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Flashcards in CLINICAL MICRO Deck (238)
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1

What is a representative member of non-enterococcal group D strep?

S. bovis (subacute endocarditis is perforated colon cancer)

1

Compare the rash of tick-borne rickettsia to that of louse-borne rickettsia

Tick = RMSF = palms and soles to trunk (centripetal); Louse = epidemic typus (R. prowazekii) = trunk to palms and soles (centrifugal)

2

What are the Sx of Mycobacterium kanasii?

pulmonary TB like Sx

2

What disease has morulae in granulocyte cytoplasm)

Anaplasmosis (monocyte would be Ehrlichia)

3

When growing bugs on EMB agar, what do lactose fermenters look like? What does E. coli look like?

Lactose fermenters = purple, E. coli = purple with metallic green sheen

3

Why is there no vaccine for N. gonnorrhoaea?

Antigenic variation of the pili

3

What is the natural reservoir of Borrelia burgdorferi?

mouse

4

Which type of streptococcal infection (anatomically) is most likely to caus glomerulonephritis?

Skin infections (impetigo) but pharyngitis can still cause it

4

Name 4 species of Clostridium and their respective toxins

C. difficile (Toxin A = enterotoxin/diarrhea. Toxin B = cytoskeletal damage and pseudomembranous colitis), C. tetani (tetanospasmin), C. botulinum (botulinum toxin), C. perfringens (alpha toxin = phospholipase C)

4

What bug can you get from cattle and sheep amniotic fluid?

Coxiella burnettii (Q fever); veteranarians

5

Which form of Hansen's disease is characterized by a Th2 response?

Lepromatous; recall that Th2 is humoral. Since the severity of leprosy depends on CMI, the presence of a humoral response implies a poor CMI which is why it is lepromatous rather than tuberculoid

5

What stabilizes the membrane of Mycoplasma pneumoniae?

sterols (no cell wall)

6

Between which 2 bugs does an optochin test differentiate?

Viridans strep (R ) and S. pneumoniae (S)

6

What is the Jarisch-Herxheimer reaction?

A flu-like syndrome after initiation of penicillin G for syphilis; due to a release of pyrogens from the lysed bacteria

6

What causes neonatal staccato cough?

Pneumonia caused by C. trachomatis D-K serotypes

7

Which type of E. coli ferments sorbitol?

Everything but EHEC

8

What is the triad of Hemolytic Uremic Syndrome? Most common serotype of E. coli to cause? What other bug can cause?

anemia, thrombocytopenia, and acute renal failure; O157:H7; Shigella spp.

8

What is the vector for Rickettsia prowazekii?

louse

9

What is Elek's test?

The test for diphtheria toxin

10

How would you treat lumpy jaw?

Ampicillin is the DOC for Actinomyces israelli

10

What serotypes of C. trachomatis cause lymphogranuloma venereum?

L1, L2 , and L3

11

What bug can be diagnosed by gram positive rods with metachromatic (blue and red) granules?

Corynebacterium diphtheriae

11

Name 6 spore formers (Hint: 3 are from the same genus)

B. anthracis, C. perfringens, C. tetani, C. botulinum, B. cereus, Coxiella burnetii (Q fever)

11

What is the most invasive type of Haemophilus influenzae?

Type B

11

How do you treat C. trachomatis?

Azithromycin (or doxy) with Ceftriaxone for likely Gonorrheal co-infection

12

What are the 3 main genera of spirochetes?

Leptospira, Treponema, and Borrelia

12

Name 3 diseases that have a palm and sole rash

Rickettsia rickettsii (RMSF), Coxsackie A16 (hand foot and mouth), Secondary syphilis

14

Which species of Strep is hippurate positive?

S. agalactiae

14

Chronic pneumonia in CF patients is usually caused by _________ and the most important virulence factor here is __________

P. aeruginosa; Biofilm

15

What is the U.S. reservoir for leprosy?

Armadillo foot pads