct amination of alkyl and aryl pinacol boronates to form aromatic amine, which of the following is used as reagent with pinacol? a) Aryl boric acid b) Copper oxide c) Pd(OAc)2 d) Lithiated methoxyamine

d) Lithiated methoxyamine

4. Which reducing agent is used for the reduction of nitro compound to phenyl amine? a) LiAlH4 b) Sn/HCl c) Na/alcohol d) H2/Ni

b) Sn/HCl

2. Which of the following method cannot be used for preparation of aromatic amine? a) Gabriel phthalimide synthesis b) Reduction of nitro compound c) Reduction of nitrile with LiAl4 d) Decarboxylation of amino acids

a) Gabriel phthalimide synthesis

2. What is the known name of the given reaction? C6H5N+ 2 + CuCl → C6H5Cl + N2 + Cu+ a) Gattermanns reaction b) Sandmeyers reaction c) Dehydrogenation reaction d) Esterification reaction

b) Sandmeyers reaction

1. What is the general formula of Diazonium salt? a) RN2^+X^– b) RN^+ c) RXI d) RN_2^+HSO^-2

a) RN2^+X^–

3. What is the known name of the given reaction? C6H5N+ 2 + CuX → C6H5X + N2 + Cu+ a) Gattermanns reaction b) Sandmeyers reaction c) Dehydrogenation reaction d) Esterification reaction

a) Gattermanns reaction

4. What is the known name of the given reaction? [C6H5N+ 2]Cl− + C6H6 → C6H5−C6H5 + N2 + HCl a) Gattermanns reaction b) Sandmeyers reaction c) Gomberg–Bachmann reaction d) Esterification reaction

c) Gomberg–Bachmann reaction

5. What is the known name of the given reaction? [C6H5N+ 2]BF− 4 → C6H5F + BF3 + N2 a) Gattermanns reaction b) Sandmeyers reaction c) Dehydrogenation reaction d) Balz-Schiemann reaction

d) Balz-Schiemann reaction

7. Benzene diazonium chloride when reacts with hypophosphorus acid produces which of the following compound? a) Benzene b) Phenyl phosphate c) Phenol d) Phenyl isocyanide

a) Benzene

6. What is the known name of the given reaction? [C6H5N+2]Cl− + ArCH=CHCO2H → ArC=C−C6H5 + N2 + CO2 + HCl a) Gattermanns reaction b) Sandmeyers reaction c) Meerwein reaction d) Balz-Schiemann reaction

a) Gattermanns reaction

9. When hypophosphorous acid is treated with diazonium salts, it is reduced to which of the following compound? a) Arene b) Methane c) Ethyl alcohol d) Amines

a) Arene

8. p-amino azo benzene is obtained by treating diazonium chloride with which of the following compound? a) Benzene b) Aniline c) Phenol d) Benzoic acid

b) Aniline

10. Which of the following amine will form stable diazonium salt at 273-283 K? a) C6H5NH2 b) C6H5N(CH3)2 c) C2H5NH2 d) C6H5CH2NH2

a) C6H5NH2

10. When diazonium salt solution is treated with KI, it forms which of the following compound? a) Bromobenzene b) Iodobenzene c) Phenol d) Acid

b) Iodobenzene

8. Azo dye is prepared by the coupling of phenol and which of the following compound? a) Diazonium chloride b) o-nitro aniline c) Benzoic acid d) Chlorobenzene

a) Diazonium chloride

4. Benzene diazonium chloride forms orange red dye with which of the following compound? a) Nitrophenol b) Benzophenol c) Resorcinol d) Methanol

c) Resorcinol

1. Replacement of diazo group by other groups is helpful in preparing those substituted aromatic compounds which cannot be prepared which type of reaction? a) Direct elimination b) Addition reaction c) Direct substitution d) Replacement reaction

c) Direct substitution

2. What happens when benzene diazonium chloride is treated with potassium cyanide in presence of Cu powder? a) Benzophenone b) Methyl isocyanide c) Acetonitrile d) Benzonitrile

d) Benzonitrile

3. By treating diazonium salts with cuprous cyanide or KCN and copper powder it forms which of the following compound? a) Citric acid b) Benzoic acid c) Aryl nitrile d) Oxalic acid

c) Aryl nitrile

9. Identify the product in following order when 3,4,5 Tribromoaniline undergoes diazotisation followed by attack of H3PO2? a) 3, 4,5-Tribromobenzene b) 1, 2, 3-Tribromobenzene c) 2, 4, 6-Tribromobenzene d) 3, 4, 5-Tribromo nitro benzene

a) 3, 4,5-Tribromobenzene

10. When diazonium salt solution is treated with KI, it forms which of the following compound? a) Bromobenzene b) Iodobenzene c) Phenol d) Acid

b) Iodobenzene

Claisen and Cross Claisen condensation Flashcards

(94 cards)