Clinical Coag Final

Question 1

What causes a prolonged bleeding time due to its effect on platelet aggregation?

Answer 1

aspirin

Question 2

What depends on the conversion of plasminogen in the plasma to the active form plasmin?

Answer 2

fibrinolysis

Question 3

What is a test for fibrinolysis?

Answer 3

clot lysis

Question 4

What is a more rapid test to detect increased clot lysis?

Answer 4

euglobin lysis time

Question 5

What is Stage I of coagulation?

Answer 5

the formation of plasma thromboplastin

Question 6

What is Stage II of coagulation?

Answer 6

conversion of prothrombin to thrombin

Question 7

What is Stage III of coagulation?

Answer 7

conversion of fibrinogen to fibrin

Question 8

What is thrombasthenia?

Answer 8

normal number and abnormal function of platelets

Question 9

What is thrombocytopenia?

Answer 9

decreased and normal function of platelets

Question 10

What is thrombocythemia?

Answer 10

increased and abnormal function of platelets

Question 11

What is telangiectasia?

Answer 11

hereditary vascular abnormality

Question 12

What is thrombocytosis?

Answer 12

increased and normal function of platelets

Question 13

What is the only factory deficiency that causes a prolonged thrombin time?

Answer 13

Fibrinogen (Factor I)

Question 14

What factors cause an increased PT?

Answer 14

VII, X, V, II, I

Question 15

What factors cause an increased PTT?

Answer 15

XII, XI, IX, VIII

Question 16

What factors cause an increased PT and PTT?

Answer 16

X, V, II, I

Question 17

Factor deficiencies involving labile factors must be treated with what?

Answer 17

fresh blood or FFP

Question 18

What are the labile factors?

Answer 18

V and VIII

Question 19

How is Hemophilia A and vonWillebrand’s disease distinguished?

Answer 19

bleeding time

Question 20

What factor deficiency is seen in both Hemophilia A and vonWillebrand’s disease?

Answer 20

Factor VIII

Question 21

What will correct a PT due to Factor VII deficiency?

Answer 21

Russell’s viper venom (Stypven)

Question 22

What is the initial plug in the wall of a vessel composed of?

Answer 22

platelets

Question 23

What replaces platelets in the plug in the wall of a vessel?

Answer 23

fibrin

Question 24

What Factor is required for the intrinsic system of coagulation?

Answer 24

Platelet Factor 3

Question 25

What is the normal platelet count?

Answer 25

150000-400000

Question 26

Bleeding does not usually occur unless the platelet count falls below what?

Answer 26

50,000

Question 27

What form of bleeding occurs most often when the platelet count falls below 50,000?

Answer 27

petechiae and ecchymoses

Question 28

What is the preferred anticoagulant for the PT and PTT?

Answer 28

sodium citrate

Question 29

What is the ratio of blood to anticoagulant in a sodium citrate tube required for a PT and PTT?

Answer 29

9 to 1

Question 30

What are the liver factors?

Answer 30

I, II, V, VII, IX, XIII

Question 31

What are the Vitamin K dependent factors?

Answer 31

II, VII, IX, X

Question 32

What are the adsorbed plasma factors?

Answer 32

V, VIII, XI, XII

Question 33

What are the aged serum factors?

Answer 33

VII, IX, X, XI, XII

Question 34

What is used to monitor the intrinsic pathway and heparin therapy?

Answer 34

PTT

Question 35

Normal values for the Duke method for bleeding time

Answer 35

1-3 minutes

Question 36

Normal values for the Ivy method for bleeding time

Answer 36

1-6 minutes

Question 37

Normal value for the template method for bleeding time

Answer 37

2.3-9.5 minutes

Question 38

What is the more rapid test to detect increased clot lysis?

Answer 38

euglobulin lysis time

Question 39

How much time is required to perform the euglobulin lysis time?

Answer 39

2 hours

Question 40

In interpreting fibrin split products, agglutination in neither the 1:5 or the 1:20 indicates

Question 41

In interpreting fibrin split products, agglutination in 1:5 but not in 1:20 indicates

Answer 41

>10 mcg/mL

Question 42

In interpreting fibrin split products, agglutination in 1:5 and 1:20 indicates

Answer 42

>40 mcg/mL

Question 43

What is the best test to distinguish between primary and secondary fibrinolysis?

Answer 43

platelet count, greatly decreased in secondary

Question 44

What is Stave IV of coagulation?

Answer 44

fibrinolysis

Question 45

What are the best tests to screen for coagulation disorders?

Answer 45

PT and PTT

Question 46

PT is used to monitor what?

Answer 46

Intrinsic pathway and heparin

Question 47

PTT is used to monitor what?

Answer 47

extrinsic pathway and coumadin

Question 48

What tests, other than PT, can be used to monitor heparin?

Answer 48

Lee White clotting time and Thrombin Time

Question 49

What is the only test for Factor XIII?

Answer 49

5M urea solubility test

Question 50

What initiates the extrinsic system of coagulation?

Answer 50

tissue factor III

Question 51

What initiates the intrinsic system of coagulation?

Answer 51

exposed collagen, activation of contact factor, or by platelet factor 3

Question 52

What factor is the contact factor?

Answer 52

Factor XII

Question 53

How does coumadin act?

Answer 53

Interferes with the synthesis of the Vitamin K dependent factors

Question 54

How does heparin act?

Answer 54

works with antithrombin III to neutralize thrombin

Question 55

What is the antidote for heparin?

Answer 55

protamine sulfate

Question 56

What is the principle of the fibrometer?

Answer 56

completes and electrical circuit between the two electrodes by the formation of a clot

Question 57

What is the principle of the coagulyzer, Coag-A-mate, and MLA?

Answer 57

detection of optical density changes in a cute by the photocell when the clot is formed

Question 58

What clotting factors have an enzymatically active form

Answer 58

II, VII, IX, X, XI, XII, and XIII

Question 59

What is the use of substitution testing with adsorbed plasma and aged serum?

Answer 59

pinpoints factor deficiencies

Question 60

How should the overall competence of the coagulation system be tested?

Answer 60

PT, PTT, bleeding time, clot solubility test, and a fibrinogen level