Clinical Enzymology/fxn If Covered Flashcards Preview

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Flashcards in Clinical Enzymology/fxn If Covered Deck (14):
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MI markers

Ck-MB and total CK (CK-MB >3-5% depending on other test). Early marker

cTnI and cTnT (not TnC) early marker. Lasts several days

LDH- late marker LDH1>LDH2 (switch)

Myoglobin (unspecific early marker)

1

Creatine kinase

Ck-MB (ck2)- MI marker. Early, peaks 24 hrs, gone after 48 hrs

Ck-MM (ck3)-rhapdomyolysis (I.e: mcardle gsd 5 myophosphorylase)

2

LDH

In MI LDH1>LDH2. Peaks @ 48, observable at 24 hrs. Half life 5 days.

Reversible: pyruvate to lactate, nad+ to nadh

3

Alanine amino transferase

ALT, marker for liver damage

EtOH abuse->cirrhosis AST/ALT >2

Alanine and a-Kg to pyruvate and glutamate

Use ala as substrate for gluconeogenesis.

4

Aspartate aminotransferase

Liver damage marker
AST
EtOH abuse->cirrhosis AST/ALT >2

5

Liver damage

AST, alt, ammonium, bilirubin, albumin

EtOH abuse->cirrhosis AST/ALT >2

6

Biliary system

Alkaline phosphotase (liver isozyme), GGT (gamma glutamyl transpeptidase)

7

Alkaline phosphotase

Biliary obstruction w/ GGT (ALP-1)

Bone (alone) (ALP-2)

8

Gamma-glutamyltranspeptidase (transferase)

Makes GSH

Biliary obstruction marker with ALP

Increased in response to EtOH or other medications

9

EtOH abuse

AST/ALT >2

High GGT

Lipase/Amylase >2

10

Pancreatitis

a-amylase, pancreatic lipase

Acute: gallstones, heavy ETOH intake (lipase/amylase>2)

Chronic: CF, hypertriglycerolemia, years of alcoholism.

11

Bones

ALP-2 (made by osteoblasts)

Bone disease or tumors

High levels normal in growing children and pregnancy.

12

Prostate cancer

PSA

13

a-fetoprotein (AFP)

Hepatocellular, testicular, ovarian tumors