Class 5: Autoimmune disorders Flashcards Preview

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Flashcards in Class 5: Autoimmune disorders Deck (17):
0

Diagnosis of AI disorders based on

Existence of auto-AB
Evidence that immune mechanism causing pathological lesion.
Evidence of immune nature of disorder.

1

Systemic Lupus Erythromatosus

Lupus

Malfunction of T suppressor cells which allows polyclonal activation of B cells.

Resultant plasma cells secrete auto-AB

Ab-Ag complexes circulate to other membranes and active complement --> inflammatory diseases.

2

Clinical features of SLE

Highly variable
Butterfly rash
Joint inflammation
Kidney malfunction, anemia

3

What characterizes all immunodeficiency diseases?

Lymphopenia (Low lymphocyte count in peripheral blood)

4

DiGeorge's syndrome

Primary immunodeficiency disease
Aplasia of thymus and aplasia of parathyroid glands.

5

AIDS

Acquired immune deficiency syndrome
Caused by HIV

Affinity for T helper cells and monocytes, macrophages, microglia.

Cytotoxic. Destroys T cells. Depresses cell mediated immunity

6

Phases of HIV/AIDS

Phase of Acute Illness (Group I)
Phase of Asymptomatic infection (Group II)
Phase of Generalizes Lymphadenopathy (Group III)
AIDS (Group IV) (CD4 decrease)

7

Diagnosis of AI disorders based on

Existence of auto-AB
Evidence that immune mechanism causing pathological lesion.
Evidence of immune nature of disorder.

8

Systemic Lupus Erythromatosus

Lupus

Malfunction of T suppressor cells which allows polyclonal activation of B cells.

Resultant plasma cells secrete auto-AB

Ab-Ag complexes circulate to other membranes and active complement --> inflammatory diseases.

9

Clinical features of SLE

Highly variable
Butterfly rash
Joint inflammation
Kidney malfunction, anemia

10

What characterizes all immunodeficiency diseases?

Lymphopenia (Low lymphocyte count in peripheral blood)

11

DiGeorge's syndrome

Primary immunodeficiency disease
Aplasia of thymus and aplasia of parathyroid glands.

12

AIDS

Acquired immune deficiency syndrome
Caused by HIV

Affinity for T helper cells and monocytes, macrophages, microglia.

Cytotoxic. Destroys T cells. Depresses cell mediated immunity

13

Phases of HIV/AIDS

Phase of Acute Illness (Group I)
Phase of Asymptomatic infection (Group II)
Phase of Generalizes Lymphadenopathy (Group III)
AIDS (Group IV) (CD4 decrease)

14

Cancers most associated with AIDS

Kaposi's sarcoma and lymphomas

15

Amyloidosis

Multifactorial disease caused by abnormalities of the immune system or abnormal response to chronic infection.

Marked by a build-up of amyloid in tissues, usually in extra-cellular spaces.

Systemic or local

In brain --> Alzheimer's

16

Amyloid

A fibrillin protein formed into a beta pleated sheet.