Clin Med Final Flashcards
(247 cards)
What is defined as the concentration of Hb in whole blood?
Hemoglobin
What is defined as the volume of packed RBCs?
Hematocrit
What is a calculated value used to determine the average size/volume of RBCs
Mean corpuscular volume MCV
What is the average Hb concentration in a RBC?
Mean corpuscular Hb concentration MCHC
What measures the degree of variation in RBC size?
Red cell distribution width RDW
What is anisocytosis?
Variation in size of RBCs
What is poikilocytosis?
Variation in shape of RBCs
What are the three types of microcytic hypochromic anemias?
Iron deficiency
Thalassemia
Sideroblastic
What is the one normocytic normochromic anemia?
Anemia of chronic disease
What are the two macrocytic megaloblastic anemias?
Folate deficiency
Vitamin B12 deficiency
What are common signs of all anemias?
Pallor
Heme in stool
Orthostatic changes
Tachycardia
What are common symptoms of all anemias?
Fatigue Weakness Headache Dizziness Dyspnea Palpitations
What is the most common cause of anemia? What population is it most prevalent in?
Iron deficiency anemia
Women of childbearing age
What are the causes of iron deficiency anemia?
Blood loss*
Decreased dietary intake
Decreased iron absorption
Labs show ↓ RBC ↓ Ferritin ↓ Serum Fe ↑ TIBC ↑ RDW
Smear shows
Microcytic, hypochromic RBCs
Anisocytosis
Poikilocytosis
What do you suspect?
Iron deficiency anemia
Clinical presentations include:
Atrophic glossitis Angular cheilitis Koilonychia Pica Dysphagia Restless leg syndrome
What do you suspect?
Iron deficiency anemia
What is the treatment for iron deficiency anemia?
Treat underlying cause*
Replace iron stores
Oral Ferrous Sulfate 325mg TID
Should see an increase of Hb at a rate of 2-4g/dL every 3 weeks until return to baseline
Continue for 3-6 months
What type of anemia is an inherited hemoglobinopathy that results in a reduction in synthesis of globin chains?
Thalassemia
What type of anemia leads to bone changes, impaired growth, and iron overload?
Thalassemia
Labs show ↑ RBC RDW is normal ↑ Ferritin ↑ Serum Iron ↓ TIBC
Smear shows
Microcytic, hypochromic RBCs
Target cells
What do you suspect?
Thalassemia
What can be used to help diagnose Thalassemia and can detect the type of Hb present?
Hemoglobin electrophoresis
A deletion of 1 of the 4 alpha globin chains results in what?
Silent carrier of Thalassemia
A deletion of 2 of the 4 alpha globin chains results in what?
a-thalassemia minor or mild microcytic anemia
A deletion of 3 of the 4 alpha globin chains results in what?
Hemoglobin H disease or moderate microcytic anemia