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Immunoserology > Classes of Immunoglobulins > Flashcards

Classes of Immunoglobulins Flashcards

1
Q

Predominant in healthy humans

A

IgG

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2
Q

Provides immunity to newborn

A

IgG

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3
Q

How does IgG provides immunity to newborn?

A

IgG is the smallest Ig which makes them easily cross the placenta

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4
Q

Subclass(es) of IgG that can cross placenta

A

IgG1 and IgG3

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5
Q

One function of IgG is fixation of complement. Arrange IgG based on the potency from greatest to least: IgG1, IgG2, IgG3.

A

IgG3 –> IgG1 –> IgG2

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6
Q

What are the molecules that enhances phagocytosis?

A

Opsonin

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7
Q

This enhances the phagocytosis by facilitating the linking or cross-bridging of phagocytes and target antigen

A

Opsonization

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8
Q

Type of immunity that provides immunity to the newborn from the maternal antibody

A

Acquired Natural Passive Immunity

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9
Q

This immunoglobulin is predominant antibody in the Secondary or Anamnestic Response

A

IgG

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10
Q

This immunoglobulin is a monomer and has no J Chain

A

IgG

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11
Q

This immunoglobulin is the best precipitating antibody

A

IgG

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12
Q

This immunoglobulin participates in agglutination and precipitation reaction

A

IgG

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13
Q

The four (4) subclasses of IgG are differentiated based on: (2)

A
  1. Concentration in the serum
  2. number of disulfide bonds
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14
Q

Concentration and number of disulfide bonds: IgG1

A

66%
2 disulfide bonds

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15
Q

Concentration and number of disulfide bonds: IgG2

A

23%
4 disulfide bonds

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16
Q

Concentration and number of disulfide bonds: IgG3

A

7%
15 disulfide bonds

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17
Q

Concentration and number of disulfide bonds: IgG4

A

4%
2 disulfide bonds

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18
Q

This immunoglobulin is predominant in primary immune response

A

IgM

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19
Q

This immunoglobulin First antibody displayed on B cell Surface

A

IgM

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20
Q

This immunoglobulin
first to appear in phylogeny and last to leave in senescence

A

IgM

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21
Q

This immunoglobulin
first to appear after a primary antigenic stimulus

A

IgM

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22
Q

Best antibody in terms of fixing the Complement

A

IgM

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23
Q

Biggest antibody – Composed of 5 monomers
(Pentameric Antibody)

A

IgM

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24
Q

Functions of IgM (4)

A

▪ Complement Fixation
▪ Agglutination
▪ Opsonization
▪ Toxin neutralization

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25
Best agglutinating antibody
IgM
26
This immunoglobulin exists as monomer or dimer
IgA
27
IgA is a monomer in:
Plasma
28
IgA is a dimer in:
Secretion
29
Responsible for mucosal immunity
IgA
30
Immunoglobulin that is predominant in secretion/body fluids
IgA
31
Only antibody with secretory component
IgA
32
Responsible in maintaining the structure of antibody by preventing the enzymatic degradation of the structure
secretory component
33
plays a role in the binding of IgA to the Epithelial mucosal surface
Secretory component
34
Function is still unknown but believes to play a role in immunoregulation
IgD
35
Second to IgM to be expressed on the surface of B Lymphocytes
IgD
36
Postulated to be an anti-idiotypic antibody
IgD
37
Least abundant Ig in the healthy serum
IgE
38
IgE is abundant in which type of parasitic infection?
Helminthic
39
IgE is present in which type of hypersensitivity
Type 1 Hypersensitivity
39
IgE is present in which type of hypersensitivity
Type 1 Hypersensitivity
40
Only Ig that binds strongly to mast cell and Basophil receptor
IgE
41
Why can IgE bind to mast cells and basophil?
It has specific receptor to mast cells and basophil
42
Mediator of allergic reaction
Histamine
43
Site for histamine receptor
Basophil and Mast Cell
44
Mast cells are found in:
Tissues
45
Basophils are found in:
Circulation
46
Molecular weight of IgG
150 T
47
Molecular weight of IgA
160 - 400 T
48
Molecular weight of IgM
900 T
49
Molecular weight of IgD
180 T
50
Molecular weight of IgE
190 T
51
Half life of IgG
21-23 days
52
Half life of IgA
5-6 days
53
Half life of IgM
5 days
54
Half life of IgD
2-3 days
55
Half life of IgE
2-3 days
56
Other name for IgG
Serum Ig
57
Other name for IgA
Secretory Ig
58
Other name for IgM
Pentameric Ig
59
Other name for IgE
Reagenic Ig
60
Which complement does IgA activate?
Alternative Pathway only

Immunoserology (4 decks)

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