Classes 22-23 Cohort Studies Flashcards Preview

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Flashcards in Classes 22-23 Cohort Studies Deck (32)
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1

Cohort studies

Observational, analytical studies allowing researcher to be a passive observer of natural events occurring in naturally-exposed and unexposed (comparison) groups

2

In Cohort studies, group-allocation is based on:

Exposure-status or group membership (something in common)

3

When are Cohort studies useful?

Useful when studying a rare exposure

4

What are other names for Cohort studies?

Incidence studies
Follow-up studies
Longitudinal studies

5

Cohort studies commonly generate the ____ ____ as a measure of association

Risk Ratio (RR)

6

Reasons to select a Cohort design

Unable to "randomize"
Limited resources
Exposure of interest is rare
More interested in incidence rates/predictors of or risks for outcome of interest

7

True or False:
Cohort studies can only be done in a prospective fashion.

False
They can be conducted in a prospective, retrospective, or ambidirectional fasion.

8

Prospective Cohort Studies

Exposure group is selected on the basis of a past or current exposure and both groups followed into the future to assess for outcome(s) of interest, and then compared

9

Retrospective Cohort Studies

At the start of the study, both the exposure and the outcome of interest have occurred
Exposure still has to occur before outcome of interest & group allocation is based on exposure status, not disease status

10

Ambidirectional Cohort Studies

Uses retrospective design to assess past differences but adds all data collected on additional outcomes prospectively from start of study (looking for outcomes in the past and into the future)

11

Birth Cohort

Individuals assembled based on being born in a geographic region in a given time period

12

Inception Cohort

Individuals assembled at a given point based on some common factor (ex. Framingham study and Nurses' health study)

13

Exposure Cohort

Individuals assembled based on some common exposure (frequently connected to environmental or other one-time event)

14

Fixed Cohort

A cohort (derived from an irrevocable event) which can't gain members but can have loss-to-follow-ups

15

Closed Cohort

A fixed cohort with no loss-to-follow-ups

16

Open (or Dynamic) Cohort

A cohort with new additions and some loss-to-follow-ups (can increase or decrease over time)

17

How to select an Exposed study population

The easier part
Allocate subject based on pre-defined criteria of "exposure"

18

How to select an Unexposed study population

Make the groups as close as possible (coming from the same cohort/population (yet not exposed))
Can come from 3 sources: Internal, general population, or comparison cohort

19

Unexposed group from INTERNAL source

Patients from the same "cohort", yet who are unexposed (most similar)
If there are only levels of exposure, you may have to use the lowest exposure group as comparator

20

Unexposed group from GENERAL POPULATION source

Used as a second choice when the best-possible comparison group (internal) is not realistically possible (e.g., everyone is exposed; or the exposure subjects were drawn from the general population)
Randomly selecting

21

Unexposed group from COMPARISON COHORT source

Least acceptable group
Simply attempt to match groups as close as possible on numerous personal characteristics (can't control for other potentially harmful exposures in comparison cohort; also causing disease)

22

Strengths of Cohort Studies

Good for assessing multiple outcomes of one exposure
Useful when exposures are rare
Useful in calculating risk and RR's
Less expensive than interventional trial
Good when ethical issues limit use of intervention
Good for long induction/latent periods (retrospective)
Able to represent "temporality" (prospective)

23

Advantages of Prospective Cohort Studies

Can obtain a greater amount of study-important info from patients
Follow-up/Tracking of patients may be easier
Better at giving answer to "temporality"
May look at multiple outcomes form a (supposed) single exposure
Can calculate incidence & incidence rates

24

Disadvantages of Prospective Cohort Studies

Time, expense, and loss-to-follow-up's
Not efficient for rare diseases
Not suited for long induction/latency conditions
Exposure (or its "amount") may change over time

25

Loss to Follow-Up

Possible with prospective cohorts
Lower sample size (power)
- increased risk of type 2 error
- loss of study participation may not be equal between groups
Do ALL you can (and think of) to limit LTFU's

26

Advantages of Retrospective Cohort Studies

Best for long induction/latency conditions
Able to study rare exposures
Useful if the data already exists
Saves time and money compared to prospective studies

27

Disadvantages of Retrospective Studies

Requires access to charts, databases, employment records
Information may not factor in or control for other exposures to harmful elements
Patients may not be available for interview if contact necessary for missing/incomplete data
Exposure (or its "amount") may have changed over time

28

Issues affecting outcome occurrence in groups:

Level of exposure
Induction Period
Latency Period

29

Induction period

Interval between exposure which causes disease and onset of disease-process

30

Latency period

Interval between disease-process onset & clinical diagnosis of disease