Flashcards in Final Review Deck (51):
Specialized product of tryptophan
Serotonin, melatonin, nad, NADP
Specialized products of tyrosine, phenylalanine
Epinephrine. Norepinephrine. Melanin. Dopamine. Thyroid hormones.
Specialized product of Arginine
Nitric oxide, creatinine
Specialized products of histidine
Specialized product of glutamic acid
Specialized product of glycine
Heme and glutathione
Cofactors methylmalonyl coa mutase
Cofactors methionine synthase
Cofactor cytochrome c oxidase
Cofactors superoxide dismutase
Cofactor Lysyl oxidase
Cofactor dopamine beta hydroxylase
Copper, vit c
Low copper, x linked
High copper, deficient ceruloplasmin
Causes microcytic anemia
Low copper, low PLP, low iron,
Heme from meat. Ferric iron from green leafy veggies. Must be converted to ferrous iron in intestine (ceruloplasmin has feroxidase activity)
Where is iron stored?
Reticulocytes and liver
What form is iron stored in?
Symptoms of hereditary hemochromatosis
Accumulation of stored iron.
Bronze skin, diabetes, heart dysfunction, liver damage
Use of zinc
Result of zinc deficiency
Iodine used in....
Deficiency of iodine leads to....
What needs selenium?
What needs manganese?
What needs magnesium?
Enzymes using ATP
Beta hexamidase a GM2(ganglioside) onion inclusions.. cherry red spot macula densa Deadsies
Sphingomyelinase, sphingomyelin, foamy cell. Type A is fatal by 2-3y Type B causes HS megaly.
Alpha galatosidase , globosides, bathing trunk rash, peripheral neuropathy.
Beta glucosidase, glucosyl ceremide, HS megaly, osteoporosis, NO NEUROPATHY
Aryl sulfatase A, sulfatides, progressive paralysis and demyelination.
I cell disease
Inability to phosphorylate mannose, poor targeting, sphingomyelin and GAGs, Looks like hurlers.
Idonurate sulfatase, heparan/dermatan sulfate, NO Cataracts
L alpha idonurase, HS/ds, cataracts
Acid Maltase, glycogen, cardiomyopathy, liver and muscle damage
Made in liver, low causes edema
High in adults liver, testicular, or ovarian cancer
High in amnio, neural tube defect
Low in amnio, Down syndrome.
Alpha one antitrypsin
Inhibits neutrophil elastase marker for emphysema
Retinol binding protein
Alpha one , transports Retinol (vitamin a)
Alpha 2 macroglobulin
Huge and not normally secreted in urine, marker for glomerular damage (nephrosis)
Transports copper. Marker for Wilson's disease if low. Also has feroxidase activity in intestines
Binds hb in serum. Low haptoglobulin indicates hemolysis
Cholesterol transport to peripheral tissues and liver. Contains apo b100.
Saves heme iron!
Prevents it's excretion
Transports iron in blood