classification of hemoletic animie

Question 1

how can our body in general conpensate to the hemolytic animia

Answer 1

more RBCs production { erythropiosis}

Question 2

why we check the reticylocyte count in case of hemolytic animia ???

Answer 2

bcs of the compensatry mechanisim in producing more RBCs but instead the retecylocyte the immature form is gonna released

Question 3

the life span of RBCs is …

Answer 3

120

Question 4

RBCs die in the …
1- liver
2- spleen

Answer 4

spleen

Question 5

mention the types of hemolysis?

Answer 5

1- extravasculer

2- intravasculer

Question 6

why the red colored urine is an indication for intravasculer hemolysis??

Answer 6

bcz the free Hb in the blood/urine has a red color

Question 7

mention RBC Membrane Disorders

Answer 7

Hereditary Spherocytosis,Hereditary
Elliptocytosis
, immune mediated hymolisis

Question 8

what is the important of comb test ??

Answer 8

auto-antibodies detection against RBCs

Question 9

if a patient have G6DP defecincy and then ate a fave bean what gonna happened ????

Answer 9

SUFFER from hemyletic animia

Question 10

if a patient have G6DP defecincy ang take antibiotic or got infected what gonna happen ??

Answer 10

provoke the symptom of hymolitic anemia

Question 11

in thalasemia there is AN expanding frontal bone and hair like apperance in Xray ???why.

Answer 11

bcz the patient has a very sever hemolysis that the bone marrow expandeed to consompent

Question 12

symptoms of sickle cell anemia only show up when ………

Answer 12

there is low oxygen

Question 13

HbS is slower than the the Hb normal why ???

Answer 13

bcz in HBS there is less charge

Question 14

in sckilll cell animia the spleen is small why ????

Answer 14

bcs the SCA will occlude blocking the blood supply to the spleen —-> spleen atrophy

Question 15

SCA leads to the leg ulcer why?

Answer 15

bcs the SCA will occlude blocking the blood supply to the leg —> ulcer formation

Question 16

SCA leads to gall stones { }

Answer 16

T

Question 17

WHAT is the RBC component after broken down in the spleen normelly???

Answer 17

• Amino acids
• Fe( iron)
• Bilirubin

Question 18

bilirubin.comes from

Answer 18

protoporphyrin

Question 19

why bilirubin goes to the liver .

Answer 19

bcz it is Not soluble in water

so it will go to liver

Question 20

in what form the RBCs are extravasculer hemyloteic ??

Answer 20

1- antibody coated hemylotic

2- irreguler shape

Question 21

why having an intact membrane matters

Answer 21

Red cell is passing through very narrow vasculature. RBCs is very flexible and can reform and change
back into its original shape.

Question 22

what gonna happened If the spherical loses its central pallor

Answer 22

it will be taken by the spleen
prematurely → if they stay in the
spleen with no glucose → They will
be hemolysed and anemia occurs

Question 23

what are the Clinical course Hereditary Spherocytosisof

Answer 23

1- Hemolytic crisis

2- Aplastic crisis

Question 24

Aplastic crisis affecting only … but .. an d… remains unbothered

Answer 24

• RBCs

- WBCs and platelets

Question 25

G6PDdeficiency is an ….disease

Answer 25

X-linked recessive

Question 26

the diseaese in whichHelmet cells ( Bite cells)

Answer 26

Patient with G6PD def → Oxidative Memrane damage