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Flashcards in Final Review Deck (51):
0

Specialized product of tryptophan

Serotonin, melatonin, nad, NADP

1

Specialized products of tyrosine, phenylalanine

Epinephrine. Norepinephrine. Melanin. Dopamine. Thyroid hormones.

2

Specialized product of Arginine

Nitric oxide, creatinine

3

Specialized products of histidine

Histamine

4

Specialized product of glutamic acid

GABA, glutathione

5

Specialized product of glycine

Heme and glutathione

6

Cofactors methylmalonyl coa mutase

B12

7

Cofactors transaminase

PLP

8

Cofactors hydroxylase

BH4

9

Cofactors methionine synthase

B12

10

Cofactor cytochrome c oxidase

Copper

11

Cofactors superoxide dismutase

Copper

12

Cofactor Lysyl oxidase

Copper

13

Cofactors tyrosinase

Copper

14

Cofactor dopamine beta hydroxylase

Copper, vit c

15

Cofactor ceruloplasmin

Copper

16

Cause menke's

Low copper, x linked

17

Cause Wilson's

High copper, deficient ceruloplasmin

18

Causes microcytic anemia

Low copper, low PLP, low iron,

19

Iron absorption

Heme from meat. Ferric iron from green leafy veggies. Must be converted to ferrous iron in intestine (ceruloplasmin has feroxidase activity)

20

Where is iron stored?

Reticulocytes and liver

21

What form is iron stored in?

Ferritin/hemodexerin

22

Symptoms of hereditary hemochromatosis

Accumulation of stored iron.

Bronze skin, diabetes, heart dysfunction, liver damage

23

Use of zinc

Oxidases

24

Result of zinc deficiency

Acrodermititis enteropathica

25

Iodine used in....

Thyroid hormone

26

Deficiency of iodine leads to....

Goiter

27

What needs selenium?

Glutathione peroxidase

28

What needs manganese?

Pyruvate Carboxylase!

29

What needs magnesium?

Enzymes using ATP

30

Tay Sachs

Beta hexamidase a GM2(ganglioside) onion inclusions.. cherry red spot macula densa Deadsies

31

Niemann pick

Sphingomyelinase, sphingomyelin, foamy cell. Type A is fatal by 2-3y Type B causes HS megaly.

32

Fabry

Alpha galatosidase , globosides, bathing trunk rash, peripheral neuropathy.

33

Gaucher

Beta glucosidase, glucosyl ceremide, HS megaly, osteoporosis, NO NEUROPATHY

34

Metachromatic leukodystrophy

Aryl sulfatase A, sulfatides, progressive paralysis and demyelination.

35

I cell disease

Inability to phosphorylate mannose, poor targeting, sphingomyelin and GAGs, Looks like hurlers.

36

Hunter's

Idonurate sulfatase, heparan/dermatan sulfate, NO Cataracts

37

Hurlers

L alpha idonurase, HS/ds, cataracts

38

Pompe disease

Acid Maltase, glycogen, cardiomyopathy, liver and muscle damage

39

Albumin

Made in liver, low causes edema

40

Alpha fetoprotein

Alpha one
High in adults liver, testicular, or ovarian cancer
High in amnio, neural tube defect
Low in amnio, Down syndrome.

41

Alpha one antitrypsin

Inhibits neutrophil elastase marker for emphysema

42

Transcortin

Alpha one
Transports cortisol

43

Retinol binding protein

Alpha one , transports Retinol (vitamin a)

44

Alpha 2 macroglobulin

Alpha two
Huge and not normally secreted in urine, marker for glomerular damage (nephrosis)

45

Ceruloplasmin

Alpha two
Transports copper. Marker for Wilson's disease if low. Also has feroxidase activity in intestines

46

haptoglobulin

Alpha two
Binds hb in serum. Low haptoglobulin indicates hemolysis

47

Beta LDL

Cholesterol transport to peripheral tissues and liver. Contains apo b100.

48

Hemopexin

Beta
Saves heme iron!
Prevents it's excretion

49

Transferrin

Transports iron in blood

50

Immunoglobulins

Gamma
One elevated in multiple myeloma
All in liver cirrhosis