Pathoma 12.4 Nephritic syndromes Flashcards Preview

D&T test 5 - Renal, Urogential > Pathoma 12.4 Nephritic syndromes > Flashcards

Flashcards in Pathoma 12.4 Nephritic syndromes Deck (37):
1

What are the two chcs of nephritic syndromes

Glomerular Infl and bleeding = hematuria

2

proteinuria level in nephritic syndrome

< 3.5g/day

3

What is seen in urine in Nephritic syndome (2)

RBC casts and dysmorphic RBCS

4

electrolyte status in nephritic syndrome

salt retention

5

salt retention leads to what two sequelae in Nephritic synd

periorbital edema and HTN

6

Is azotemia present in Nephritic Synd

yes

7

Biopsy of GLom in neph syndrome

hypercellular, inflammed glomeruli

8

What mediates damage in nephritic Sn (4)

IC deposition activates complement.
C5a attracts neutrophils which do the damage

9

After a GAS infx what NS arises

Poststretococcal Glomerulonephritis (PSGN)

10

What defines a nephritogenic strain of GAS?

M-protein antigen

11

4 things PSGN presents as

hematuria- coke colored urine
oliguria
HTN
periorbital edema

12

PSGN usually occurs in what pop

children

13

What hallmark is seen in EM with PSGN

subepithelial 'humps'

14

What is the IF in PSGN

granular deposits

15

Crescents in Bowman's space are comprised of what 2 things

fibrin and macrophages

16

Crescents in BS signify what NS?

Rapidly Progressive Glomerulonephritis (RPGN)

17

RPGN has 6 possible etiologies: name them

Goodpasture syndrome
PSGN
Diffuse Proliferative GN
Wegner's Granulomatosis
Churg Strauss syndrome
Microscopic Polyangiitis

18

What IF finding points to Goodpasture as etiology of RPGN

Linear IF

19

What causes linear IF on Goodpasture

Anti-GBM antibody

20

What 3 organ systems are affected in Wegner's

nasopharynx
lungs
kidneys

21

What is presentation of Goodpasture synd (2)

hematuria, hemoptysis

22

Grnaular IC deposition on IF points to what 2 dx?

PSGN
Diffuse Proliferative GN

23

Goodpasture classically presents in what pop

young adult males

24

What is the MC renal disease in SLE

Diffuse Proliferative GN

25

c-ANCA and p-ANCA are associated with what syndromes, respectively (3)

c-ANCA = WeCner's (Wegner's)
p-ANCA = Churg Strauss or microscopic polyangiitis

26

What 3 things are present in Churg-Strauss that differentiate it from microscopic polyangiitis?

granulomatous infl
eosinophilia
asthma

27

Berger Disease (aka?) shows deposition where?

IgA nephropathy
IgA deposits in the mesangium

28

What is the MC nephropathy worldwide

IgA nephropathy

29

IgA nephropathy follows what

mucosal infx (gastroenteritis)--> increased IgA production

30

How does IgA neph present?

in childhood with gross or microscopic hematuria

31

IF in IgA neph

shows mesangial deposition

32

progression of IgA Neph

slowly toward renal failure

33

Alport Syndrome is a defect in what

type IV collagen

34

Most common inheritance pattern for Alport Syndr

X-linked

35

What happens to GBM in Alport synd (2)

"thinning and splitting"

36

What is the presentation of Alport Synd (3)

hearing loss (sensory), ocular disturbances, oliguria

37

hallmark of Alport

isolated Hematuria