Class: Papilloma, Polyoma, Parvo Flashcards Preview

D&T test 5 - Renal, Urogential > Class: Papilloma, Polyoma, Parvo > Flashcards

Flashcards in Class: Papilloma, Polyoma, Parvo Deck (49):
1

What kinds of cancer are caused by HPV (6)

99% cervical cancers
Anal cancers
vuvlar, vaginal, penile
oropharyngeal cancers

2

What are the high risk HPV types most assocuated with cancers

16, 18

3

What does a low risk E6 viral protein do vs high risk

low = does not inactivate p53
high = inactivates p53

4

What does a high risk E7 viral protein do vs low risk?

low = weakly binds and does not degrade Rb
high = binds and degrades Rb

5

What is the AIDs defining cancer in HIV+ woman

cervical

6

The incidence of what cancers are higher in the HIV+ population

anal and oropharyngeal

7

What HPV type causes common warts (verrucus vulgaris)

types 1,2,4

8

What HPV type causes Plane warts or flat warts (verrucae plana)

types 3, 10

9

What HPV type causes Plantar warts (verrucae plantaris)-

types 1, 2

10

what is epidermodysplasia verruciform? Inheritance pattern?

AR - chronic infection of cutaneous HPV

11

What HPV types are assc with epidermodysplasia verruciform

types 3, 10

12

what is recurrent respiratory papillomatosis ?

warts that appear in larynx and spread to lung

13

How does recurrent respiratory papillomatosis present? (3)

warts in resp tract
hoarseness is first sx
difficulty swallowing or breathing while sleeping

14

What HPV types causerecurrent respiratory papillomatosis

types 6, 11

15

how is recurrent respiratory papillomatosis transmitted in Juvenile and adult

juvenile = birth
adult = oral sex

16

3 treatments of recurrent respiratory papillomatosis

frequent surgeries
IFN or cidofovir to reduce time between surgeries
Indole-3 carbinol

17

in Cervarix vaccine what HPV virus types are present?

Bivalent-16,18 only

18

Gardasil: quadrivalent, vaccine what virus types are present?

HPV 6, 11, 16, 18

19

Gardasil 9: 9-valent, what types are repsent?

HPV 6, 11, 16, 18 and 10% of other high risk HPV’s

20

What is the optimal age of HPV vaccination?

11-12

21

How many shots do the following age groups get?
9
11-14
15- 21 (boys), -26 (girls)

9 = 2 doses

11-14 = 2 doses

15-21 get 3 doses

22

cervarix only approved for who

girls

23

Gardasil bi- and quadrivalent approved for what pop?

boys and girls

24

who is at risk for PML? (3)

1. AIDs pts
2. Immunosuppressed -dt transplant, hematologic malignancies
3. Those on immunosuppressive thx: Crohn’s, MS, rheumatoid arthritis, psoriasis, SLE

25

What virus (and family) causes PML?

JC virus (polyoma family)

26

Why such a small incidence of PML even in the immune suppressed?

Several steps are needed to get to PML from a JC infection:

27

What are the 3 steps needed to cause PML

1. virus needs to change to infect glial cells
2. needs to get to brain
3. needs to evade immune surveillance in brain

28

What cells does PML infect?

infects oligodendrocytes and astrocytes

29

How does PML cuase it's sx?

causes a multifocal demyelination of the white mater

30

What does IRIS stand for

(Immune Reconstitution Inflammatory Syndrome)

31

What is IRIS associated with and what increases risk?

associated with use of immunosuppressant Natalizumab
increased risk with increased time on drug

32

tx for IRIS

corticosteroid

33

What 2 problems does BK virus cause in kidney transplant pts

some develop BK-associated nephropathy
of those 50% reject the trasnplant

34

What problems arise in Bk- infected allogenic hematopoietic stem cell transplant pts

increased risk for hemorrhagic cystitis

35

What cell is found in urine of BK pt

decoy cells

36

what virus causes erythema infectiosum

Parvovirus B-19

37

How is parvovirus B-19 transmitted. (2)

respiratory droplets
TORCHES = congential

38

What is parvovirus B-19 receptor?

globoside (also known as blood group P antigen).

39

How is erythema infectiosum transmitted.

resp droplets and fomites

40

wHAT CELL TYPE IS TARGET FOR parvovirus? why?

erythroid precursor cells
In order to replicate needs to infect cells that are actively dividing

41

How does erythema infectiosum presetn in children

fever--> slapped cheek rash --> recovery

42

How does erythema infectiosum presetn in adults

arthritis/arthralgia in small joints in hands, and feet (also knee)

43

What can erythema infectiosum be mistaken for in adults?

Rheumatoid arthritis

44

Two main complications of erythema infectiosum

Transient aplastic crisis (TAC)
Pure Red Cell Aplasia

45

In what pop does Pure Red Cell Aplasia occur

immunosuppressed

46

In what pop does Transient aplastic crisis (TAC) occur

people with hemoglobinopathies: MC = SSD, but also
thalassemia, hereditary spherocytosis, red cell enzymopathies, and autoimmune hemolytic anemia.

47

what the outcome can be for pregnant women infected with B19.

high output cardiac failure and non-immune hydrops fetalis.

48

When during gestation does parvo B-19 infx becomes most problematic

Highest risk is in first 20 weeks of pregnancy

49

What is major complication of fetal B-19 infx and MOA

B19 infects fetal myocytes expressing the P-antigen --> myocarditis--> hydrops fetalis