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Robbins Pathology GI (Chptr 16,17,18,19) > Clinical- IBD > Flashcards

Clinical- IBD Flashcards

(53 cards)

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1
Q

Overall, what is the result of irritable bowel disease

A

Increased permeability of the epithelium of the gut

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2
Q

What is the immunogenetics component to IBD

A

HLA-DR2

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3
Q

What is the gene association with IBD

A

CARD15/NOD2

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4
Q

Which antibody is commonly associated with Ulcerative colitis

A

ANCA (antineutrophil cytoplasmic antibodies)

*Notice the relation to PSC

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5
Q

What antibody is commonly associated with Crohn disease

A

ASCA (anti Saccharomyces cerevisiae)

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6
Q

What are the main therapies for IBD

A

-5-aminosalicylic acid, corticosteroids, immunomodulating agents

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7
Q

What are the common other conditions seen with IBD

A

Peripheral arthritis
Erythema nodosum, pyoderma gangrenosum (especially with UC)
Thrombolytic effects (DVT)
Renal stones with urate or calcium oxalate (especially with crohns)

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8
Q

Which IBD condition has non-caseating granulomas

A

Crohns

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9
Q

What condition is characterized by the “cobblestone”appearance

A

Crohns

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10
Q

Which condition commonly has “creeping fat”

A

Crohns

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11
Q

What other condition commonly has non caseating granulomas

A

Sarcoidosis

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12
Q

Which of the IBD commonly has pseudopolyps

A

UC

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13
Q

Which IBD commonly has granulomas

A

Crohn disease

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14
Q

Which of the IBD will commonly have bloody diarrhea

A

UC

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15
Q

Which IBD is commonly seen to have fulminant colitis

A

UC

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16
Q

What is fulminant colitis

A

Severe disease characterized by rapidly worsening symptoms with signs of toxicity

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17
Q

Which IBD is commonly seen to have defects on growth

A

Crohns

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18
Q

Which IBD is commonly seen to have acute ileitis mimicking appendicitis

A

Crohns

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19
Q

Which IBD is commonly seen to have anorectal fissures, fistula, abscesses

A

Crohns

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20
Q

Which IBD is commonly seen to have toxic megacolon

A

UC

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21
Q

Which IBD is commonly seen to have intestinal obstruction

A

Crohns

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22
Q

Which IBD is commonly seen to have a reduced risk after having a appendectomy before age 20

23
Q

Which IBD commonly presents following cessation of smoking

24
Q

What is the key to diagnosis for UC

Study These Flashcards
A

Sigmoidoscopy

25
What is the key to diagnosis in Crohns
Sigmoidoscopy, curium edema, Upper GI and small bowel series
26
UC is commonly seen to have what lab findings
Increased sedimentation rate/CRP Increased fecal calprotectin levels Anemia
27
Crohns is commonly found to hav which lab findings
Hypoalbuminemia | Anemia
28
Which IBD is commonly seen to have edema, friability, mucous, and erosions
UC
29
Which IBD is commonly seen to have lead pipe on barium swallows
UC
30
Which diagnostic test should not be run on UC and what is the reasoning
Colonoscopy due to the risk of perforation
31
What is te diagnostic test order for Crohns
Colonoscopy and a biopsy
32
What are the biopsy findings in Crohn’s disease
Skip lesions with stellate ulcers, stricture, and segmental involvement of healthy tissue followed by unhealthy
33
Granulomas on biopsy is indicative of which IBD
Crohns
34
In the complication of Crohns with an abcess, what is the process
- Usualy presents with a fever and leukocytosis - Emergent CT - Broadspectum antibiotics - Percutaneous drainage or surgery
35
What is the indication or finding in an intestinal obstruction in crohns
Intravenous fluids with nasogastric suction
36
What is the diet given for patients with obstructive due to crohns
-Low roughage diet (aka no raw fruits, veggies, popcorn, nuts)
37
What is the presentation of retroperitonieal phlegmon or abcess
Fevers, chills, tender ab mass, leukocytosis
38
What is the fistula between the small intestine and colon called
Enterocolonic
39
What is the presention of a entercolonic fistula
Usually asymptomatic, but can have diarrhea, weight loss, bacterial overgrowth
40
What is the names of the fistulas that form with the bladder
Colovesical (colon to bladder) | Enterovesical (Small intestine to bladder)
41
What is the symptom associated with fistulas connecting to the bladder
Recurrent urinary infection
42
What is the symptom of a fistula with the vagina
Malodorous drainage and problems with hygiene
43
What is the cause of cutaneous fistulas
Surgical scars
44
Which IBD is commonly seen to have perianal disease
Crohn
45
What is perianal disease characterized by
Skin tags, anal fissures, perianal abscesses, fistulas
46
What is the best way to treat perianal disease
With a colorectal surgeon and using an MRI
47
Which IBD is commonly seen to have severe hemorrhage
Crohns
48
When there is the resection of the terminal ileum, what can occur
Reduced resorption of the bile acids, leading to secretory diarrhea
49
Patients with extensive ideal disease should not be given which compounds and what are commonly associated with it
Should not be given bile salt binding agents, as it can cause diarrhea, as well as kidney stones
50
What are the side effects of administering glucocorticoids for IBD
-mood changes, insomnia, buffalo hump, weight gain (striae), moon faces
51
What are the side effects of 5-ASA
Aka aspirin | -Acute interstial nephritis
52
What should always be administered with AZO components
-Folate
53
What should always be tested for before administration of azathioprine or 6-MP
-TPMT or thiopurine methyltransferase

Robbins Pathology GI (Chptr 16,17,18,19) (32 decks)

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