Flashcards in Class: Papilloma, Polyoma, Parvo Deck (49):
What kinds of cancer are caused by HPV (6)
99% cervical cancers
vuvlar, vaginal, penile
What are the high risk HPV types most assocuated with cancers
What does a low risk E6 viral protein do vs high risk
low = does not inactivate p53
high = inactivates p53
What does a high risk E7 viral protein do vs low risk?
low = weakly binds and does not degrade Rb
high = binds and degrades Rb
What is the AIDs defining cancer in HIV+ woman
The incidence of what cancers are higher in the HIV+ population
anal and oropharyngeal
What HPV type causes common warts (verrucus vulgaris)
What HPV type causes Plane warts or flat warts (verrucae plana)
types 3, 10
What HPV type causes Plantar warts (verrucae plantaris)-
types 1, 2
what is epidermodysplasia verruciform? Inheritance pattern?
AR - chronic infection of cutaneous HPV
What HPV types are assc with epidermodysplasia verruciform
types 3, 10
what is recurrent respiratory papillomatosis ?
warts that appear in larynx and spread to lung
How does recurrent respiratory papillomatosis present? (3)
warts in resp tract
hoarseness is first sx
difficulty swallowing or breathing while sleeping
What HPV types causerecurrent respiratory papillomatosis
types 6, 11
how is recurrent respiratory papillomatosis transmitted in Juvenile and adult
juvenile = birth
adult = oral sex
3 treatments of recurrent respiratory papillomatosis
IFN or cidofovir to reduce time between surgeries
in Cervarix vaccine what HPV virus types are present?
Gardasil: quadrivalent, vaccine what virus types are present?
HPV 6, 11, 16, 18
Gardasil 9: 9-valent, what types are repsent?
HPV 6, 11, 16, 18 and 10% of other high risk HPV’s
What is the optimal age of HPV vaccination?
How many shots do the following age groups get?
15- 21 (boys), -26 (girls)
9 = 2 doses
11-14 = 2 doses
15-21 get 3 doses
cervarix only approved for who
Gardasil bi- and quadrivalent approved for what pop?
boys and girls
who is at risk for PML? (3)
1. AIDs pts
2. Immunosuppressed -dt transplant, hematologic malignancies
3. Those on immunosuppressive thx: Crohn’s, MS, rheumatoid arthritis, psoriasis, SLE
What virus (and family) causes PML?
JC virus (polyoma family)
Why such a small incidence of PML even in the immune suppressed?
Several steps are needed to get to PML from a JC infection:
What are the 3 steps needed to cause PML
1. virus needs to change to infect glial cells
2. needs to get to brain
3. needs to evade immune surveillance in brain
What cells does PML infect?
infects oligodendrocytes and astrocytes
How does PML cuase it's sx?
causes a multifocal demyelination of the white mater
What does IRIS stand for
(Immune Reconstitution Inflammatory Syndrome)
What is IRIS associated with and what increases risk?
associated with use of immunosuppressant Natalizumab
increased risk with increased time on drug
tx for IRIS
What 2 problems does BK virus cause in kidney transplant pts
some develop BK-associated nephropathy
of those 50% reject the trasnplant
What problems arise in Bk- infected allogenic hematopoietic stem cell transplant pts
increased risk for hemorrhagic cystitis
What cell is found in urine of BK pt
what virus causes erythema infectiosum
How is parvovirus B-19 transmitted. (2)
TORCHES = congential
What is parvovirus B-19 receptor?
globoside (also known as blood group P antigen).
How is erythema infectiosum transmitted.
resp droplets and fomites
wHAT CELL TYPE IS TARGET FOR parvovirus? why?
erythroid precursor cells
In order to replicate needs to infect cells that are actively dividing
How does erythema infectiosum presetn in children
fever--> slapped cheek rash --> recovery
How does erythema infectiosum presetn in adults
arthritis/arthralgia in small joints in hands, and feet (also knee)
What can erythema infectiosum be mistaken for in adults?
Two main complications of erythema infectiosum
Transient aplastic crisis (TAC)
Pure Red Cell Aplasia
In what pop does Pure Red Cell Aplasia occur
In what pop does Transient aplastic crisis (TAC) occur
people with hemoglobinopathies: MC = SSD, but also
thalassemia, hereditary spherocytosis, red cell enzymopathies, and autoimmune hemolytic anemia.
what the outcome can be for pregnant women infected with B19.
high output cardiac failure and non-immune hydrops fetalis.
When during gestation does parvo B-19 infx becomes most problematic
Highest risk is in first 20 weeks of pregnancy